1,724,324 research outputs found
ORCHIDEE-CAN (revision 4262)
No full text<p>This repository contains the land surface model code, ORCHIDEE-CAN revsion4262, for the publication of 'Simulating damage for wind storms in the land surface model ORCHIDEE-CAN (revision 4262)'.</p>
Block Card 4262 South Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 4262 South Avenue (Toledo, Ohio) | Dwelling | Adams Township Area (Toledo, Ohio) | Folk House Styl
Upregulation of MicroRNA-4262 Targets Kaiso (ZBTB33) to Inhibit the Proliferation and EMT of Cervical Cancer Cells
No full textMore and more studies have reported that dysregulation of microRNAs (miRNAs) leads to the proliferation and EMT of multiple cancers. Recently, several reports have demonstrated that dysregulation of miR-4262 occurs in numerous cancers. However, its role and precise mechanism in human
cervical cancer (CC) have not been well clarified. Hence, this study aimed to explore the biological roles and precise mechanisms of miR-4262 in CC cell lines. The level of miR-4262 was found to be significantly decreased in CC tissues and cell lines. Moreover, decreased expression of miR-4262
was closely related to increased expression of Kaiso (ZBTB33), which belongs to the BTB/POZ family, in CC tissues and cell lines. The proliferation and EMT of CC cells were inhibited by a miR-4262 mimic. However, downregulation of miR-4262 enhanced the proliferation and EMT of CC cells. Next,
bioinformatics analysis predicted that miR-4262 might directly target the Kaiso gene. Besides, luciferase reporter assay had confirmed this result. Moreover, introduction of Kaiso in CC cells partially blocked the effects of miR-4262 mimic. In conclusion, miR-4262 suppressed the proliferation
and EMT of CC cells by directly downregulating Kaiso.</jats:p
Linked collectors and determiners for: Diversidad de orquídeas en la región El Momón-Margaritas-Montebello, Chiapas, México.
No full textNatural history specimen data linked to collectors and determiners held within, "Diversidad de orquídeas en la región El Momón-Margaritas-Montebello, Chiapas, México". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05">https://bionomia.net/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05">https://gbif.org/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Diversidad de orquídeas en la región El Momón-Margaritas-Montebello, Chiapas, México.
No full textNatural history specimen data linked to collectors and determiners held within, "Diversidad de orquídeas en la región El Momón-Margaritas-Montebello, Chiapas, México". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05">https://bionomia.net/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05">https://gbif.org/dataset/698bcafa-eb8e-4262-a0db-f0be58042f05</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Redescription of the ' older Adelopsis' species (Coleoptera: Leiodidae: Cholevinae: Ptomaphagini) based on the analysis of type specimens.
No full textNatural history specimen data linked to collectors and determiners held within, "Redescription of the ' older Adelopsis' species (Coleoptera: Leiodidae: Cholevinae: Ptomaphagini) based on the analysis of type specimens". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f">https://bionomia.net/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f">https://gbif.org/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f</a>. Formatted as a Frictionless Data package
Linked collectors and determiners for: Cowan Tetrapod Collection - Birds.
No full textNatural history specimen data linked to collectors and determiners held within, "Cowan Tetrapod Collection - Birds". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/ba0c046d-52bb-4262-a495-652988c9f3f7">https://bionomia.net/dataset/ba0c046d-52bb-4262-a495-652988c9f3f7</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/ba0c046d-52bb-4262-a495-652988c9f3f7">https://gbif.org/dataset/ba0c046d-52bb-4262-a495-652988c9f3f7</a>. Formatted as a Frictionless Data package
Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing MiR-4262
No full textBackground/Aims: Angiotensin converting enzyme 2 (ACE2) treatment suppresses the severity of acute lung injury (ALI). The effects of ACE2 in ALI have been shown to not only result from its antagonizing hydrolyzing angiotensin II (AngII), which is responsible for reduction in the vascular tension and pulmonary accumulation of inflammatory cells, but also result from a role of ACE2 in suppressing the ALI-induced apoptosis of pulmonary endothelial cells (PECs). Nevertheless, the underlying mechanisms of the role of ACE2 on PEC apoptosis are not completely understood. Methods: Here, we used a bleomycin-induced mouse model for ALI that has been published in our previous studies. We analyzed the mRNA and protein levels of an anti-apoptotic protein Bcl-2 in the ALI-mice that have been treated w/o ACE2. We analyzed miR-4262 levels in the mouse lung in these mice. Bcl-2-targeting miRNAs were predicted using bioinformatics algorithms and a luciferase reporter assay was applied to examine the effects of miR-4262 on the Bcl-2 protein translation upon their binding to 3'-UTR of Bcl-2 mRNA. Adeno-associated viruses carrying either miR-4262 mimics or antisense were injected into ALI-mice without ACE2, and their effects on the apoptosis in mouse lung cells were analyzed by Western blot. Results: ACE2 inhibited the ALI-induced apoptosis of pulmonary cells in vivo partially through upregulation of Bcl-2 protein, but not Bcl-2 mRNA. ACE2 appeared to significantly suppress the upregulation of miR-4262 in mouse lung after ALI. MiR-4262 was found to target 3'-UTR of Bcl-2 mRNA to inhibit its protein translation in PECs. In vivo administration of antisense of miR-4262 decreased apoptosis of pulmonary cells and severity of the ALI in mice. Conclusion: ACE2-induced suppression of miR-4262 partially contribute to the inhibition of the PEC apoptosis after ALI through Bcl-2. MiR-4262 may be a novel promising treatment target for ALI and ARDS
Linked collectors and determiners for: Redescription of the ' older Adelopsis' species (Coleoptera: Leiodidae: Cholevinae: Ptomaphagini) based on the analysis of type specimens.
No full textNatural history specimen data linked to collectors and determiners held within, "Redescription of the ' older Adelopsis' species (Coleoptera: Leiodidae: Cholevinae: Ptomaphagini) based on the analysis of type specimens". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f">https://bionomia.net/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f">https://gbif.org/dataset/729f8a90-e3f7-4262-826f-9849ccf2cf6f</a>. Formatted as a Frictionless Data package
NGC 4262: a Virgo galaxy with an extended ultraviolet ring
No full textContext. The Galaxy Ultraviolet Explorer (GALEX) satellite has recently shown the presence of an extended, outer ring studded with UV-bright knots surrounding the lenticular galaxy NGC 4262. Such a structure-not detected in the optical-is coupled with a ring of atomic (HI) gas.
Aims: We want to show that both star-forming and HI rings surrounding this SB0 galaxy share the same radial distance from the galaxy center and spatial orientation. We also model the kinematics of the ring(s) and of the galaxy body.
Methods: We make use of archive FUV and NUV GALEX data plus HI observations from the literature.
Results: We confirm that the UV-bright and atomic gas rings of NGC 4262 have the same extent and projected spatial orientation. Their kinematics is not coupled with that of the galaxy stars.
Conclusions: It is possible that NGC 4262 has undergone a major gas stripping event in the past that was the origin of the present “necklace” of UV-bright knots
- …
