1,725,800 research outputs found
A Novel lncRNA HOXC-AS3 Acts as a miR-3922-5p Sponge to Promote Breast Cancer Metastasis
No full textPurpose: The function of long noncoding RNAs (lncRNA) in breast cancer metastasis remains largely unknown. In this work, the role of HOXC-AS3 in breast cancer progression was investigated. Methods: By using Cancer Genome Atlas (TCGA) Database, we investigated the expression of HOXC-AS3 in breast cancer and explored the association between HOXC-AS3 expression and prognosis. Then, we studied the biological function of HOXC-AS3 in cell migration and invasion both in vitro and in vivo. Furthermore, the target miRNA of HOXC-AS3, and the target mRNA of miR-3922-5p were proved. Results: HOXC-AS3 is aberrantly overexpressed in breast cancers especially the HER2+type. Moreover, high expression of HOXC-AS3 has a relationship with poor clinical outcomes of breast cancer. In addition, HOXC-AS3 regulates cell Invasion and migration both in vitro and in vivo. Our results demonstrated that miR-3922-5p was a direct target of HOXC-AS3, and PPP1R1A was a target of miR-3922-5p in breast cancer. Conclusions: The novel lncRNA HOXC-AS3 acts as a miR-3922-5p sponge to upregulate PPP1R1A protein expression, and thus results in promoting breast cancer metastasis. HOXC-AS3 could be a novel therapeutic target for breast cancer therapeutics.</p
Union Pacific (UP) 3922
No full textA photograph postcard showing Union Pacific (UP) 3922, 4-6-6-4, Laramie, WY
Union Pacific (UP) 3922
No full textA photograph postcard showing Union Pacific (UP) 3922, 4-6-6-4, on eastbound freight extra, near Dale Creek, WY, 42 cars, 40 mph
Block Card 3922 Vogel Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 3922 Vogel Drive (Toledo, Ohio) | Folk House Style | Keystone Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio) | Side gable
Block Card 3922 Crary Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 3922 Crary Drive (Toledo, Ohio) | Ranch houses | Keystone Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio) | Hipped roo
Block Card 3922 Donegal Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch Style | 3922 Donegal Lane (Toledo, Ohio) | Dwelling | Dublin Place Addition (Toledo, Ohio) | Trilby Area (Toledo, Ohio)
Block Card 3922 Catawba Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: garage | 3922 Catawba Street (Toledo, Ohio) | North Toledo (Toledo, Ohio) | Creekside Addition (Toledo, Ohio
The Unusual Binary Pulsar PSR J1744-3922
No full textWe report on the study of PSR J1744-3922, a Galactic field binary pulsar exhibiting an unusual combination of characteristics in comparison with other MSPs: a relatively long spin period (172 ms), a relatively high magnetic field (1.7e10 G), a short orbital period (4.6 h) and a light companion (Mmin = 0.08 Msun). These properties are not explained by any of the standard evolution models. This suggests that PSR J1744-3922 has a peculiar evolution history. A few other Galactic field binary pulsars show similar orbital and spin characteristics and we suggest they formed in a related way. Possible formation mechanisms would be: the pulsar originating as a high-magnetic field pulsar; common envelope accretion from a low-mass star that might evolve in an ultra-compact X-ray binary; the accretion-induced collapse of a massive white dwarf. We note that PSR J1744-3922 resembles the unusual globular cluster pulsar PSR B1718-19 that has also been proposed to have been formed by accretion-induced collapse
The Unusual Binary Pulsar PSR J1744-3922
No full textWe report on the study of PSR J1744-3922, a Galactic field binary pulsar exhibiting an unusual combination of characteristics in comparison with other MSPs: a relatively long spin period (172 ms), a relatively high magnetic field (1.7e10 G), a short orbital period (4.6 h) and a light companion (Mmin = 0.08 Msun). These properties are not explained by any of the standard evolution models. This suggests that PSR J1744-3922 has a peculiar evolution history. A few other Galactic field binary pulsars show similar orbital and spin characteristics and we suggest they formed in a related way. Possible formation mechanisms would be: the pulsar originating as a high-magnetic field pulsar; common envelope accretion from a low-mass star that might evolve in an ultra-compact X-ray binary; the accretion-induced collapse of a massive white dwarf. We note that PSR J1744-3922 resembles the unusual globular cluster pulsar PSR B1718-19 that has also been proposed to have been formed by accretion-induced collapse
- …
