1,724,374 research outputs found
Exercises for course 5011
No full textManual for computer exercises for course 5011, Linear Control Design 2
Pennsyvania (PRR) 5011
No full textA photograph print showing the Pennsylvania Railroad (PRR) 5011, 4-4-2, Altoona, PA
Santa Fe (ATSF) 5011
No full textA photograph postcard showing the Santa Fe (ATSF) 5011, 2-10-4, on freight train, no date or location
PMI 5011 regulates the ubiquitin proteasome system in skeletal muscle
Get PDFInsulin resistance in type 2 diabetes is associated with impaired glucose and protein metabolism in skeletal muscle. The impaired insulin signaling in skeletal muscle affects muscle mass by tilting the balance between skeletal muscle protein synthesis and degradation toward degradation, a process that is primarily regulated by the ubiquitin-proteasome system. Studies have shown that an extensively characterized ethanol extract of Artemisia dracunculus L (Russian Tarragon), termed PMI 5011, enhances insulin signaling in human primary skeletal muscle cells and in a rodent model of insulin resistance. The aim of this project is to determine if the effect of PMI 5011 on insulin signaling extends to regulation of ubiquitin-proteasome activity in skeletal muscle. To evaluate the effect of PMI 5011 on the ubiquitin-proteasome system, we used two in vitro models of insulin resistance in C2C12 myotubes and the KKAy mouse model of insulin resistance in vivo. Our studies show that PMI 5011 enhances the inhibitory effect of insulin on proteasome activity and ubiquitylation in skeletal muscle in vitro and in vivo. In addition, PMI 5011 inhibits non-proteasomal protein degradation in vivo, indicating that PMI 5011 is a potent inhibitor of skeletal muscle protein degradation. PMI 5011 also regulates the expression of Atrogin-1 and MuRF-1, muscle-specific ubiquitin ligases that are required for ubiquitin-dependent protein degradation in skeletal muscle. Both Atrogin-1 and MuRF-1 gene and protein expression is elevated with impaired insulin signaling and our studies show that PMI 5011 reduces the expression of these ligases while enhancing Akt phosphorylation. In summary, these studies demonstrate that PMI 5011 regulates the ubiquitin-proteasome in insulin resistant states in vitro and in vivo. PMI 5011 may therefore be a therapeutic target for enhancing insulin sensitivity leading to conservation of muscle mass in type 2 diabetes
Chicago, Burlington & Quincy (CBQ) 5011 (neg)
No full textA photograph negative showing Chicago, Burlington & Quincy (CBQ) 5011, 2-8-2, Kansas City, KS
Block Card 5011 Burlingame Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 5011 Burlingame Style (Toledo, Ohio) | Dwelling | Crestview Subdivision (Toledo, Ohio
Comparison of in vitro callus-cultures from transgenic maize AG-5011YG (MON810) and conventional near-isogenic maize AG-5011
No full textAbstract MON810 is a genetically-modified (GM) maize (Zea mays) event commonly employed in insect-resistant GM maize hybrids. GM events obtained by biolistic transformation methods, such as MON810, are generated by insertion of a recombinant gene expression cassette in a random locus of the plant genome, and this process may cause emergent properties besides the intended modification. Here, we compared morphophysiological parameters of MON810 GM maize hybrid AG-5011YG and its non-GM near-isogenic hybrid (NIH) AG-5011, using in vitro cultures as an interactive model. NIH callogenesis frequency, callus friability, and de novo morphogenesis were compared using two explant types and different 2,4-dichlorophenoxyacetic acid (2,4-D) levels. 2,4-D modulated the morphophysiological responses of both NIHs, but when using root segments as explants, the GM showed significantly different trends for callus induction and friability, with lower responses at higher 2,4-D concentrations, indicating an emergent property related to altered cell response to 2,4-D.</div
Block Card 5011 Geer Lane
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 5011 Geer Lane (Toledo, Ohio) | Dwelling | Westgate Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 5011 Wissman Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 5011 Wissman Drive (Toledo, Ohio) | Dwelling | Reynolds Place Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio
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