1,724,618 research outputs found
Southern (SOU) 4835
No full textA photograph print showing the Southern (SOU) 4835, 2-8-2 (class Ms-4), Charlotte, NC
Erratum: Cormorant Catch Concerns for Fishers: Estimating the Size-Selectivity of a Piscivorous Bird (PLoS ONE (2014) 9:1 (DOI:10.1371/ annotation/b59e978e-722d-4835-9350-f2f92d6f3738)
No full textErratum: Cormorant Catch Concerns for Fishers: Estimating the Size-Selectivity of a Piscivorous Bird (PLoS ONE (2014) 9:1 (DOI:10.1371/ annotation/b59e978e-722d-4835-9350-f2f92d6f3738
Bach à Weimar. AUVIDIS. AV 4835
No full textWeber Edith. Bach à Weimar. AUVIDIS. AV 4835. In: Cahiers de sociologie économique et culturelle, n°6, 1986. p. 152
Block Card 4835 Secor Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4835 Secor Road (Toledo, Ohio) | Dwelling | Franklin Park Area (Toledo, Ohio
Block Card 4835 Bowser Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4835 Bowser Drive (Toledo, Ohio) | Ranch houses | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio
The reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation
No full textInhibition of cyclin-dependent kinases (CDKs) has evolved as an emerging anticancer strategy. In addition to the cell cycle-regulating CDKs, the transcriptional kinases Cdk12 and Cdk13 have become the focus of interest as they mediate a variety of functions, including the transition from transcription initiation to elongation and termination, precursor mRNA splicing, and intronic polyadenylation. Here, we determine the crystal structure of the small molecular inhibitor SR-4835 bound to the Cdk12/cyclin K complex at 2.68 Å resolution. The compound’s benzimidazole moiety is embedded in a unique hydrogen bond network mediated by the kinase hinge region with flanking hydroxy groups of the Y815 and D819 side chains. Whereas the SR-4835 head group targets the adenine-binding pocket, the kinase’s glycine-rich loop is shifted down toward the activation loop. Additionally, the αC-helix adopts an inward conformation, and the phosphorylated T-loop threonine interacts with all three canonical arginines, a hallmark of CDK activation that is altered in Cdk12 and Cdk13. Dose-response inhibition measurements with recombinant CMGC kinases show that SR-4835 is highly specific for Cdk12 and Cdk13 following a 10-fold lower potency for Cdk10. Whereas other CDK-targeting compounds exhibit tighter binding affinities and higher potencies for kinase inhibition, SR-4835 can be considered a selective transcription elongation antagonist. Our results provide the basis for a rational improvement of SR-4835 toward Cdk12 inhibition and a gain in selectivity over other transcription regulating CDKs
Linked collectors and determiners for: A new species and records of Diolenius Thorell, 1870 (Araneae: Salticidae) from New Guinea.
No full textNatural history specimen data linked to collectors and determiners held within, "A new species and records of Diolenius Thorell, 1870 (Araneae: Salticidae) from New Guinea". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a">https://bionomia.net/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a">https://gbif.org/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: A new species and records of Diolenius Thorell, 1870 (Araneae: Salticidae) from New Guinea.
No full textNatural history specimen data linked to collectors and determiners held within, "A new species and records of Diolenius Thorell, 1870 (Araneae: Salticidae) from New Guinea". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a">https://bionomia.net/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a">https://gbif.org/dataset/1490b514-9f31-4835-bfe5-45054cc21c9a</a>. Formatted as a Frictionless Data package
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