1,724,457 research outputs found
Opportunities for linking young surveyors across professional surveying member organisations and FIG
No full textUnion Pacific (UP) 3919
No full textA photograph postcard showing Union Pacific (UP) 3919, 4-6-6-4, Laramie, WY
Union Pacific (UP) 3919
No full textA photograph postcard showing Union Pacific (UP) 3919, 4-6-6-4, on eastbound freight (stockcars) extra, near Kanda, WY, 64 cars, 50 mph
[Veto of H. 3919, R. 188]
No full textThis veto message from Governor Mark Sanford vetoes H. 3919, R. 188, a bill which creates a South Carolina Housing Commission
Block Card 3919 Sylvania Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 3919 Sylvania Avenue (Toledo, Ohio) | apartment houses | Westgate Area (Toledo, Ohio) | Modern Colonial Styl
Block Card 3919 Glendale Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | attached garage | 3919 Glendale Avenue (Toledo, Ohio) | dwelling | Crossgates Plat (Toledo, Ohio) | Byrnedale Area (Toledo, Ohio) | South Toledo (Toledo, Ohio
Block Card 3919 Burton Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3919 Burton Avenue (Toledo, Ohio) | Tudor Cottage style | Almeda Heights Second Addition (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3919 Hoiles Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Homewood Park Extension (Toledo, Ohio) | West Toledo (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | Dwelling (Toledo, Ohio) | Folk House | box bay windows | 3919 Hoiles Avenue (Toledo, Ohio
DataSheet_1_Sulforaphane inhibits the growth of prostate cancer by regulating the microRNA-3919/DJ-1 axis.pdf
No full textBackgroundProstate cancer (PCa) is the second most common solid cancer among men worldwide and the fifth leading cause of cancer-related deaths in men. Sulforaphane (SFN), an isothiocyanate compound, has been shown to exert inhibitory effects on a variety of cancers. However, the biological function of SFN in PCa has not been fully elucidated. The objective of this study was conducted to further investigate the possible underlying mechanism of SFN in PCa using in vitro cell culture and in vivo tumor model experiments.MethodsCell viability, migration, invasion, and apoptosis were analyzed by Cell Counting Kit-8 (CCK-8), wound healing assay, transwell assay, or flow cytometry. Expression of microRNA (miR)-3919 was detected by quantitative real-time polymerase chain reaction (qRT-PCR) or in situ hybridization assay. Xenograft assay was conducted to validated the antitumor effect of miR-3919. The targeting relationship between miR-3919 and DJ-1 was verified by dual-luciferase reporter assay. The level of DJ-1was measured by qRT-PCR or western blotting (WB).ResultsIn the present study, SFN downregulated mRNA and protein expression of DJ-1, an oncogenic gene. Small RNA sequencing analysis and dual-luciferase reporter assay confirmed that microRNA (miR)-3919 directly targeted DJ-1 to inhibition its expression. Furthermore, miR-3919 overexpression impeded viability, migration, and invasion and promoted apoptosis of PCa cells. Tumor growth in nude mice was also inhibited by miR-3919 overexpression, and miR-3919 expression in PCa tissues was lower than that in peritumoral tissues in an in situ hybridization assay. Transfection with miR-3919 inhibitors partially reversed the effects of SFN on cell viability, migration, invasion, and apoptosis. ConclusionOverall, the miR-3919/DJ-1 axis may be involved in the effects of SFN on the malignant biological behavior of PCa cells, which might be a new therapeutic target in PCa.</p
- …
