1,726,146 research outputs found
Sponge-associated fungi and their bioactive compounds - the Suberites case
Get PDFSpecimens of Suberites domuncula that had been cultured in aquaria for 4 weeks were analyzed for their associated fungi. A total of 81 fungal strains belonging to 20 different genera was isolated and identified by morphological and molecular methods. The most frequently isolated taxa were Cladosporium spp., Penicillium spp., Petriella sp., Phialophora spp. and Engyodontium album. Based on chromatographic and mass spectrometric analysis of fungal extracts, as well as on bioassay results, Aspergillus ustus, Penicillium sp., Petriella sp. and Scopulariopsis sp. were selected for in-depth analysis of their natural products. A total of 19 different fungal metabolites, including three new natural products, was isolated and structurally identified. A. ustus yielded two sesquiterpenes, a drimane derivative and deoxyuvidin, as well as a sesterterpene ophiobolin H. The drimane derivative had an ED50 value against L5178Y cells of 1.9 mu g ml(-1) in vitro. The crude extract of Petriella sp. was also strongly cytotoxic against the L5178Y cell line. The cyclic tetrapeptide WF-3161 was primarily responsible for the activity; the ED50 value was <0.1 mu g ml(-1). It was identical to the known compound WF-3161 and had been previously isolated from Petriella guttulata. In addition to WF-3161, three further natural products were obtained and unequivocally identified as new derivatives of infectopyrone by one-and two-dimensional NMR spectroscopy and by mass spectroscopy. Of the new compounds, only dihydroinfectopyrone was active against L5178Y cells; the ED50 value was 0.2 mu g ml(-1). Penicillium sp. yielded the largest number of metabolites. Viridicatin, viridicatol, cyclopenin and cyclopenol suppressed larval growth of the polyphagous pest insect Spodoptera littoralis when incorporated into an artificial diet at an arbitrarily chosen concentration of 237 ppm. Viridicatol was the most active compound and had an ED50 value of ca. 50 ppm. Scopulariopsis sp. yielded three metabolites, including the known acetylcholinesterase inhibitors quinolactacin A1 and A2
Santa Fe (ATSF) 3161
No full textA photograph print showing Santa Fe 3161, 2-8-2 (BLW), class 3160, Topeka, KS, water tank in background
[Veto of H. 3161, R-95]
No full textThis veto message from Governor Mark Sanford vetoes H 3161, R-95, a bill that reaffirms and furthers the state's unusual control of our public school transportation system
Block Card 3161 Hopewell Place
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Modern Colonial Style | 3161 Hopewell Place (Toledo, Ohio) | Dwelling | Old Orchard Addition (Toledo, Ohio) | Old Orchard Area (Toledo, Ohio
Hays Family Papers (SC 3161)
Get PDFFinding aid and scans (Click on Additional Files below) for Manuscripts Small Collection 3161. Estate papers of the Hays family of Warren County Kentucky: wills of Samuel, Rebecca and Daniel W. Hays; William Hays estate settlement; appraisement of slaves of Daniel Hays; and sale bill of personal property of Rebecca Hays
Block Card 3161 Rocksberry Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | Dwelling | Penrock Place Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | 3161 Rocksberry Avenue (Toledo, Ohio
Block Card 3161 Strathmoor Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Garrison Colonial Style | 3161 Strathmoor Avenue (Toledo, Ohio) | Dwelling | Heather Downs Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3161 Maeterlinck Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3161 Maeterlinck Avenue (Toledo, Ohio) | Dwelling | Heather Downs Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
[Veto of H. 3161, R. 192]
No full textThis veto message from Governor Mark Sanford vetoes H. 3161, R. 192, a bill which raises fees imposed on litigants to file lawsuits, motions, and appeals in order to increase funding for the Judicial Branch
3161. Le Petit Thalamus de Montpellier
No full text3161. Le Petit Thalamus de Montpellier. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). IV. Les Valois, 1328-1461. Paris : A. Picard et fils, 1904. p. 38
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