1,724,064 research outputs found
Atkinson, L, 3526
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/369312Surname: ATKINSON
Given Name(s) or Initials: L
Military Service Number or Last Known Location: 3526
Missing, Wounded and Prisoner of War Enquiry Card Index Number: SEA-1936179354
Item: [2016.0049.01639] "Atkinson, L, 3526
Block Card 3526 Almeda Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3526 Almeda Drive (Toledo, Ohio) | Tudor Cottage style | Almeda Heights (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3526 Prairie Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3526 Prairie Drive (Toledo, Ohio) | Dwelling | Byrne Way Subdivision (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3526 Maxwell Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Moderne | Dwelling | 3526 Maxwell Road (Toledo, Ohio) | Crissey Place Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3526 Hazelhurst Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling (Toledo, Ohio) | Colonial Revival Style | West Toledo (Toledo, Ohio) | Homewood Park Extension (Toledo, Ohio) | Willys Park area (Toledo, Ohio) | 3526 Hazelhurst Avenue (Toledo, Ohio
Block Card 3526 Blairmont Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3526 Blairmont Avenue (Toledo, Ohio) | Dwelling | Glen Arbor (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3526 Terrace Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3526 Terrace Drive (Toledo, Ohio) | Ranch houses | Ratterrees Boulevard Terrace | Buckeye Basin | North Toledo (Toledo, Ohio
Block Card 3526 Havenhurst Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3526 Havenhurst Avenue (Toledo, Ohio) | Dwelling | Glen Arbor (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Elkton Motor Company - Elkton, Kentucky (SC 3526)
Get PDFFinding aid and scan (Click on Additional Files below) for Manuscripts Small Collection 3526. Letter, December 1939, from Elkton Motor Company, Elkton, Kentucky, wishing the recipient a Merry Christmas and suggesting the purchase of a new 1940 Ford V-8 as a family gift. The letterhead features a car wrapped as a Christmas present
Abstract 3526: Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
No full textAbstract
Background: Osteosarcoma accounts for approximately 60% of primary malignant bone tumors diagnosed in the first two decades of life. The use of neo-adjuvant chemotherapy in treating osteosarcoma has improved patients’ average 5 year survival rate from 20% to 70% in the past 30 years. However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy. One of the innovative approaches to addressing MDR is to inhibit MDR1 mRNA expression by RNA interference (RNAi). In order to overcome both the dose-limiting side effects of conventional chemotherapeutic agents and the therapeutic failure resulting from MDR, we designed and evaluated a novel drug delivery system for MDR1 siRNA delivery.
Materials and Methods: Novel biocompatible, lipid-modified dextran-based polymeric nanoparticles were used as the platform for MDR1 siRNA delivery; and the efficacy of combination therapy with this system was evaluated. The mean particle size of the MDR1 siRNA loaded nanoparticles as determined by dynamic light scattering (DLS) measurement was 104.4+3.7 nm and the zeta potential was almost neutral (−0.19+1.13 mV). Multi-drug resistant osteosarcoma cell lines (KHOSR2 and U-2OSR2) were treated with the MDR1 siRNA nanocarriers and MDR1 protein (P-gp) expression, drug retention, and immunofluorescence were analyzed. Combination therapy of the MDR1 siRNA loaded nanocarriers with increasing concentrations of doxorubicin was also analyzed.
Results: We observed that MDR1 siRNA loaded dextran nanoparticles efficiently suppresses P-gp expression in the drug resistant osteosarcoma cell lines. With the delivery of nanoparticles loaded with MDR1 siRNA, growth inhibition with doxorubicin was substantially more marked than with the administration of 100 fold higher amounts of free drugs. The results also demonstrated that this approach may be capable of reversing drug resistance by increasing the amount of drug accumulation in MDR cell lines. Furthermore, subcellular distribution of doxorubicin in MDR cells mimicked that of the drug sensitive variant when nanoparticles were utilized.
Conclusions: Lipid-modified dextran-based polymeric nanoparticles are a promising platform for siRNA delivery. Nanocarriers loaded with MDR1 siRNA are a potential treatment strategy for reversing MDR in osteosarcoma.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3526.</jats:p
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