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Jeffreys, Arthur Charles, 3807
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/395102Surname: JEFFREYS. Given Name(s) or Initials: ARTHUR CHARLES. Military Service Number or Last Known Location: 3807. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 10653.228770
Item: [2016.0049.27395] "Jeffreys, Arthur Charles, 3807
Santa Fe (ATSF) 3807
No full textA photograph postcard showing Santa Fe (ATSF) 3807, 2-10-2, eastbound freight, coming down Curtis Hill and crossing the trestle between Heman and Belva, OK, 6:20am, 101 cars, 50 mph. Plains Divisio
Santa Fe (ATSF) 3807 & 1837
No full textA photograph print showing Santa Fe (ATSF) 3807, 2-10-2, on No. 12, on westbound extra starting up hill near Belva, OK. Santa Fe 1837, 2-6-2, helping at rear
Block Card 3807 Schneider Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Split-Level Style | 3807 Schneider Road (Toledo, Ohio) | Dwelling | Crossgates Plat (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3807 Hoiles Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: West Toledo (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | Homewood Park Extension (Toledo, Ohio) | Dwelling (Toledo, Ohio) | Bungalow Style | Craftsman Style | 3807 Hoiles Avenue (Toledo, Ohio
Block Card 3807 Hazelhurst Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Side gabled | Craftsman Style | Homewood Park Extension (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | 3807 Hazelhurst Avenue (Toledo, Ohio) | Folk House Styl
Block Card 3807 Burton Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3807 Burton Avenue (Toledo, Ohio) | Side Gabled | Craftsman Style | pergola | Almeda Heights Second Addition (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio) | Folk House Styl
Block Card 3807 Tall Oaks Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3807 Tall Oaks Road (Toledo, Ohio) | Dwelling | Country Club Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
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Abstract 3807: MicroRNA-29a synergizes with PD-1 therapy to regulate anti-tumor immunity
No full textAbstract CD8 T cells initiate potent anti-tumor immune responses. However, tumor cells employ PD-1 ligand, (PD-L1) to obstruct CD8 T cell responses and drive exhausted T cells (TEX) differentiation. TEX are characterized by sub-optimal functionality and inability to efficiently eliminate tumor cells. Checkpoint inhibitor therapy such as anti-PD-1 can partially restore the effector functions of TEX, but the stable epigenetic programs of TEX lead to the loss of reinvigoration and tumor relapse, providing a challenge for the efficacy of checkpoint blockade therapy. We recently demonstrated that miR-29a acts as a key regulator of TEX differentiation, promotes memory-like differentiation and attenuates exhaustion during chronic infection. Importantly, miR-29a favors the expansion of a progenitor TEX subset expressing the transcription factor TCF-1 that responds to immunotherapy. Therefore, we hypothesized that miR-29a can substantially alter TEX differentiation and synergize with checkpoint blockade to enhance anti-tumor immune responses. A well-established mouse model of chronic infection (LCMV clone-13) was used to induce TEX differentiation, with transcriptional and epigenetic profiles similar to TEX from human tumors. We found that combination of miR-29a overexpression and anti-PD-L1 treatment enhanced CD8 T cell expansion > 20 fold, whereas anti-PD-L1 alone marginally increased the number of CD8 T cells, suggesting that miR-29a synergizes with anti-PD-L1 to enhance CD8 T cell responses. Immune reinvigoration induced by anti-PD-L1 therapy is characterized by a partial reduction of inhibitory receptors and increase in effector responses. Instead, miR-29a overexpression combined with anti-PD-L1 promoted memory-like differentiation and long-term persistence of CD8 T cells, without compromising effector functions. Mechanistically, miR-29a synergized with anti-PD-L1 by inducing expression of a key memory-associated transcription factor, TCF-1, and antagonizing the master epigenetic regulator of exhaustion, TOX. To further understand whether miR-29a promotes only expansion of a progenitor TCF1+ subset or fundamentally alters TEX subset differentiation, equal numbers of miR-29a overexpressing and control TCF1+ CD8 T cells were isolated and adoptively transferred to secondary host mice followed by PD-L1 blockade. TCF1+ CD8 T cells with enforced miR-29a expression responded to PD-L1 blockade more efficiently than control TCF+ CD8 T cells. These results suggest that miR-29a fundamentally alters TEX differentiation by regulating key exhaustion-related transcriptional and epigenetic circuits. Therefore, we suggest that miR29a has the potential to be used as a novel therapeutic inducing robust and durable immune responses upon PD-1 therapy. Citation Format: Xuebing Leng, Svetlana Ristin, Christine Rafie, Lance Buchness, Alejandro Villarino, Erietta Stelekati. MicroRNA-29a synergizes with PD-1 therapy to regulate anti-tumor immunity. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3807
List of the ENS-1 like sequences and homology with the 3807 peptide.
No full text<p>Among 78 copies detected in the chicken genome, 25 were very conserved compared to the reference sequence and are listed below. ORF Finder was used to determine the presence of ORF and to retrieve the subsequent protein sequence. Identity with the 3807 peptide (16 amino acids) defined three categories: total identity (16/16 AA), partial identity (15/16 AA) or no identity (N/A).</p><p>(1) The molecular weight of the protein was calculated with the formula: AA number X 110/1000.</p><p>In bold are indicated the protein sizes detected in CES cell lysates with the 3807 antibody in western-blotting.</p><p>(2) Identity between the ENS-1 like protein sequences and the 3807 peptide (DRIRVLQNEARTRAGK)</p><p>(3) Potential activity based on the presence (Y) or the absence (No) of the Nanog, Gata and Ets transcription factors binding sites controling promoter activity.</p
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