1,723,876 research outputs found
Fraser, L H S, 5103
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/386182Surname: FRASER. Given Name(s) or Initials: L H S. Military Service Number or Last Known Location: 5103. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 45386.254246
Item: [2016.0049.18475] "Fraser, L H S, 5103
Block Card 5103 Avonhurst Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | 5103 Avonhurst Road (Toledo, Ohio) | Dwelling | Grandview Woods Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Chicago, Rock Island & Pacific (RI) 5103
No full textA photograph print showing the Chicago, Rock Island & Pacific (CRIP, RI, or ROCK) 5103, 4-8-4, on a passenger train at the station, Topeka, KS. [see also 2008.008.6762
Abstract 5103: The dark cancer kinome - untapped opportunities for the development of novel drugs
No full textAbstract Kinases are firmly established drug targets in cancer. There are currently 44 FDA approved kinase drug and hundreds of compounds are in clinical development. However, less than 10% of the Kinome is currently targeted and a large proportion is considered understudied by the NIH Illuminating the Druggable Genome Program (https://druggablegenome.net/). No small molecule inhibitors are known for these “dark” proteins, yet many may be opportune novel cancer targets.We developed a computational pipeline to identify and prioritize understudied kinases as cancer drug targets. We analyzed the complete set of tumors in The Cancer Genome Atlas (TCGA). For 33 different cancers we performed differential expression analysis and identified 39 dark kinases that exhibit significant upregulation in at least four types. Using co-expression analysis we built functional networks prioritizing drug targets. To identify small molecules that reverse their expression levels, we leveraged transcriptional response signatures obtained from dozens of human cancer cell lines exposed to tens of thousands of small molecules from the Library of Integrated Network-based Cellular Signatures (LINCS). To identify small molecules that directly bind to and inhibit dark kinases, we have have combined an advanced AI (artificial intelligence) model trained on activity data from across the Kinome with structure-based simulations.Using the computational pipeline, we identified the dark Ca2+/Calmodulin dependent kinase PNCK as the most differentially overexpressed kinase in kidney cancer patients. Our analyses have demonstrated statistically significant correlation between PNCK mRNA levels and various clinical and pathological outcomes, including histologic grade, clinical staging and overall survival. We have confirmed high levels of PNCK expression in 5 renal cell carcinoma cell lines (Caki-1, ACHN, 786-O, A704 and A498). Knockdown and overexpression studies have suggested PNCK and the CaMK pathway may contribute to cellular proliferation and cell cycle progression. We have applied our AI-based screening pipeline to a library of >20 million commercially available compounds and confirmed three PNCK inhibiting chemotypes. In summary, using a novel computational pipeline, we have identified and experimentally validated PNCK as a prospective novel drug target in an understudied pathway that is highly upregulated in kidney cancer. We identified first in class small molecules that target this previously dark kinase as prospective starting points for optimization into a clinical candidate. Citation Format: Derek J. Essegian, Rimpi Khurana, Vasileios Stathias, Valery Chavez, Jaime R. Merchan, Stephan Schürer. The dark cancer kinome - untapped opportunities for the development of novel drugs [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5103
Block Card 5103 Ford Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 5103 Ford Avenue (Toledo, Ohio) | Dwelling | Lawrence Place Addition (Toledo, Ohio) | Greenwood Park area (Toledo, Ohio) | West Toledo area (Toledo, Ohio) | Ranch house
An intranuclear microsporidian in lumpfish Cyclopterus lumpus
No full textChronic mortalities in lumpfish Cyclopterus lumpus reared in a saltwater recirculation system were associated with the presence of an intranuclear microsporidian. Morphological changes were characterized by infiltration of lymphocyte-like cells predominantly in the renal interstitium and also in the spleen, liver, gills, stomach, pyloric caecae, heart, ovary and mesenteric fat. Affected cell nuclei contained 1 to more than 6 spherical to oval eosinophilic bodies which stained poorly with haematoxylin and eosin and Giemsa. Ultrastructurally, spores were ovoid (2.1 x 1.0 micro m) with a polar tube with 11 turns. The morphology of the spores place them in the genus Enterocytozoon. These spores resemble E. salmonis in salmonids, and Microsporidia rhabdophilia in the rodlet cells of salmonids..RE: 12 ref.; SC: ZA; CA; HE; VE; PA; 0YSource type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0177-5103&isbn=&volume=20&issue=1&spage=7&pages=7-13&date=1994&title=Diseases%20of%20Aquatic%20Organisms&atitle=An%20intranuclear%20microsporidian%20in%20lumpfish%20Cyclopterus%20lumpus.&aulast=Mullins&pid=%3Cauthor%3EMullins%2c%20J%20E%3bPowell%2c%20M%3bSpeare%2c%20D%20J%3bCawthorn%2c%20R%3C%2Fauthor%3E%3CAN%3E19950804101%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Experimental transmission of Marteilia refringens with special consideration of its life cycle
No full textThe life history of Marteilia refringens was investigated. The infectivity of purified early and late stages of M. refringens to oysters (Ostrea edulis) was tested in the laboratory using different routes of inoculation. Naturally infected oysters were monitored in experimental tanks to study infection progression through serial samples. Horizontal transmission was tested by cohabitation with carrier oysters in experimental tanks. The role of the environment in the transmission of M. refringens was studied in the field. The experiments provided no evidence to support direct horizontal transmission of M. refringens, but suggested that intermediate or alternative hosts, or free-living stages, are essential in the life cycle of the parasite..RE: 46 ref.; SC: ZA; VE; CA; PA; 0YSource type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0177-5103&isbn=&volume=34&issue=2&spage=135&pages=135-144&date=1998&title=Diseases%20of%20Aquatic%20Organisms&atitle=Experimental%20transmission%20of%20Marteilia%20refringens%20with%20special%20consideration%20of%20its%20life%20cycle.&aulast=Berthe&pid=%3Cauthor%3EBerthe%2c%20F%20C%20J%3bPernas%2c%20M%3bZerabib%2c%20M%3bHaffner%2c%20P%3bThebault%2c%20A%3bFigueras%2c%20A%20J%3C%2Fauthor%3E%3CAN%3E19990802291%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Comparative analysis of a monoclonal-antibody-based immunofluorescence test for plasmacytoid leukemia in chinook salmon Oncorhynchus tshawytscha
No full textPlasmacytoid leukaemia (PL) is a lymphoproliferative disorder that affects netpen-reared chinook salmon in British Columbia, Canada. The only diagnostic test for PL is histological evaluation of suspect fish. Monoclonal antibodies (MAbs) previously reported to react with tissues of PL-affected fish were used in a quantitative indirect fluorescence antibody (IFA) test. These MAbs reacted with a 75 kDa antigen that is highly expressed in tissues of fish with PL. Using experimentally infected fish, the sensitivity, specificity, and predictive values of the IFA test were compared with those of the standard histological test. The IFA test was found to have a sensitivity of 72%, which was significantly higher than that of histological examination, and could detect experimental infection at 3 wk after injection, earlier than histological examination. The sensitivity and practicality of the IFA test will enable it to be a useful screening test for the detection of PL..RE: 19 ref.; SC: CA; VE; ZA; BE; 0I; 0VSource type: Electronic(1) http://upei-resolver.asin-risa.ca?sid=SP:CABI&id=pmid:&id=&issn=0177-5103&isbn=&volume=21&issue=2&spage=123&pages=123-130&date=1995&title=Diseases%20of%20Aquatic%20Organisms&atitle=Comparative%20analysis%20of%20a%20monoclonal-antibody-based%20immunofluorescence%20test%20for%20plasmacytoid%20leukemia%20in%20chinook%20salmon%20Oncorhynchus%20tshawytscha.&aulast=Newbound&pid=%3Cauthor%3ENewbound%2c%20G%20C%3bMarkham%2c%20R%20J%20F%3bKent%2c%20M%20L%3bSpeare%2c%20D%20J%3bThorburn%2c%20M%20A%3C%2Fauthor%3E%3CAN%3E19952211543%3C%2FAN%3E%3CDT%3EJournal%20article%3C%2FDT%3
Block Card 5103 Valley Forge Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 5103 Valley Forge Drive (Toledo, Ohio) | Cape Cod Style | Colonial Village | Greenwood Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
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