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St. Louis & San Francisco (SLSF) "Frisco" 4306
No full textA photograph print showing the St. Louis and San Francisco (SLSF) "Frisco" 4306, 4-8-2, St. Louis, MO
Additional file 4 of TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavum
No full textAdditional file 4: Figure S4. The SNAI2 inhibits miR-4306 expression to promote the proliferation and fibrosis of HLF cells in vitro. A RT-qPCR was used to detect the miR-4306 expression in HLF cells transfected with vector, miR-4306 inhibitor, and miR-4306 inhibitor + shSNAI2. B The proliferation of HLF cells transfected with vector, miR-4306 inhibitor, and miR-4306 inhibitor + shSNAI2 was determined by CCK-8 assays. C The apoptosis of HLF cells transfected with vector, miR-4306 inhibitor, and miR-4306 inhibitor + shSNAI2 was determined by flow cytometry assays. D Western Blot was used to detect the protein expression of apoptosis-related genes (cleaved caspase3, Bax, and Bcl-2) in HLF cells transfected with vector, miR-4306 inhibitor, and miR-4306 inhibitor + shSNAI2. E Western Blot was used to detect the protein expression of fibrosis-related genes (collagen I, collagen III, MMP2, MMP13, and TGFβ1) in HLF cells transfected with vector, miR-4306 inhibitor, and miR-4306 inhibitor + shSNAI2. miR inh., miR-4306 inhibitor; SNAI2, SNAI2 knockdown adenovirus. #P < 0.05, ##P < 0.01, and ###P < 0.001
Southern Pacific (SP) 4306 on "Sunset Limited"
No full textA photograph postcard showing the Southern Pacific (SP) 4306, 4-8-2, (MT-1), Los Angeles, CA
Block Card 4306 Glendale Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 4306 Glendale Avenue (Toledo, Ohio) | Dwelling | Brookwood Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 4306 Sylvania Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Slaters Franklin Park Sohio | service station | Standard Oil Company | 4306 Sylvania Avenue (Toledo, Ohio) | Moderne Style | Franklin Park Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Platelet microparticles-containing miR-4306 inhibits human monocyte-derived macrophages migration through VEGFA/ERK1/2/NF-κB signaling pathways
No full textPlatelets are major sources of microparticles (MPs) in peripheral bloodstream, and platelet-secreted MPs (P-MPs) transfer biological information to neighboring cells. In the present study, we found that the platelet- and P-MPs-derived microRNA-4306 (miR-4306) expression were downregulated in coronary artery disease (CAD) and platelet-derived miR-4306 was an independent poor prognostic factor in CAD. Plasma miRNA-4306 mainly cofractionated with MPs instead of Argonaute2 complexes or HDL. P-MPs could effectively deliver miR-4306 into human monocyte-derived macrophages (HMDMs). MiR-4306 noticeably inhibited the HMDMs migration in vitro and reduced the number of macrophage cells in cardiac tissue in myocardial infarction mice. This functional impact of miR-4306 was mediated directly through VEGFA to inhibit ERK/NF-κB signaling. In conclusion, our study suggested that intercellular transfer of miR-4306 by platelet microparticles inhibited the HMDMs migration through VEGFA/ERK1/2/NF-κB signaling pathways
Block Card 4306 Holly Hill Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 4306 Holly Hill Drive (Toledo, Ohio) | Glen Ellyn Park (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | Ranch houses | Dwellin
Block Card 4306 Garden Estates Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4306 Garden Estates Drive (Toledo, Ohio) | Ranch houses | Franklin Park Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
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