1,724,575 research outputs found
Block Card 3407 Wyckliffe Parkway
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Modern Colonial Style | Dwelling | 3407 Wycliffe Parkway (Toledo, Ohio) | Forest View Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3407 Polk Place
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: dwelling | 3407 Polk Place (Toledo, Ohio) | Cape Cod Style | John L. Gornys Stickney Avenue Addition (Toledo, Ohio) | North Toledo (Toledo, Ohio) | Stickney-Buckeye Area (Toledo, Ohio) | Buckeye Basin (Toledo, Ohio
Block Card 3407 Beechway Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | Beverly Place & Hietts Replat (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | 3407 Beechway Boulevard (Toledo, Ohio) | Tudor Revival Styl
Block Card 3407 Woodley Court
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 3407 Woodley Court (Toledo, Ohio) | Ranch houses | Trail Acres (Toledo, Ohio) | Westgate Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio
Block Card 3407 St. Bernard Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: box house | Dwelling (Toledo, Ohio) | 3407 St. Bernard Drive (Toledo, Ohio) | Dauer Gardens Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Linked collectors and determiners for: Herbier Louis-Marie (QFA) - Collection de lichens.
No full textNatural history specimen data linked to collectors and determiners held within, "Herbier Louis-Marie (QFA) - Collection de lichens". Claims or attributions were made on Bionomia by volunteer Scribes, <a href="http://bionomia.net/dataset/b7a76dbc-3407-467b-96f4-01daae0a6e38">https://bionomia.net/dataset/b7a76dbc-3407-467b-96f4-01daae0a6e38</a> using specimen data from the dataset aggregated by the Global Biodiversity Information Facility, <a href="https://gbif.org/dataset/b7a76dbc-3407-467b-96f4-01daae0a6e38">https://gbif.org/dataset/b7a76dbc-3407-467b-96f4-01daae0a6e38</a>. Formatted as a Frictionless Data package
ME-3407, a new antiulcer agent, inhibits acid secretion by interfering with redistribution of H(+)-K(+)-ATPase
No full text ME-3407 is a newly developed antiulcer drug that markedly promoted the healing of acetic acid-induced chronic ulcers in rats presumably due to potent inhibition of acid secretion. ME-3407 and its metabolites, the sulfoxide of which was preserved, produced dosedependent inhibition of aminopyrine accumulation by rabbit gastric glands stimulated by any agonist, suggesting that the site of their action was downstream from the production of second messengers. Although one of the metabolites, EF-4025, showed some inhibitory effects on functional activities of H(+)-K(+)-ATPase, ME-3407 itself was not a proton pump inhibitor. ME-3407, but not omeprazole, inhibited the stimulation-associated redistribution of H(+)-K(+)-ATPase from microsomes into the apical membranes in addition to delocalizing ezrin, a putative F-actin-membrane linker, from apical plasma membrane. ME-3407 and EF-4025 inhibited myosin light chain kinase (MLCK) and protein kinase A activities. Because another MLCK inhibitor, wortmannin, showed the same properties as ME-3407, i.e., inhibition of aminopyrine accumulation, inhibition of stimulation-associated redistribution of H(+)-K(+)-ATPase, and abnormal distribution of ezrin, we hypothesize that MLCK is one of the potential targets for the drug. We conclude that ME-3407 is a promising drug for treating peptic ulcers, as well as a useful tool for studying mechanisms of parietal cell activation, especially related to the recruitment and recycling of the proton pump. </jats:p
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