1,727,806 research outputs found
miR-4324 inhibits ovarian cancer progression by targeting FEN1
No full textAbstract Background Ovarian cancer is one of the most lethal malignancies, with a 1.9% mortality rate worldwide. The dysregulation of the FEN1 gene and miR-4324 has been associated with cancer progression. However, the relationship between miR-4324 and-FEN1 requires further investigation. Methods miR-4324 and FEN1 expressions in ovarian cancer tissues and cell lines were measured via RT-qPCR. The interaction between miR-4324 and FEN1 was assessed using luciferase and RNA pull-down assays. The effects of miR-4324 and FEN1 on cell proliferation, adhesion and apoptosis were determined by CCK-8, BrdU, colony formation, cell adhesion, Caspase-3 and western blot assays in ovarian cancer cell lines CaOV3 and OVCAR3, respectively. Results The results showed that miR-4324 expression was significantly decreased and FEN1 expression was enhanced in ovarian cancer tissues and cell lines. miR-4324 inhibitor promoted cell proliferation, adhesion and migration, and prevented apoptosis. Furthermore, the downregulation of FEN1 inhibited ovarian cancer cell growth and increased apoptosis. miR-4324 inhibited FEN1 expression and repressed ovarian cancer progression. Conclusion Our study found that miR-4324 inhibited FEN1 expression, suppressed cell growth, and increased apoptosis in ovarian cancer cells. Therefore, we identified miR-4324 and FEN1 as potential therapeutic targets for ovarian cancer treatment
Block Card 4324 Kingsbury Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4324 Kingsbury Avenue (Toledo, Ohio) | Tudor Revival Style | Elmwood Park (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio
S.L.C. - South Temple Street P.88
No full textBird\u27s-eye view: Brigham Street / a.k.a. South Temple Street and State Street, Salt Lake City, Utah. View includes: the Hotel Utah (upper left corner), the Church Administration Building / CAB, the Lion House, the Beehive House, and the Eagle Gate. Salt Lake Tribune #4324
Syllabus - REL/HUM 4324 (Spring 2012)
No full textSyllabus for REL/HUM 4324: The Language of Religious Violence. Taught by Prof. Matthew Gabriele (Dept. of Religion and Culture)
Block Card 4324 East Way
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Colonial Revival Style | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4324 East Way (Toledo, Ohio
Block Card 4324 Birchall Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | side gabled folk house | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4324 Birchall Road (Toledo, Ohio) | Folk House Styl
Additional file 1 of miR-4324 inhibits ovarian cancer progression by targeting FEN1
No full textAdditional file 1: Supplementary Table 1. The sequences of miR-4324 inhibitor, miR-4324 mimic, Si-FEN1 and negative control
New star-forming complexes discovered in galaxy NGC 4324
No full textUsing the Caucasus Mountain Observatory, Russian astronomers have investigated a nearby lenticular galaxy known as NGC 4324. They detected young star-forming complexes in the inner ring of this galaxy. The findings, presented October 14 on arXiv.org, could work on our insight about the formation and advancement of NGC 4324.
Located some 85 million light years away in the constellation Virgo, NGC 4324 (also known as UGC 07451) is an early-type lenticular galaxy about 66,000 light years in size. It has a stellar mass of some 56 billion solar masses, while its total mass is estimated to be at least 10 times greater.
Previous observations of NGC 4324 have found that it contains a significant amount of gas and have revealed its remarkable structure — a radiant blue ring of star formation implanted in a large-scale stellar disk typical for lenticular galaxies.
A team of astronomers from the Lomonosov Moscow State University in Russia, drove by Irina Proshina, inspected the pattern of star formation in the ring of NGC 4324. For this purpose, they used the 2.5-m telescope at the Caucasus Mountain Observatory. The study was supplemented by archival images from the SDSS, GALEX and WISE surveys.
"We chose to take full images of the galaxy NGC 4324 in narrow photometric bands focused on the Hα and [NII]λ6583 emission lines with the MaNGaL instrument — a mapper with a tunable filter.... The observations were carried out on April 17, 2018, with the 2.5-m telescope at the Caucasus Mountain Observatory," the researchers wrote in the paper.
All in all, the study detected 18 young star-forming complexes (clumps) with a mean size of about 1,600 light years. The largest clumps ended up having estimated stellar masses reaching 10 million solar masses.
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The results suggest that the starbursts in these clumps have started as of late — within 10 million years. The astronomers explained that the stars that could be shaped during a previous starburst that occurred about 200 million years ago, cannot contribute now to the far-ultraviolet (FUV) luminosity having already detonated, or their luminosity peak has now shifted to the near-ultraviolet (NUV), leading to the observed dunk in the FUV of the clumps.
According to the research, there is a regularity in the distribution of star-forming complexes in the ring of NGC 4324. This suggests that the physical star formation mechanisms over local scales are the same in spiral and lenticular galaxies.
The researchers reasoned that their findings affirm the hypothesis about the possible feeding of the disk in NGC 4324 with gas through the infall of gas-rich satellite galaxies or giant clouds.
"Clumps are framed in the ring because of the gravitational instability, where star formation ignites. The subsequent star formation triggers in the gaseous ring are probably the shock waves from evolving complexes of massive OB stars — the first shaped clusters of young stars in the gaseous clumps. In addition, the infall of a satellite or a giant gas cloud onto the galactic disk can serve as a trigger of another starburst. Thus, the chain of 'gaseous clumps — star complexes' observed by us is a chain of the propagation of star formation both in space (in the ring) and on schedule," the authors of the paper explained
Residence of Tom W. Mewsome, 4324 St. Johns Drive, undated.
No full textAn image of the residence of Tom W Newsome.Alternative title from finding aid. Recto: [typewritten on label affixed to negative] No. 628. Residence of Tom W. Newsome. 4324 St. John's Drive. Dallas, Texas
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