1,726,438 research outputs found
Ct values of miR-146a-3P, miR-550a-3P and miR-3613-3P in CPSP group and non-CPSP group.
No full textCt values of miR-146a-3P, miR-550a-3P and miR-3613-3P in CPSP group and non-CPSP group.</p
Union Pacific (UP) 3525 & 3613
No full textA photograph postcard showing Union Pacific (UP) 3525, 2-8-8-0, on westbound freight extra with loco 3613 pushing at rear, near Nordeen, OR, 75 cars, 15 mph
Block Card 3613 Berkeley Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3613 Berkeley Drive (Toledo, Ohio) | Colonial Revival Style | Willys Park area (Toledo, Ohio) | Extension of Dixon Place (Toledo, Ohio
Block Card 3613 Waldorf Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3613 Waldorf Drive (Toledo, Ohio) | Ranch houses | Ratterrees Boulevard Terrace | Buckeye Basin | North Toledo (Toledo, Ohio
Denver & Rio Grande Western (DRGW) 3557 & 3613
No full textA photograph postcard showing Denver & Rio Grande Western (DRGW) 3557, 2-8-8-2, helping loco 3613 on eastbound freight train near Pando, CO. (Note: loco 3606 passing on westward track.) (see 2008.008.3663
Block Card 3613 Marine Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Lincoln Chemical Research (Toledo, Ohio) | 3613 Marine Road (Toledo, Ohio) | industrial buildings | Air Line Gardens (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Denver & Rio Grande Western (DRGW) 3613
No full textA photograph postcard showing Denver & Rio Grande Western (DRGW) 3613, 2-8-8-2, on eastbound freight extra near Pando, CO, with locos 3557 and 1607 pushing, 58 cars, 15 mph. (See 2008.008.3652
MiR-3613-5p targets AQP4 to promote the progression of chronic atrophic gastritis to gastric cancer
Get PDFIntroduction: Gastric cancer (GC) exhibits high invasiveness, delayed diagnosis, and poor prognosis. Chronic atrophic gastritis (CAG), an initial stage within the Correa cascade, induces gastric mucosal inflammation and atrophy, promoting genetic and epigenetic alterations. MicroRNAs (miRNAs) dysregulation has been implicated in gastric tumorigenesis, yet their specific roles in CAG progression to GC remain unclear.Methods: Using clinical data from the GEO database, we identified miRNAs differentially expressed in gastric mucosa and serum samples from GC patients. Murine CAG models were established through administration of N-methyl-N-nitrosourea (MNU) and high-salt diet (HSD). In vitro functional assays evaluated proliferation and migration after miRNA modulation in gastric cancer cell lines. MiRNA target validation involved luciferase reporter assays.Results: MiR-3613-5p expression was significantly elevated in gastric mucosal and serum samples of GC patients, mucosal tissues of CAG patients, tumor tissues, and human gastric cancer cell lines. Murine models demonstrated increased miR-3613-5p expression in gastric mucosa following MNU and HSD-induced CAG. Functionally, miR-3613-5p overexpression promoted gastric cancer cell proliferation and migration in vitro, whereas silencing miR-3613-5p alleviated pathological gastric mucosal alterations (atrophy, hyperplasia, inflammatory infiltration) in vivo. Mechanistically, miR-3613-5p inhibited Aquaporin 4 (AQP4) expression by directly targeting its 3'UTR.Discussion: Our findings provide the first evidence that miR-3613-5p facilitates CAG progression toward GC via negative regulation of AQP4. These results highlight miR-3613-5p as a promising biomarker and therapeutic target, suggesting antagomiR-3613-5p as a potential novel strategy to prevent gastric carcinogenesis
Gospel Center - Bowling Green, Kentucky (SC 3613)
Get PDFFinding aid only for Manuscripts Small Collection 3613. Two record books, 1937-1947 and 1956-1960, of the Gospel Center, Bowling Green, Kentucky. The books record membership, meeting minutes, and financial data. Also included is a list of baptisms, 1937-1943
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