1,728,953 research outputs found
Astronomische nachrichten, nos 2795-2797
No full textR. R. Astronomische nachrichten, nos 2795-2797. In: Bulletin astronomique, tome 4, 1887. pp. 404-408
Bayonet Briefing Room N Exterior Bldg. 2797
No full textStill image of Bayonet Briefing Room, Bldg. 2797, North exterior.https://digitalcommons.csumb.edu/fortord_images/1340/thumbnail.jp
Bayonet Briefing Room Schematic Bldg. 2797
No full textSchematic of Bayonet Briefing Room, Bldg. 2797. Black and white image.https://digitalcommons.csumb.edu/fortord_images/1341/thumbnail.jp
2797. Chronique dite de Baudouin d'Avesnes
No full text2797. Chronique dite de Baudouin d'Avesnes. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). III. Les Capétiens, 1180-1328. Paris : A. Picard et fils, 1903. pp. 175-176
Promissory Note - Allegany County, Maryland (SC 2797)
Get PDFFinding aid only for Manuscripts Small Collection 2797. Promissory note and bond from an unknown obligant (bottom half torn), given to John Sigler for 30 pounds, payable in grain
Bayonet Briefing Room, E Exterior 1 Bldg. 2797
No full textStill image of Bayonet Briefing Room, Bldg. 2797, East exterior.https://digitalcommons.csumb.edu/fortord_images/1339/thumbnail.jp
Bayonet Briefing Room, Former E Exterior Bldg. 2797
No full textStill image of Bayonet Briefing Room, Bldg. 2797, former East exterior.https://digitalcommons.csumb.edu/fortord_images/1337/thumbnail.jp
Bayonet Briefing Room, E Exterior 2 Bldg. 2797
No full textStill image of Bayonet Briefing Room, Bldg. 2797, East exterior.https://digitalcommons.csumb.edu/fortord_images/1338/thumbnail.jp
Aminopeptidase inhibition by the novel agent CHR-2797 (tosedostat) for the therapy of acute myeloid leukemia
No full textAminopeptidase enzyme inhibition is thought to deplete the free intracellular amino acids needed by malignant cells for growth and development, resulting in profound anti-proliferative and apoptotic effects. In this study, we investigated the effects of the metalloenzyme-inhibitor CHR-2797 (tosedostat), in primary acutemyeloidleukemia (AML) cells. CHR-2797 demonstrated marked in vitro cytotoxicity in AML samples and strong synergy with Cytarabine (Ara-C), but significantly less cytotoxicity to normal marrow progenitors. Furthermore mechanistic investigations revealed that CHR-2797 inhibited the intrinsic nuclear, cytoplasmic and cell surface aminopeptidase function of AML blasts in a dose-dependent manner, demonstrating a promising novel approach for AML therapy
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