1,771,068 research outputs found
No On 490 Campaign Newsletter, 1986
No full textA newsletter summarizing of the activities, supporters, and defeat of the No On 490 Campaign, Washington State Initiative 490, the anti-gay rights workplace discrimination initiative in 1986.If Initiative 490 had passed, potential employers would be required by law to delve into the private lives of potential employees in order to determine their sexual orientation and hire (or not hire) as they see fit.
Homosaurus subject terms and some Contextual Notes were added to this item during the LGBTQ+ Materials Redescription Project in 2023
Why you should not sign Initiative 490 petitions, 1986
No full textA flier prepared by the No on 490 Committee stating why people should not sign Washington State Initiative 490, the anti-gay rights workplace discrimination initiative in 1986.If Initiative 490 were to pass, potential employers would be required by law to delve into the private lives of potential employees in order to determine their sexual orientation and hire (or not hire) as they see fit.
Homosaurus subject terms and some Contextual Notes were added to this item during the LGBTQ+ Materials Redescription Project in 2023
Connecticut's PA 490 Program (2021)
No full text1 online resource (2 unnumbered pages)"Updates 2017-R-0160."Discusses Connecticut's Public Act 63-490, commonly referred to as "PA 490" or the "490 program, which allows four classifications of land--farm, forest, open space, and maritime heritage--to be assessed at their current use value, rather than their fair market valu
Participant 490 Community Conversations Interview
No full textIn this written interview, Participant 490 shares that the COVID-19 pandemic changed their life a lot. They state that there were many people in New Jersey who were left homeless because of the pandemic and they wish there was more information advertised about social services. The participant says that the situation has unified people in their community.New Jersey Department of Healt
Additional file 4 of LncRNA LINC00483 promotes gastric cancer development through regulating MAPK1 expression by sponging miR-490-3p
No full textAdditional file 4: Figure S4. LINC00483 sponges miR-490-3p to regulate apoptosis, migration and invasion in gastric cancer cells. (A) Cell apoptosis was detected in MKN-45 and MGC-803 cells transfected with miR-NC, miR-490-3p, miR-490-3p and pcDNA or LINC00483 by flow cytometry. (B and C) Cell migration and invasion were measured in MKN-45 and MGC-803 cells transfected with miR-NC, miR-490-3p, miR-490-3p and pcDNA or LINC00483 by transwell assay
Image_1_LncRNA HCG11 Facilitates Nasopharyngeal Carcinoma Progression Through Regulating miRNA-490-3p/MAP3K9 Axis.tif
No full textPurposeLong noncoding RNAs (LncRNAs) play complex but important roles in the progression of various tumors. This study aimed to elucidate the functional mechanisms of the HLA complex group 11 (HCG11) in nasopharyngeal carcinoma (NPC).Patients and MethodsHCG11 levels in NPC specimens were determined by fluorescence in situ hybridization (FISH) and qPCR. Proliferation, apoptosis, and metastasis of NPC cells were determined using CCK8, colony formation, annexin V-PI, and transwell assays. A murine tumor xenograft model was used to investigate the regulatory function of HCG11 in NPC in vivo, and immunohistochemical staining was used to determine the Ki-67 level in tumors. The target relationships between HCG11, microRNA miR-490-3p, and MAPK kinase kinase 9 (MAP3K9) were detected using bioinformatics, qPCR, western blotting, and luciferase reporter assays.ResultsHCG11 was highly expressed in NPC tissues and was positively associated with tumor stage, lymphatic metastasis, and poor prognosis. Functionally, HCG11 knockdown inhibited proliferation and migration and induced apoptosis of NPC cells. Mechanistically, miR-490-3p is a direct target of HCG11, oncogenic functions of HCG11 in NPC cell proliferation and migration can be partially reversed by the miR-490-3p inhibitor. HCG11 significantly increased mitogen-activated protein kinase MAPK kinase 9 (MAP3K9) levels by inhibiting miR-490-3p.ConclusionHCG11 facilitates NPC progression via MAP3K9 signaling by sponging miRNA-490-3p, which may contribute to new prognostic markers and promising therapeutic targets.</p
DataSheet_1_LncRNA HCG11 Facilitates Nasopharyngeal Carcinoma Progression Through Regulating miRNA-490-3p/MAP3K9 Axis.docx
No full textPurposeLong noncoding RNAs (LncRNAs) play complex but important roles in the progression of various tumors. This study aimed to elucidate the functional mechanisms of the HLA complex group 11 (HCG11) in nasopharyngeal carcinoma (NPC).Patients and MethodsHCG11 levels in NPC specimens were determined by fluorescence in situ hybridization (FISH) and qPCR. Proliferation, apoptosis, and metastasis of NPC cells were determined using CCK8, colony formation, annexin V-PI, and transwell assays. A murine tumor xenograft model was used to investigate the regulatory function of HCG11 in NPC in vivo, and immunohistochemical staining was used to determine the Ki-67 level in tumors. The target relationships between HCG11, microRNA miR-490-3p, and MAPK kinase kinase 9 (MAP3K9) were detected using bioinformatics, qPCR, western blotting, and luciferase reporter assays.ResultsHCG11 was highly expressed in NPC tissues and was positively associated with tumor stage, lymphatic metastasis, and poor prognosis. Functionally, HCG11 knockdown inhibited proliferation and migration and induced apoptosis of NPC cells. Mechanistically, miR-490-3p is a direct target of HCG11, oncogenic functions of HCG11 in NPC cell proliferation and migration can be partially reversed by the miR-490-3p inhibitor. HCG11 significantly increased mitogen-activated protein kinase MAPK kinase 9 (MAP3K9) levels by inhibiting miR-490-3p.ConclusionHCG11 facilitates NPC progression via MAP3K9 signaling by sponging miRNA-490-3p, which may contribute to new prognostic markers and promising therapeutic targets.</p
Additional file 3: of CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression
No full textFigure S2. The association between miR-490-3p expression and the prognosis in patients with HCC. (A1–4) Pearson’s correlation coefficient analysis of the correlation of PPM1F expression with miR-429/−200c-3p/−200b-3p/− 186-5p in HCC tissues. (B) ROC curve analysis of the cutoff value, sensitivity, specificity and AUC of miR-490-3p in HCC tissues in our cohort. (C) Kaplan-Meier analysis of the association of high or low miR-490-3p expression with the overall survival of HCC patients in late stage in our cohort. (D) ROC curve analysis of the cutoff value, sensitivity, specificity and AUC of miR-490-3p in HCC tissues in TCGA cohort. (PDF 2903 kb
The Knotty Question of the Jet of PKS B1421-490
No full textWe report the discovery of unusually strong optical and X-ray emission associated with a knot in the radio jet of PKS B1421-490. The knot is the brightest feature observed beyond the radio band, with knot/core flux ratios ∼300 and 3.7 at optical and X-ray frequencies, respectively. We interpret the extreme optical output of the knot as synchrotron emission. The nature of the X-ray emission is unclear. We consider a second synchrotron component, inverse Compton emission from a relativistic, decelerating jet, and the possibility that this feature is a chance superposition of an unusual BL Lac object. © 2005. The American Astronomical Society. All rights reserved
Additional file 1: of CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression
No full textTable S1. List of the primer sequences. Table S2. The association of PPM1F expression with clinicopathologic characteristics of HCC patients. Table S3. Cox regression analysis of PPM1F expression as survival predictor of HCC patients. Table S4. Identification of miRNAs targeting PPM1F gene by microRNA.org . Table S5. Identification of miRNAs targeting PPM1F gene by TargetScan_7.1. Table S6. The association of miR-490-3p expression with clinicopathologic characteristics of HCC patients. Table S7. Cox regression analysis of miR-490-3p expression as survival predictor of HCC. Table S8. Cox regression analysis of miR-490-3p expression as recurrence predictor of HCC. Table S9. Identification of the circRNAs than sponge the miR-490-3p. Table S10. List of Ago2 occupancy in the region of circSLC3A2. Table S11. The association of circSLC3A2 expression with clinicopathologic characteristics of HCC patients. Table S12. Cox regression analysis of circSLC3A2 expression as survival predictor of HCC. (DOCX 46 kb
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