1,725,355 research outputs found
Resumen ejecutivo de los documentos ALADI/SEC/di 3028 y 3029
No full textSecretaría General de la ALADI.Informe mensual sobre el comportamiento del gasto presupuestal para el período enero-abril 2022 (ALADI/SEC/di 3028) -- Informe sobre la situación financiera de la Asociación al 30 de abril de 2022 (ALADI/SEC/di 3029)
Resumen ejecutivo de los documentos ALADI/SEC/di 3028 y 3029
No full textSecretaría General de la ALADI.Informe mensual sobre el comportamiento del gasto presupuestal para el período enero-abril 2022 (ALADI/SEC/di 3028) -- Informe sobre la situación financiera de la Asociación al 30 de abril de 2022 (ALADI/SEC/di 3029)
Chicago & North Western (CNW) 3029
No full textA photograph print showing Chicago & Northwestern (CNW) 3029, 4-8-4 Class H BLW), Proviso, IL
Block Card 3029 Maeterlinck Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 3029 Maeterlinck Avenue (Toledo, Ohio) | Dwelling | Heather Downs Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3029 Villa Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 3029 Villa Drive (Toledo, Ohio) | Dwelling | Southern Woods (Toledo, Ohio) | South Toledo Area (Toledo, Ohio
Block Card 3029 Laskey Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Saltbox houses | Dwelling | 3029 Laskey Road (Toledo, Ohio) | Elmhurst Park Addition (Toledo, Ohio) | Deveaux Area (Toledo, Ohio) | West Toledo (Toledo, Ohio
Block Card 3029 Strathmoor Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: 3029 Strathmoor Avenue (Toledo, Ohio) | Dwelling | Heather Downs Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio) | Folk House Style | Side gable
Block Card 3029 Chestnut Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Front Gabled Folk House Style | dwelling | 3029 Chestnut Street (Toledo, Ohio) | Ashland Addition (Toledo, Ohio) | North Toledo (Toledo, Ohio
Abstract 3029: Biochemical evidence towards the existence of an oncogenic Hsp90 complex
No full textAbstract
To maintain homeostasis, cells employ intricate molecular machineries comprised of thousands of proteins programmed to execute well-defined functions. Dysregulation of these pathways, through protein mis-expression or mutation, provides biological advantages that confer the malignant phenotype. At the molecular level, this requires cells to invest energy in maintaining the stability and function of these proteins, and for this reason cancer cells co-opt molecular chaperones, including Hsp90. Hsp90 is recognized to play important roles in maintaining the transformed phenotype - the chaperone and its associated co-chaperones assist in the correct folding of cellular proteins, collectively referred to as “client proteins,” many of which are effectors of signal transduction pathways controlling cell growth, differentiation, the DNA damage response, and cell survival. Tumor cell addiction to these proteins (i.e. through mutations, aberrant expression, improper cellular translocation, etc) thus makes them critically reliant on Hsp90. While Hsp90 is expressed in all cells and tissues, it was shown that tumors preferentially contain Hsp90 that is in a higher order multi-chaperone complex with high affinity for certain Hsp90 inhibitors, while normal tissues harbor a latent, uncomplexed Hsp90 that has low affinity for these inhibitors. We here extend this model and propose that Hsp90 forms biochemically distinct complexes in cancer cells. In this view, a major fraction of cancer cell Hsp90 retains “house keeping” chaperone functions similar to normal cells, whereas a functionally distinct Hsp90 pool enriched or expanded in cancer cells specifically interacts with oncogenic proteins required to maintain tumor cell survival. Perhaps this Hsp90 fraction represents a cell stress specific form of chaperone complex that is expanded and constitutively maintained in the tumor cell context. Our data suggest that it may execute functions necessary to maintain the malignant phenotype. One such role is to regulate the folding of mutated (i.e. mB-Raf) or chimeric proteins (i.e. Bcr-Abl). We here also present experimental evidence for an additional role; that is, to facilitate scaffolding and complex formation of molecules involved in aberrantly activated signaling complexes.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3029. doi:1538-7445.AM2012-302
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