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    RMDsignatures_exposures_k=13_nFact13_n=4221.csv

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    Regional mutation density (RMD) signatures obtained after appling NMF into a matrix of mutation density across 1Mb windows along the genome for 4221 tumor samples. The values provided (NMF exposures) represent the number of mutations that comes from each specific signature in each sample. The exposures are not normalized.</p

    [Southern Pacific 4221 Train]

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    Photograph of Southern Pacific Railway's 4221 train. The rectangular, two-toned train is lined with many piped and short smokestacks. A tall train front is sat on the right, a ladder along its side and leading to an open entrance. A tall hopper is visible to the left, attached to the back of the train. White smoke stretches out from the smokestacks along the top of the train and in the background to the right

    Block Card 4221 McGregor Lane

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: garrison colonial | 4221 McGregor Lane (Toledo, Ohio) | Dwelling | Concord Woods Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)

    Block Card 4221 East Way

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Greek Revival | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4221 East Way (Toledo, Ohio

    Block Card 4221 Willys Parkway

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Tudor Cottage style | Homeville Subdivision (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4221 Willys Parkway (Toledo, Ohio

    Block Card 4221 Cypress Avenue

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | 4221 Cypress Avenue (Toledo, Ohio) | Dwelling | Estero Place (Toledo, Ohio) | Trilby Area (Toledo, Ohio)

    Block Card 4221 Talwood Lane

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling – Ohio – Toledo | Ranch Style | Plat of Talwood (Toledo, Ohio) | Westgate Area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 4221 Talwood Lane (Toledo, Ohio

    Block Card 4221 Commonwealth Avenue

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4221 Commonwealth Avenue (Toledo, Ohio) | Box bay | Craftsman Style | Commonwealth Addition (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | Folk House Styl

    Efficacy of ERL-4221 as an ovotoxin for feral pigs (\u3ci\u3eSus scrofa\u3c/i\u3e)

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    Context. The expansion of feral pig populations across the United States has increased the occurrence of damage and damage complaints.Newtechniques are needed to more effectively manage feral pig damage, including the development of fertility control agents. Aims. We aimed to assess the ovotoxic properties of ERL-4221 as a candidate fertility control agent for feral pigs. Methods. We conducted two palatability trials to determine ERL-4221 acceptance and one experimental trial with ERL- 4221 at the captive wildlife facility of Texas A&M University-Kingsville during 2008. Our experimental trial had three treatments, a control containing no ERL-4221, baits containing 16.0 mg ERL-4221 kg–1 bodyweight for 10 days, and baits containing 16.0 mg ERL-4221 kg–1 bodyweight for 20 days. Key results. Final body mass, total ovary mass, number of follicles and number of corpora lutea did not differ between treatments. Conclusions. We did not find it efficacious to orally deliver ERL-4221 to feral pigs to reduce fertility. Oral delivery is the most practical, cost-effective means of delivering fertility control agents to feral pigs and development of additional fertility control strategies are needed. Implications. Unless ovotoxic effects of ERL-4221 can be identified in feral pigs, along with a successful means of administration, other fertility control strategies may need to be explored, such as oocyte-secreted proteins that regulate follicular development

    Efficacy of ERL-4221 as an ovotoxin for feral pigs (Sus scrofa)

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    Context The expansion of feral pig populations across the United States has increased the occurrence of damage and damage complaints. New techniques are needed to more effectively manage feral pig damage, including the development of fertility control agents. Aims We aimed to assess the ovotoxic properties of ERL-4221 as a candidate fertility control agent for feral pigs. Methods We conducted two palatability trials to determine ERL-4221 acceptance and one experimental trial with ERL-4221 at the captive wildlife facility of Texas A&amp;M University-Kingsville during 2008. Our experimental trial had three treatments, a control containing no ERL-4221, baits containing 16.0 mg ERL-4221 kg–1 bodyweight for 10 days, and baits containing 16.0 mg ERL-4221 kg–1 bodyweight for 20 days. Key results Final body mass, total ovary mass, number of follicles and number of corpora lutea did not differ between treatments. Conclusions We did not find it efficacious to orally deliver ERL-4221 to feral pigs to reduce fertility. Oral delivery is the most practical, cost-effective means of delivering fertility control agents to feral pigs and development of additional fertility control strategies are needed. Implications Unless ovotoxic effects of ERL-4221 can be identified in feral pigs, along with a successful means of administration, other fertility control strategies may need to be explored, such as oocyte-secreted proteins that regulate follicular development.</jats:p
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