1,735,948 research outputs found
Santa Fe (ATSF) 3503
No full textA photograph print showing Santa Fe (ATSF) 3503, 4-6-2, on passenger train
Santa Fe (ATSF) 3503
No full textA photograph print showing Santa Fe 3503, 4-6-2, on passenger train, Stillwater, OK
Santa Fe (ATSF) 3503
No full textA photograph print showing Santa Fe 3503, 4-6-2 (BLW), class 3500, on passenger train, Ft. Worth, Tx
Block Card 3503 Beechway Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 3503 Beechway Boulevard (Toledo, Ohio) | Dwelling | Hietts Replat of Part of Beverly Place Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | Tudor Revival Styl
The chemical structures of DCB-3503 and Rac-cryptopleurine.
No full text<p>The chemical structures of DCB-3503 and Rac-cryptopleurine.</p
Block Card 3503 Kenwood Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3503 Kenwood Boulevard (Toledo, Ohio) | Dwelling | Old Orchard Addition, Second Extension (Toledo, Ohio) | Westgate Area (Toledo, Ohio
[Veto of H. 3503, R-146]
No full textThis veto message from Governor Mark Sanford vetoes H. 3503, R-146, a bill dealing with the issuance of special license plates for those serving on a federal board or
commission
The Design of Novel DCB-3503 Analogues: Ligand-Based and Structure-Based Approaches
Full text linkThis research centers around a tylophorine analogue, DCB-3503, a lead compound that possesses potent growth inhibitory activities against all 60 human-derived cell lines screened by the National Cancer Institute (NCI). In comparison with other known antitumor compounds using the NCI’s COMPARE analysis, it is apparent that the compound is acting through a unique mechanism—one decidedly different from that of other known anticancer drugs. Additionally DCB-3503 has shown inhibitory activities against HepG2 (human hepatocellular cancer, HCC), PANC-1 (human pancreatic ductal carcinoma) and chemotherapeutic-resistant KB cell lines in the hands of our collaborator, Dr. Yung-Chi Cheng of Yale University School of Medicine. In order to predict structure–activity relationships, a Comparative Molecular Field Analysis (CoMFA) model was constructed, and several DCB-3503 analogues with higher projected antitumor activities were designed. These analogues included those with modifications at positions 3 and 7, with CoMFA indicating greatest tolerance at the 3-position. Results from biological studies suggested that a more complicated mechanism with different pathways for different analogues was operative. A biotinylated DCB-3503 analogue that was designed and synthesized previously in Dr. David Baker’s lab was utilized by our Yale collaborators to snare a protein targeted by DCB-3503 type compounds. A cellular heat shock cognate protein 70 (Hsc70) was identified as one of the target proteins of DCB-3503 in an anti-hepatitis C virus (HCV) study. The target protein was then synthesized without and with 15N [nitrogen-15] labeling in our lab, and the thermodynamic and NMR studies of its interactions with DCB-3503 were carried out. However, failure to elucidate the specific DCB-3503 and Hsc70 interactions by NMR studies prompted us to turn to computational simulations, where two docking models, including the one based on DCB-3503 and the ATP-state Hsc70 nucleotide binding domain (NBD), and another based on DCB-3503 and the apo-state Hsc70 NBD, were constructed. The most reasonable docking pose of DCB-3503 was generated in the ATP-state protein based on the analysis of both the experimental observations and the docking scores. Design of more promising active candidates can likely be realized in the future through the study of the aforementioned docking pose
NGC 3503 and its molecular environment
Full text linkAims. We present a study of the molecular gas and interstellar dust distribution in the environs of the Hiiπ region NGC 3503 associated with the open cluster Pis 17 with the aim of investigating the spatial distribution of the molecular gas linked to the nebula and achieving a better understanding of the interaction of the nebula and Pis 17 with their molecular environment.
Methods. We based our study on 12CO(1-0) observations of a region of ∼0°6 in size obtained with the 4-m NANTEN telescope, unpublished radio continuum data at 4800 and 8640 MHz obtained with the ATCA telescope, radio continuum data at 843 MHz obtained from SUMSS, and available IRAS, MSX, IRAC-GLIMPSE, and MIPSGAL images.
Results. We found a molecular cloud (Component 1) having a mean velocity of -24.7 km s -1 ,compatible with the velocity of the ionized gas, which is associated with the nebula and its surroundings. Adopting a distance of 2.9 ± 0.4 kpc, the total molecular mass yields (7.6 ± 2.1) × 10 3M⊙ and density yields 400 ± 240 cm -3. The radio continuum data confirm the existence of an electron density gradient in NGC 3503. The IR emission shows a PDR bordering the higher density regions of the nebula. The spatial distribution of the CO emission shows that the nebula coincides with a molecular clump, and the strongest CO emission peak is located close to the higher electron density region. The more negative velocities of the molecular gas (about -27 km s -1), are coincident with NGC 3503. Candidate young stellar objects (YSOs) were detected toward the Hii region, suggesting that embedded star formation may be occurring in the neighborhood of the nebula. The clear electron density gradient, along with the spatial distribution of the molecular gas and PAHs in the region indicates that NGC 3503 is a blister-type Hii region that has probably undergone a champagne phase.Facultad de Ciencias Astronómicas y Geofísica
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