1,725,673 research outputs found
Union Pacific (UP) 4016
No full textA photograph postcard showing Union Pacific (UP) 4016, 4-8-8-4, on mixed freight extra at Borie, WY, 78 cars, 20 mph
Union Pacific (UP) 4016
No full textA photograph postcard showing the Union Pacific (UP) 4016, 4-8-8-4, on westbound freight extra near Dale, WY, 87 cars, 30 mph
Union Pacific (UP) 4016
No full textA photograph postcard showing Union Pacific (UP) 4016, 4-8-8-4, on mixed freight extra, climbimg Sherman Hill near Ozone, WY, 94 cars, 20 mph
Union Pacific (UP) 4016
No full textA photograph postcard showing Union Pacific (UP) 4016, 4-8-8-4, on mixed freight extra, climbing Sherman Hill near Granite Canyon, WY, 94 cars, 20mph
(3) Faculty Commentary on Econ 4016
No full textHeather Kohls of Marquette\u27s Economics Department talks about Econ 4016
NCX-4016 (NO-aspirin) inhibits lipopolysaccharide-induced tissue factor expression in vivo: role of nitric oxide.
No full textBackground— NCX-4016 is an acetylsalicylic acid (ASA) derivative containing a nitric oxide–releasing moiety. Compared with ASA, NCX-4016 has a broader spectrum of antithrombotic and antiinflammatory activities. We hypothesized that NCX-4016 might inhibit in vivo lipopolysaccharide (LPS)-induced expression of tissue factor (TF).
Methods and Results— Rats were administered 90 mg/kg NCX-4016 orally for 5 days. Placebo, 50 mg/kg ASA, and 80 mg/kg isosorbide-5-mononitrate (ISMN) were used in control groups. On day 5, rats were injected intraperitoneally with 100 μg/kg LPS and killed 6 hours later. The expression of TF in monocytes was measured by flow cytometry and Western blot analysis. Reverse transcriptase–polymerase chain reaction was performed to assess expression of TF and cyclooxygenase-2 (COX-2) genes. Plasma concentrations of interleukin-1ß and tumor necrosis factor- were measured. Urine samples were collected to evaluate the excretion of the thromboxane metabolite 11-dehydro-thromboxane (TX)B2. Gastric mucosa was inspected. LPS injection was followed by synthesis TF and COX-2 mRNAs in circulating monocytes, which were blunted by NCX-4016 but not by ASA or ISMN. Both NCX-4016 and ISMN reduced TF expression on surface of circulating monocyte. LPS increased the excretion 11-dehydro-TXB2, and this was prevented by NCX-4016 and ASA. Unlike ASA, NCX-4016 reduced plasma interleukin-1ß and tumor necrosis factor-. In addition, NCX-4016 almost completely prevented mucosal damage, whereas ASA increased the extension of gastric lesions in LPS-injected rats.
Conclusions— NCX-4016 prevents monocyte TF expression; this is accompanied by inhibition of TX and cytokine biosynthesis. These additive effects of nitric oxide release and COX inhibition may help explain efficacy and tolerability of NCX-4016
Block Card 4016 Crary Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4016 Crary Drive (Toledo, Ohio) | Ranch houses | Delrea Place (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio
Block Card 4016 Funston Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 4016 Funston Avenue (Toledo, Ohio) | Bungalow Style | North Toledo (Toledo, Ohio) | Lagrange Area (Toledo, Ohio) | Creekside Addition (Toledo, Ohio
(1) Econ 4016: Bulletin Description
No full textECON 4016. Environmental and Natural Resource Economics 3 sem. hrs. Economic analysis of environmental and natural resources including land, air, and water. Special emphasis on the role of human values and economic institutions in resource exploitation. Topics covered include air and water pollution, energy, ocean resources, forestry practices, mineral resources, the population problem, and agriculture. Prereq: ECON 2003 and ECON 2004
Block Card 4016 Rohr Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 4016 Rohr Drive (Toledo, Ohio) | Ranch houses | Delrea Place (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio
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