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Table_1_Exosome-transmitted miR-3124-5p promotes cholangiocarcinoma development via targeting GDF11.docx
No full textObjectiveCholangiocarcinoma (CHOL) is a deadly cancer worldwide with limited available therapies. The aim of this study was to investigate key exosomal miRNAs and their functions in CHOL development.MethodsSerum exosomes were isolated from patients with CHOL and healthy controls, followed by miRNA sequencing for identifying differentially expressed miRNAs (DEMs) and their functions. Then, the expression of key DEMs was experimentally validated in exosomes from clinical CHOL patients and CHOL cells. The effects of overexpression of key DEMs on CHOL cell migration and proliferation were investigated. A key exosomal DEM miR-3124-5p was identified. The effects of overexpression or knockdown of exosomal miR-3124-5p on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) were investigated. Moreover, the function of exosomal miR-3124-5p on tumor growth in vivo was explored.ResultsA total of 632 exosomal DEMs were identified between CHOL and control samples. Target genes of DEMs were significantly enriched in pathways, such as the p53 signaling pathway. miR-3124-5p was upregulated in serum exosomes from CHOL patients and exosomes from CHOL cells, and overexpression of miR-3124-5p promoted RBE cell migration and viability. Moreover, overexpression of exosomal miR-3124-5p promoted the proliferation, migration, and angiogenesis of HUVECs, while knockdown of miR-3124-5p had the opposite effect. miR-3124-5p could target growth differentiation factor 11 (GDF11) and downregulate GDF11 expression. Furthermore, exosomal miR-3124-5p promoted tumor growth in vivo.ConclusionsOur findings revealed that exosome-encapsulated miR-3124-5p promoted the malignant progression of CHOL by targeting GDF11. Exosomal miR-3124-5p and GDF11 could be promising biomarkers or therapeutic targets for CHOL.</p
Astronomische Nachrichten, nos 3124-3132
No full textR. R. Astronomische Nachrichten, nos 3124-3132. In: Bulletin astronomique, tome 10, 1893. pp. 35-40
[Veto of H. 3124, R. 173]
No full textThis veto message from Governor Mark Sanford vetoes H. 3124, R. 173, a bill supporting the expansion of educational choice for all South Carolina students. Unfortunately, a close examination of this bill reveals that it would not provide true choice; it would inhibit it. H. 3124 would actually represent a step backwards in the education reform movement because it would create the illusion of reform where none would actually exist
Block Card 3124 Talmadge Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3124 Talmadge Road (Toledo, Ohio) | Dwelling | Westgate Area (Toledo, Ohio
Block Card 3124 Copland Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3124 Copland Boulevard (Toledo, Ohio) | Dwelling | Chevy Manor (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3124 Villa Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3124 Villa Drive (Toledo, Ohio) | Dwelling | Southern Woods (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3124 Ravenwood Boulevard
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 3124 Ravenwood Boulevard (Toledo, Ohio) | Dwelling | Heather Downs Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3124 Elliott Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Colonial Revival Style | 3124 Elliott Avenue (Toledo, Ohio) | Dwelling | Lincolns Subdivision | Auburndale Area (Toledo, Ohio
Block Card 3124 Orchard Trail Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Dwelling | 3124 Orchard Trail Drive (Toledo, Ohio) | Hipped roof | Orchard Trail Plat 1 (Toledo, Ohio) | Westgate Area (Toledo, Ohio) | West Toledo area (Toledo, Ohio) | Ranch house
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