1,725,095 research outputs found
Lee, 3/3103
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/428124Surname: Lee. Given Name(s) or Initials: . Military Service Number or Last Known Location: 3/3103. Prisoner of War Enquiry Card Index Number: K 294. Division Enquiry: BCOF-NSW. Rank: PTE. Unit: [No Unit]326881
Item: [2016.0049.60386] "Lee, 3/3103
Mechanistic Investigations into the Palladium-Catalyzed Decarboxylative Allylic Alkylation of Ketone Enolates Using the PHOX Ligand Architecture
Get PDFPalladium-catalyzed asymmetric allylic alkylation has become a large and important field for chemical synthesis. Many methodologies in this field offer mild conditions under which challenging and important molecular features can be reliably synthesized, including chiral all-carbon quaternary stereocenters. As a result, palladium- catalyzed asymmetric allylic alkylation has found significant use in total synthesis, and growing use in industry. While the general process of palladium-catalyzed asymmetric allylic alkylation has been studied for decades, there have been a number of recent modifications and developments, such as asymmetric versions of decarboxylative allylic alkylation procedures that are not yet well understood. The development of future implementations and improvements to palladium-catalyzed asymmetric allylic alkylation and related methodologies is expected to be facilitated by a better understanding of these more recent developments, and thus further mechanistic investigation is warranted.
Reported herein is a set of investigations into the palladium-catalyzed decarboxylative asymmetric allylic alkylation of ketone enolates using the PHOX ligand architecture. By monitoring the reaction via 31P NMR, a series of previously unidentified key intermediates is discovered. Two representatives of these key intermediates are isolated and characterized. The solution behavior of these species under reaction-like conditions is studied along with a few novel and related complexes. The role of these intermediates and their impact on the behavior of the reaction and product formation is discussed. Previously confounding experimentally observed behavior for this methodology is rationalized via the properties elucidated for these discovered intermediates.</p
Vom höchsten Gipfel des Piz Lischanna 3103
No full textBlick über den Vadret Lischana, ein heute bis auf eine kleine Fläche an der Südwestflanke des Piz Triazza, genannt Vadret da Triazza, zurückgegangener Gletscher. Im Hintergrund die Berge der OrtlergruppeG. Studer, del. 10. Aug. 1878 ; Lith. F. Lips ; Farbenskizze v. W. BenteliUnten rechts: Jahrbuch des S.A.C. Bd. XIVVgl. "Vom höch Gip d P Lisch[an] 3103", Signatur: [Müller-Wegmann] P 236 und "Von der höchsten Spitze des Pz Lischan", Signatur: [Müller-Wegmann] C 71 und "Vom höchsten Gipfel des Piz Lischanna 3103", Signatur: [Müller-Wegmann] P 243Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SA
Block Card 3103 Glencairn Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 3103 Glencairn Avenue (Toledo, Ohio) | Dwelling | Heather Downs Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Prohibitions and unbinding (Yunnan County 3103; data restriction: B).
No full textProhibitions and unbinding (Yunnan County 3103; data restriction: B).</p
Block Card 3103 Maeterlinck Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3103 Maeterlinck Avenue (Toledo, Ohio) | Dwelling | Heather Downs Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Abstract 3103: Cyclin E amplification predicts sensitivity of primary Uterine Serous Carcinoma (USC) cell lines to the cdk2 inhibitor CYC065
No full textAbstract
We evaluated the in vitro effectiveness of the cdk2 inhibitor CYC065 on multiple primary chemotherapy-resistant USC cell lines with or without CCNE1 amplification.
CCNE1-amplified primary cell lines were significantly more sensitive than wild type USC cell lines to CYC065 in vitro (i.e., IC50: mean±STDV = 61.75±13.22 nM and 103.16± 21.9 nM for CCNE1-amplified USC-ARK-2 and USC-ARK-7 cell lines, respectively and 539.2±182.1 nM for the wild type USC-ARK-4 cell line, p = 0.0048). Consistently, low concentrations of CYC065 (i.e., 100 - 300 nM) caused a dose dependent arrest in the G1 phase of the cell cycle specifically in CCNE1-amplified primary USC cell lines. Importantly, CCNE1 knockdown in the USC-ARK-2 cell line resulted in a 9.29-fold increase in the CYC065 IC50 when compared to the MOCK-transfected USC-ARK-2 cell line (p = 0.021). Finally, when primary CCNE1-amplified USC cell lines also harboring ERBB2 amplification (50% of CCNE1-amplified USC cell lines) were incubated in vitro with the combination of CYC065 and Herceptin (a monoclonal antibody targeting the product of the ERBB2 gene, HER2/neu), an increased inhibitory effect was reported in the combination treatment when compared to Herceptin or CYC065 used as single agent (i.e.,% viable cells: mean±STDV = 71.4±0.85, 65.4±14.2, 42.2±2.1 for the Herceptin, the CYC065 and the combination treatment on USC-ARK-2, respectively; p = 0.014).
Together these findings identify CYC065 as a promising drug to be considered alone or in combination in the treatment of patients harboring CCNE1-amplified USC.
Citation Format: Emiliano Cocco, Stefania Bellone, Salvatore Lopez, Elena Bonazzoli, Federica Predolini, Jonathan D. Black, Alessandro D. Santin. Cyclin E amplification predicts sensitivity of primary Uterine Serous Carcinoma (USC) cell lines to the cdk2 inhibitor CYC065. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3103. doi:10.1158/1538-7445.AM2015-310
Vom höchsten Gipfel des Piz Lischanna 3103
No full textBlick über den Vadret Lischana, ein heute bis auf eine kleine Fläche an der Südwestflanke des Piz Triazza, genannt Vadret da Triazza, zurückgegangener Gletscher. Im Hintergrund die Berge der OrtlergruppeG. Studer, del. 10. Aug. 1878 ; Lith. F. Lips ; Farbenskizze v. W. BenteliUnten rechts: Jahrbuch des S.A.C. Bd. XIVGehört zu den Ansichten und Panoramen, die früher als Doubletten bezeichnet wurden. Es handelt sich jedoch um feiner oder weiter ausgearbeitete Zeichnungen, Vorstufen zu Reinzeichnungen oder Sammlungsstücken, die bisher weder katalogisiert noch signiert wurdenVgl. "Vom höch Gip d P Lisch[an] 3103", Signatur: [Müller-Wegmann] P 236 und "Von der höchsten Spitze des Pz Lischan", Signatur: [Müller-Wegmann] C 71 und "Vom höchsten Gipfel des Piz Lischanna 3103", Signatur: [Müller-Wegmann] C 72Aus der Sammlung Johann Müller-Wegmann; Depositum der SAC Sektion Uto in der Zentralbibliothek des SA
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