1,727,771 research outputs found
A High-Yielding Synthesis of EIDD-2801 from Uridine
No full textA simple reordering of the reaction sequence allowed the improved synthesis of EIDD-2801, an antiviral with promising activity against the SARS-CoV-2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17% to 61%, and fewer isolation/purification steps were needed. In addition, a continuous flow procedure for the final acetonide deprotection was developed, which proved to be favorable toward selectivity and reproducibility.<br /
Chicago, Burlington & Quincy (CBQ) 2801
No full textA photograph print showing Chicago, Burlington & Quincy (CBQ) 2801, 4-6-2, S1, Chicago, IL
A Concise Route to MK-4482 (EIDD-2801)
No full textA two-step route to MK-4482 (EIDD-2801, 1) was developed consisting of an
esterification and hydroxamination of cytidine.
The reactions can be conducted in either order with overall yields of
67% (first step—esterification) and 37% (first step—hydroxamination). Selective
esterification of the nucleoside’s primary alcohol by enzymatic means
eliminated the need for diol protection/deprotection, and direct transamination
with hydroxylamine precluded the necessity of activating the nucleobase for
amine coupling. This results in a significant
advancement over the reported synthesis which is formed in at best 17%
yield. The step count is reduced from
five transformation to two, and the more expensive uridine is replaced with the
more available cytidine
Block Card 2801 Wicklow Road
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 2801 Wicklow Road (Toledo, Ohio) | attached garage | Old Orchard Addition, Third Extension (Toledo, Ohio) | Westgate Area (Toledo, Ohio
Block Card 2801 Rathbun Drive
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: English Cottage Style | 2801 Rathbun Drive (Toledo, Ohio) | Dwelling | Parkdale Addition | Auburndale Area (Toledo, Ohi
Block Card 2801 Lawrence Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Cross gabled | 2801 Lawrence Avenue (Toledo, Ohio) | Dwelling | Cushings Utopian Addition (Toledo, Ohio) | Auburndale Area (Toledo, Ohio) | Folk House Styl
Block Card 2801 Lincolnshire Boulevard West
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 2801 Lincolnshire Boulevard West (Toledo, Ohio) | attached garage | Old Orchard Addition, Third Extension (Toledo, Ohio) | Westgate Area (Toledo, Ohio
Block Card 2801 Lincolnshire Boulevard East
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Ranch houses | 2801 Lincolnshire Boulevard East (Toledo, Ohio) | attached garage | Old Orchard Addition, Third Extension (Toledo, Ohio) | Westgate Area (Toledo, Ohio
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