1,723,884 research outputs found
Astronomische Nachrichten, n° 3898-3912
No full textAstronomische Nachrichten, n° 3898-3912. In: Bulletin astronomique, tome 22, 1905. pp. 155-162
Union Pacific (UP) 3912 & 5083
No full textA photograph postcard showing Union Pacific (UP) 3912, 4-6-6-4, on eastbound freight extra, with 5083, 2-10-2, pushing on rear, near Gateway, UT, 11 miles east of Ogden, UT, 77 cars, 25 mph
Block Card 3912 Vogel Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | Bungalow Style | Craftsman Style | Keystone Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio) | 3912 Vogel Drive (Toledo, Ohio
[Veto of H. 3912, R-417]
No full textThis veto message from Governor Mark Sanford vetoes H. 3912, R-417,a bill that revises several provisions of the Physician Practice Act
Block Card 3912 Airport Highway
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 3912 Airport Highway (Toledo, Ohio) | Vine Gardens (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | Folk House Style | Craftsman Style | Cross Gabled | Dwellin
Block Card 3912 Surrey Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | Dwelling | Talmadge Gardens Addition (Toledo, Ohio) | Westgate Area (Toledo, Ohio) | 3912 Surrey Road (Toledo, Ohio
Jacques Chailley.- Oeuvres vocales SKARBO SK 3912. Diffusion SM
No full textWeber Edith. Jacques Chailley.- Oeuvres vocales SKARBO SK 3912. Diffusion SM. In: Cahiers de sociologie économique et culturelle, n°17, 1992. p. 174
miR-4482 and miR-3912 aim for 3'UTR of ERG mRNA in prostate cancer.
No full textEts-related gene (ERG) is overexpressed as a fusion protein in prostate cancer. During metastasis, the pathological role of ERG is associated with cell proliferation, invasion, and angiogenesis. Here, we hypothesized that miRNAs regulate ERG expression through its 3'UTR. Several bioinformatics tools were used to identify miRNAs and their binding sites on 3'UTR of ERG. The selected miRNAs expression was analyzed in prostate cancer samples by qPCR. The miRNAs overexpression was induced in prostate cancer cells (VCaP) to analyze ERG expression. Reporter gene assay was performed to evaluate the ERG activity in response to selected miRNAs. The expression of ERG downstream target genes was also investigated through qPCR after miRNAs overexpression. To observe the effects of selected miRNAs on cell proliferation and migration, scratch assay was performed to calculate the cell migration rate. miR-4482 and miR-3912 were selected from bioinformatics databases. miR-4482 and -3912 expression were decreased in prostate cancer samples, as compared to controls (p<0.05 and p<0.001), respectively. Overexpression of miR-4482 and miR-3912 significantly reduced ERG mRNA (p<0.001 and p<0.01), respectively) and protein (p<0.01) in prostate cancer cells. The transcriptional activity of ERG was significantly reduced (p<0.01) in response to miR-4482 and-3912. ERG angiogenic targets and cell migration rate was also reduced significantly (p<0.001) after miR-4482 and -3912 over-expression. This study indicates that miR-4482 and -3912 can suppress the ERG expression and its target genes, thereby, halt prostate cancer progression. These miRNAs may be employed as a potential therapeutic target for the miRNA-based therapy against prostate cancer
mRNA expression of ERG targets genes altered in miR-4482 and miR-3912 transfected HUVEC.
No full textmRNA expression of ERG targets genes altered in miR-4482 and miR-3912 transfected HUVEC.</p
- …
