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    [IO Islamic 2954] Khazâna-i-'âmirah

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    Khazâna-i-’âmirah. This manuscript is now IO Islamic 687 in the India Office collections. [metadata: Hermann Ethé, Catalogue of Persian Manuscripts in the Library of the India Office, 2 vols. (Oxford: India Office, 1903): volume 1, number 2954 here with notations and hyperlinks]. 687 The same. Another excellent copy, without a date. Complete index on ff. 1a-6a. Beginning of the tadhkirah in the middle of fol. 6a. No. 2954, ff. 376, ll. 15; large and distinct Nasta’lîḳ; size, 113/8 in. by 7 in

    2954. Bataille de Courtrai (11 juillet 1302)

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    2954. Bataille de Courtrai (11 juillet 1302). In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. pp. 219-220

    Male-Biased gga-miR-2954 Regulates Myoblast Proliferation and Differentiation of Chicken Embryos by Targeting YY1

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    Previous studies have shown that gga-miR-2954 was highly expressed in the gonads and other tissues of male chickens, including muscle tissue. Yin Yang1 (YY1), which has functions in mammalian skeletal muscle development, was predicted to be a target gene of gga-miR-2954. The purpose of this study was to investigate whether gga-miR-2954 plays a role in skeletal muscle development by targeting YY1, and evaluate its function in the sexual dimorphism development of chicken muscle. Here, all the temporal and spatial expression profiles in chicken embryonic muscles showed that gga-miR-2954 is highly expressed in males and mainly localized in cytoplasm. Gga-miR-2954 exhibited upregulated expression of in vitro myoblast differentiation stages. Next, through the overexpression and loss-of-function experiments performed in chicken primary myoblasts, we found that gga-miR-2954 inhibited myoblast proliferation but promoted differentiation. During myogenesis, gga-miR-2954 could suppress the expression of YY1, which promoted myoblast proliferation and inhibited the process of myoblast cell differentiation into multinucleated myotubes. Overall, these findings reveal a novel role of gga-miR-2954 in skeletal muscle development through its function of the myoblast proliferation and differentiation by suppressing the expression of YY1. Moreover, gga-miR-2954 may contribute to the sex difference in chicken muscle development

    Block Card 2954 Jermain Drive

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Garrison colonial | 2954 Jermain Drive (Toledo, Ohio) | Dwelling | Kingston Addition | Auburndale Area (Toledo, Ohio

    Block Card 2954 Oxbridge Drive

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Shingle style | 2954 Oxbridge Drive (Toledo, Ohio) | Dwelling | Subdivision of Woodward Heights (Toledo, Ohio) | South Toledo Area (Toledo, Ohio

    2954. Bataille de Courtrai (11 juillet 1302)

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    2954. Bataille de Courtrai (11 juillet 1302). In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. pp. 219-220

    Michael Pisaro's 'pi (1-2954)'

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    Five performances on consecutive days of American experimental composer Michael Pisaro's 'pi (1-2954)' for solo piano. Composer's note: pi (1–2954) is a collection of fifteen solos for piano using a simple formula for playing the decimal places of . The formula takes a fundamental five-second unit and divides it into ten equal parts (written as eighth notes). Starting at the first position (beat one) the pianist plays a tone (with pedal depressed) the number of times indicated by the decimal place (i.e., if 1, then just once, if 9 then nine times in a row, for 0 then not at all during that unit). The duration of the gap between places thus also varies, but there will always be a gap of at least one place or eighth-note beat. The fifteen solos encompass first 2954 decimal places (not including the number 3 before the decimal). While this is not a particularly efficient method for getting through pi (it would take about 83,333 hours to play “only” the first million places), I have found that it is a good way to investigate the subtle shadings of piano timbre created by minutely different patterns of repetition–and to allow the patterns themselves to (perhaps just barely) be heard as music. The fifteen pieces are organized according to three different vectors, as pi itself is often understood not just as a list of places, but one that has certain qualities and intensities. One vector is a sequential passage through the 2954 places (starting of course with .141592…). Another vector is the subdivision of the space of the piano. A different tone is assigned to each of the 15 pieces (i.e., one tone per piece), Through the series these tones move irregularly outward from the central tone of the piano (e4 above middle c), with some preference given to tones in the central range of the piano (a register which seems to combine resonance and clarity). Finally, the pieces each have different duration: the shortest being 5’00” and the longest 54’10” (this one is actually the piece that begins the series of decimal places)–and as with the pitch series, the relationship between the decimal places performed and the duration is non-linear

    Block Card 2954 Penrose Avenue

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    This image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cape Cod Style | 2954 Penrose Avenue (Toledo, Ohio) | Dwelling | Miami Heights Addition (Toledo, Ohio) | South Toledo Area (Toledo, Ohio

    miR-2954 Inhibits PI3K Signaling and Induces Autophagy and Apoptosis in Myocardium Selenium Deficiency

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    Background/Aims: Selenium (Se) deficiency can lead to several cardiac diseases, including Keshan disease in humans, mulberry heart disease in pigs and cardiac injury in chickens. MicroRNAs have been a research focus in recent years and have been shown to participate in a new avenue of cell death-autophagy, which can play a significant role in several types of heart disease. Methods: MicroRNAome analysis showed that the expression of miR-2954 was increased in the myocardium of selenium-deficient chickens, and PI3K was predicted to be the target gene. The target relationship between miR-2954 and PI3K was verified with a double fluorescence enzyme assay and RNA Protein Interaction Prediction and molecular docking software. qRT-PCR and western blotting were used to detect the expression of PI3K and related pathway components in selenium-deficient chickens and miR-2954 knockout/overexpression cardiomyocytes. Results: In this study, we observed that miR-2954 overexpression led to inhibition of PI3K pathway in vivo and in vitroled to inhibition of the PI3K pathway in vivo and in vitro. Conclusion: The expression of miR-2954 was increased in selenium-deficient myocardium, whereas overexpression of miR-2954 led to autophagy and apoptosis of myocardial cells during cardiac injury through regulation of the PI3K pathway; whether this phenomenon is a self-protection mechanism of the organism or damage caused by miR-2954 requires further study. Our findings provides new insight apoptosis in cardiomyocytes; additionally, we aim to provide a new direction for the diagnosis and targeted treatment of myocardial diseases
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