1,726,277 research outputs found
Hodgson, D H, 5002
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/392693Surname: HODGSON. Given Name(s) or Initials: D H. Military Service Number or Last Known Location: 5002. Missing, Wounded and Prisoner of War Enquiry Card Index Number: C12802.210505
Item: [2016.0049.24986] "Hodgson, D H, 5002
OLPD 5002 Private Colleges as Formal Organizations Syllabus
No full textSyllabus for OLPD 5002 Private Colleges as Formal Organizations - one of four courses that comprise the Private College Leadership Certificate program.Center for Innovative Higher Education. (2017). OLPD 5002 Private Colleges as Formal Organizations Syllabus. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/194754
Chicago, Rock Island & Pacific (RI) 5002
No full textA photograph print showing the Chicago, Rock Island & Pacific (CRIP, RI, or ROCK) 5002, 4-8-4, Kansas City, KS
OLPD 5002 Private Colleges as Formal Organizations Modules, Readings, Assignments
No full textModules, Readings, and Assignments for OLPD 5002 Private Colleges as Formal Organizations - one of four courses that comprise the Private College Leadership Certificate program.Center for Innovative Higher Education. (2017). OLPD 5002 Private Colleges as Formal Organizations Modules, Readings, Assignments. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/194755
Block Card 5002 Prestler Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: cabins | 5002 Prestler Road (Toledo, Ohio) | Dwelling | Westhaven First Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio
Block Card 5002 Kellogg Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Side gabled | 5002 Kellogg Road (Toledo, Ohio) | Dwelling | Westhaven First Addition (Toledo, Ohio) | Reynolds Corners Area (Toledo, Ohio) | Folk House Styl
Block Card 5002 Lewis Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: garages | 5002 Lewis Avenue (Toledo, Ohio) | Greenwood Area (Toledo, Ohio) | North Toledo Area (Toledo, Ohio) | Italiante Styl
INTEGRAL detection of X-ray transient source AX J1620.1-5002
No full textWe report the detection of the X-ray transient source AX J1620.1-5002, with the IBIS/ISGRI and JEM-X detectors aboard the INTEGRAL observatory, during the Galactic Plane Scan program (PI: Dr A. Bazzano). The source was observed during revolutions 1913 and 1914; observations were performed between 2018-01-29 15:06:58 and 2018-01-30 10:24:00 UTC (exposure time 326 ks). In a combined analysis of the two revolutions, we detect the source at RA = 245.03, Dec = -50.01, 3' error radius, and with an overall detection significance in the 22-60 keV band of 9 sigma. The flux was measured in the 22-60 keV as 1.2 +/- 0.2^-10 erg cm^-2 s^-1 (11.31 +/- 1.3 mCrab), with an effective exposure time of 23 ks. In revolution 1913 we measure the flux in the 22-60 keV energy band as 1.3 +/- 0.3^-10 erg cm^-2 s^-1 (12.31 +/- 2.9 mCrab), with an effective exposure time of 4 ks. In revolution 1914 we measure the flux in the 22-60 keV energy band as 1.0 +/- 0.2^-10 erg cm^-2 s^-1 (9.23 +/- 1.3 mCrab), with an effective exposure time of 18 ks. AX J1620.1-5002 was only in the JEM-X FOV during revolution 1914 and well detected at RA= 245.07, Dec=-50.02, 90% 2' error radius. Flux values are as following: 3-10 keV: 7 +/- 1 mCrab (1.1 +/- 0.2 ^-10 erg cm^-2 s^-1) at 7 sigma for 10 ks exposure and10-25 keV: 13 +/- 5 mCrab (1.3 +/- 0.5^-10 erg cm^-2 s^-1) at 3 sigma for 9.6 ks exposure. We believe this to be the first confirmed detection of AX J1620.1-5002 at hard X-ray energies. We note that in October 2017, MAXI observed a new source, MAXI J1621-501 (ATel #10869). Its measured position is offset by ~12' from AX J1620.1-5002 and the MAXI error circle is ~13'; i.e., consistent with the position of both AX J1620.1-5002 and our detection. The nature of AX J1620.1-5002 is still not known but is a suggested candidate magnetically accreting white dwarf (Degenaar et al. 2012 A&A, 540, 22), but an HMXB nature cannot be completely ruled out (Gemma et al. 2014, ApJSS, 212, 13)
The Zinc Ionophore PCI-5002 Radiosensitizes Non-small Cell Lung Cancer Cells by Enhancing Autophagic Cell Death
No full textIntroductionA major focus of cancer research is to identify compounds that sensitize resistant cancer cells to radiation treatment. Lung cancer cells, in particular, have high rates of radioresistance that lead to treatment failure. We have previously shown that the autophagy induced in the context of decreased apoptosis confers radiosensitivity to prostate and lung cancer cells. Zinc supplementation has antiapoptotic effects in cell culture. In addition, the accumulation of zinc in response to oxidative stress has been associated with increased autophagy in astrocyte and breast cancer cells.MethodsIn this study, we hypothesized that the zinc ionophore PCI-5002 radiosensitizes lung cancer cells by inducing autophagic cell death. To test this hypothesis, we used a combination of in vitro and in vivo approaches, including clonogenic assays to test for radiosensitivity, biochemical analyses of apoptosis and autophagy, and a xenograft mouse model of tumor growth.ResultsWe found that PCI-5002 reduced clonogenic survival in treated cells compared with untreated cells (0.03% versus 0.1% surviving fraction, p < 0.001). The increased radiosensitive fraction of PCI-5002-treated cells was accompanied by increased autophagy. PCI-5002 treatment also reduced caspase-3 cleavage. In an irradiated xenograft mouse model, the tumor growth of irradiated, PCI-5002-treated mice was slower than untreated, irradiated mice (25 days versus 22 days to reach a 1.0 cm3 tumor size).ConclusionsPCI-5002 treatment sensitizes lung cancer cells to radiation, both in vitro and in vivo. This data suggest that PCI-5002 could potentially treat radioresistant/locally advanced lung cancer by amplifying the effects of radiotherapy
- …
