1,774,254 research outputs found
Participant 503 Community Conversations Sculpture
No full textThis sculpture submission by Participant 503 is a tower made from toilet paper rolls. The participant says this tower represents strength, resiliency, and hope. It also symbolizes how scarce basic necessities were during the pandemic.New Jersey Department of Healt
Resolución UNRN N° 503/2009. Otorga equivalencia
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN N° 503/2009. Otorga equivalenciafals
Bone-Targeting HUVEC-Derived Exosomes Containing miR-503-5p for Osteoporosis Therapy
No full textOsteoporosis
(OP) is a systemic bone disease characterized by decreased
bone mass, damaged bone microstructure, increased bone fragility,
and increased risk of fractures. It is more common in postmenopausal
women and elderly people. The development of drugs with a high bone-targeting
ability is urgently needed. We prepared a bioactive nanoparticle that
modified the exosomes derived from human umbilical vein endothelial
cells (HUVEC-ExomiR‑503‑high) to contain
a large amount of miR-503-5p, with a diameter range of 30–150
nm. The HUVEC-ExomiR‑503‑high that we constructed
had the same characteristics as ordinary exosomes and could bind to
osteoblasts/osteoclasts in vitro. Moreover, they exhibited better
bone-targeting ability than exosomes derived from other sources of
bone marrow stromal cells in vivo. Bioinformatics analysis showed
that miR-503-5p is strongly associated with bone-related pathways.
In vitro experiments showed that HUVEC-ExomiR‑503‑high effectively inhibited osteoclast differentiation and promoted osteogenic
differentiation. In vivo experiments showed that injecting HUVEC-ExomiR‑503‑high into OP mice significantly increased
bone density and prevented OP. HUVEC-ExomiR‑503‑high can be used for bone-targeted therapy of OP, providing an approach
to the clinical prevention and treatment of OP
Mineralogy at DSDP Sites 68-502 and 68-503
No full textEighty-four sediment samples from four holes at Site 502 and 54 samples from three holes at Site 503 were analyzed for mineral content by semiquantitative X-ray diffraction methods.
Site 502 is located in the Western Caribbean, whereas Site 503 lies in the Eastern Pacific (probably on the north flank of the Galapagos Spreading Center). Both sites were chosen to yield continuous core sections for investigations of late Neogene and Quaternary biostratigraphy and magnetostratigraphy and to study events such as the closing of the Isthmus of Panama.
Our X-ray diffraction work should provide a framework for further investigations - for example, determination of climatic changes in relationship to clay mineral composition or the influx of terrigeneous sediment components from South America before and after development of the Panama landbridge
Public law 503
No full textThe text of Public Law 503 issued by Congress to enforce and Executive Order made by the President in 1942. The law states the penalty for anyone who interfered with military areas or procedures, which includes a fine up to $5,000, a prison sentence of a year, or both. The Executive Order and Public Law were enacted to give authority to the military for the evacuation and removal of Japanese Americans.The War Relocation Authority (WRA), together with the Wartime Civil Control Administration (WCCA), the Civil Affairs Division (CAD) and the Office of the Commanding General (OFG) of the Western Defense Command (WDC) operated together to segregate and house some 110,000 men women and children from 1942 to 1945. The collection contains documents and photographs relating to the establishment and administrative workings of the (WDC), the (WRA) and the (WCCA) for the year 1942
(Table 1) Magnetozone boundaries at DSDP Site 68-503
No full textThe paleomagnetic measurement procedure at Site 503 was similar to that described for Site 502 (See preceding chapter). Each core section was measured with the longcore spinner magnetometer at 10-cm intervals. In addition, one or more discrete samples were taken from each core section for measurement of the total magnetic vector and its stability against progressive AF demagnetization. There were noteworthy differences in conditions at Site 503, however, that affected the quality and interpretation of the magnetic data and require comment.
The most serious problem we encountered was the presence of rust scale from the drill string. Although the dark flecks typically were concentrated near the top of every recovered sediment core, they also smeared down a meter or more between the core liner and sediment, even when the sediment showed no indication of drilling disturbance. Individual rust scales proved to be highly magnetic - presumably because they incorporate small pieces of unoxidized metal. The anomalously high remanent intensities, several orders of magnitude above the uncontaminated sediment values, and scattered remanent directions observed in long-core magnetic measurements on many cores from Site 503 could be attributed to the presence of rust scale
<b>Beta-cell </b><b><i>MiRNA-503-5p</i></b><b> Induced by Hypomethylation and Inflammation Promotes Insulin Resistance and β-Cell Decompensation</b>
No full textABSTRACTChronic inflammation promotes pancreatic β-cell decompensation to insulin resistance due to local accumulation of supraphysiologic IL-1β levels. However, the underlying molecular mechanism(s) remains elusive. We show that miR-503-5p is exclusively upregulated in islets from type 2 diabetic humans and rodents due to its promoter hypomethylation and increased local IL-1β levels. Beta-cell-specific miR-503 transgenic (βTG) mice display mild or severe diabetes in a time- and expression-dependent manner. By contrast, deletion of the miR-503 cluster protects mice from high-fat-diet-induced insulin resistance and glucose intolerance. Mechanistically, miR-503-5p represses JNK interacting protein 2 (JIP2) translation to activate mitogen-activated protein kinases (MAPKs) signaling cascades, thus inhibiting glucose-stimulated insulin secretion (GSIS) and compensatory β-cell proliferation. In addition, β-cell miR-503-5p is packaged in nano-vesicles to dampen insulin signaling transduction in liver and adipose tissues by targeting insulin receptors (INSR). Notably, specifically blocking the miR-503 cluster in β cells effectively remits ageing-associated diabetes through recovery of GSIS capacity and insulin sensitivity. Our finding demonstrated that β-cell miR-503-5p is required for the development of insulin resistance and β-cell decompensation, providing a potential therapeutic target against diabetes.</p
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