1,723,847 research outputs found
Phase 1 study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers
No full textWe assessed the safety, tolerability and efficacy of the immunomodulatory drug, CC-5013 (REVIMID(TM)), in the treatment of patients with metastatic malignant melanoma and other advanced cancers. A total of 20 heavily pretreated patients received a dose-escalating regimen of oral CC-5013. Maximal tolerated dose, toxicity and clinical responses were evaluated and analysis of peripheral T-cell surface markers and serum for cytokines and proangiogenic factors were performed. CC-5013 was well tolerated. In all, 87% of adverse effects were classified as grade 1 or grade 2 according to Common Toxicity Criteria and there were no serious adverse events attributable to CC-5013 treatment. Six patients failed to complete the study, three because of disease progression, two withdrew consent and one was entered inappropriately and withdrawn from the study. The remaining 14 patients completed treatment without dose reduction, with one patient achieving partial remission. Evidence of T-cell activation was indicated by significantly increased serum levels of sIL-2 receptor, granulocyte- macrophage colony-stimulating factor, interleukin-12 (IL-12), tumour necrosis factor-alpha and IL-8 in nine patients from whom serum was available. However, levels of proangiogenic factors vascular endothelial growth factor and basic foetal growth factor were not consistently affected, This study demonstrates the safety, tolerability and suggests the clinical activity of CC-5013 in the treatment of refractory malignant melanoma. Furthermore, this is the first report demonstrating T-cell stimulatory activity of this class of compound in patients with advanced cancer
Santa Fe (ATSF) 5013
No full textA photograph postcard showing Santa Fe (ATSF) 5013, 2-10-4, westbound east of Amarillo, TX, 98 cars, 35 mp
Santa Fe (ATSF) 5013
No full textA photograph postcard showing the Santa Fe (ATSF) 5013, 2-10-4, westbound near Folsom, TX, 98 cars, 35 mph. Plains Divisio
Траєкторія науки = Traektoriâ Nauki = Path of Science. 2017. № 12. С. 5001–5013.
No full textГолованова А. Ю., Киричек Л. Т., Єрмоленко Т. І., Гладких Ф. В. Фармакотерапевтичний ефект стреспротекторів у віковому аспекті. Траєкторія науки = Traektoriâ Nauki = Path of Science. 2017. № 12. С. 5001–5013.В роботі наведено відомості про фармакотерапевтичні ефекти стреспротекторів у віковому аспекті
Block Card 5013 Prestler Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 5013 Prestler Road (Toledo, Ohio) | Dwelling | Westhaven First Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio
Block Card 5013 Brandon Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cross gabled | 5013 Brandon Road (Toledo, Ohio) | Dwelling | Westhaven First Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio) | Folk House Styl
[Southern Pacific 5013 Train, Negative]
No full textNegative of Southern Pacific Railway's 5013 train. The dark train sits behind another train visible on the right edge of the photograph. The cylindrical locomotive, covered in pipes and a bell, sits ahead of a square cab with a man leaned out of its window. A cylindrical train car with a square section sits behind the locomotive to the left. The railroad curves on the left of the photograph, parallel to trees and utility poles
[Southern Pacific 5013 Locomotive, Print]
No full textPhotograph of Southern Pacific Railway's 5013 train locomotive. The wide, circular locomotive is covered in horizontal pipes and short smokestacks. A square cab with an arched roof is sat at the back of the locomotive to the left, a person leaning out of its window. A rectangular train car is pulled by the locomotive on the left. The railroad curves to the right in the background, lined with power line poles
Linked collectors and determiners for: Institut Botanic de Barcelona (IBB, CSIC-Ajuntament de Barcelona), BC-Lichen-Navas.
No full textNatural history specimen data linked to collectors and determiners held within, "Institut Botanic de Barcelona (IBB, CSIC-Ajuntament de Barcelona), BC-Lichen-Navas". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/079a1c1f-5013-4348-b963-dcc2f4dadb9d">https://bionomia.net/dataset/079a1c1f-5013-4348-b963-dcc2f4dadb9d</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/079a1c1f-5013-4348-b963-dcc2f4dadb9d">https://gbif.org/dataset/079a1c1f-5013-4348-b963-dcc2f4dadb9d</a>. Formatted as a Frictionless Data package
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