1,725,503 research outputs found
Block Card 4718 Violet Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 4718 Violet Street (Toledo, Ohio) | Dwelling | Monroe Acres (Toledo, Ohio) | Franklin Park Area (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Block Card 4718 Rambo Lane
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | Dwelling | 4718 Rambo Lane (Toledo, Ohio) | Secor Woods Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)) | West Toledo Area (Toledo, Ohio
Block Card 4718 Alfred Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4718 Alfred Street (Toledo, Ohio) | Ranch Style | North Toledo (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | Alfred Bailey Addition (Toledo, Ohio
Block Card 4718 Ryan Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4718 Ryan Road (Toledo, Ohio) | Dwelling | Orchard Dale Estates (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters
Get PDFOverexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In this study, we investigated whether VS-4718 could reverse MDR mediated by ABC transporters, including ABCB1, ABCG2, and ABCC1. The results showed that VS-4718 significantly reversed ABCB1- and ABCG2-mediated MDR, but not MDR mediated by ABCC1. Treatment of VS-4718 did not alter the protein level and subcellular localization of ABCB1 or ABCG2. Mechanism studies indicated that the reversal effects of VS-4718 were related to attenuation of the efflux activity of ABCB1 and ABCG2 transporters. ATPase analysis indicated that VS-4718 stimulated the ATPase activity of ABCB1 and ABCG2. Docking study showed that VS-4718 interacted with the substrate-binding sites of both ABCB1 and ABCG2, suggesting that VS-4718 may affect the activity of ABCB1 and ABCG2 competitively. This study provided a novel insight for MDR cancer treatment. It indicated that combination of VS-4718 with antineoplastic drugs could attenuate MDR mediated by ABCB1 or ABCG2 in ABCB1- or ABCG2-overexpressing cancer cells
Linked collectors and determiners for: UPCB herbarium - Universidade Federal de Paraná - Herbário Virtual REFLORA.
No full textNatural history specimen data linked to collectors and determiners held within, "UPCB herbarium - Universidade Federal de Paraná - Herbário Virtual REFLORA". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/339e9de5-ee9a-4718-8837-0bc5b4f933f5">https://bionomia.net/dataset/339e9de5-ee9a-4718-8837-0bc5b4f933f5</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/339e9de5-ee9a-4718-8837-0bc5b4f933f5">https://gbif.org/dataset/339e9de5-ee9a-4718-8837-0bc5b4f933f5</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: The Isometopinae (Hemiptera: Heteroptera: Miridae) of India and Sri Lanka: A Review of the Subfamily, with Descriptions of Six New Species.
No full textNatural history specimen data linked to collectors and determiners held within, "The Isometopinae (Hemiptera: Heteroptera: Miridae) of India and Sri Lanka: A Review of the Subfamily, with Descriptions of Six New Species". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/37ab0d60-c931-4718-b85a-00d5087fca50">https://bionomia.net/dataset/37ab0d60-c931-4718-b85a-00d5087fca50</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/37ab0d60-c931-4718-b85a-00d5087fca50">https://gbif.org/dataset/37ab0d60-c931-4718-b85a-00d5087fca50</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: University of Arizona Insect Collection.
No full textNatural history specimen data linked to collectors and determiners held within, "University of Arizona Insect Collection". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/e36d0997-2f51-4718-b684-16ec092ecd82">https://bionomia.net/dataset/e36d0997-2f51-4718-b684-16ec092ecd82</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/e36d0997-2f51-4718-b684-16ec092ecd82">https://gbif.org/dataset/e36d0997-2f51-4718-b684-16ec092ecd82</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: TUR Lichen collections of Turku University (TUR).
No full textNatural history specimen data linked to collectors and determiners held within, "TUR Lichen collections of Turku University (TUR)". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/be8e2cb0-12ae-4718-9970-2595dca96cfd">https://bionomia.net/dataset/be8e2cb0-12ae-4718-9970-2595dca96cfd</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/be8e2cb0-12ae-4718-9970-2595dca96cfd">https://gbif.org/dataset/be8e2cb0-12ae-4718-9970-2595dca96cfd</a>. Formatted as a Frictionless Data package
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