1,729,155 research outputs found
K.2143+
No full textK.2143 + K.10844 + K.10351 + K.20001
Photographs by the Shumma alu team (FNS projects nos. 175970 and 205122
NPS-2143 - Treatment of osteoporosis - Calcilytic
No full textEfforts to discover new treatments for osteoporosis led to the identification of the potent and selective, small-molecule calcium receptor antagonist NPS-2143. NPS-2143 is the prototype calcilytic drug, designed to act on calcium receptors on the surface of parathyroid glands, stimulating the release of the body's own stores of native parathyroid hormone (PTH). In osteopenic ovariectomized rats, daily oral administration of NPS-2143 resulted in moderate but sustained increases in plasma PTH levels and marked increases in bone formation and resorption, with no net bone gain or loss. The combination of NPS-2143 and estrogen increases bone formation and density to a greater extent than either agent alone. These results suggest that NPS-2143 may be useful in the treatment of established osteoporosis
2143. Chronicon breve Hierosolymitanum
No full text2143. Chronicon breve Hierosolymitanum. In: Molinier Auguste. Les Sources de l'histoire de France - Des origines aux guerres d'Italie (1494). II. Époque féodale, les Capétiens jusqu'en 1180. Paris : A. Picard et fils, 1902. p. 291
Chicago, Rock Island & Pacific (RI) 2143 (neg)
No full textA photograph negative showing the Chicago, Rock Island & Pacific (CRIP, RI, or ROCK) 2143, 2-8-0, Kansas City, KS
Sucrose Accumulation Maturity Curves for CP 89-2143
No full textThis fact sheet presents the sucrose accumulation maturity curves for different crop ages (plant cane, 1st ratoon, and 2nd ratoon) of CP 89-2143. CP 89-2143 harvest samples were collected at 2-week intervals at 5 locations over 4 harvest seasons in the Everglades Agricultural Area. Biomass and sugar yields were determined on all samples in order to generate SPT trends over time. A full comparison of CP 89-2143 SPT trends with 12 other CP cultivars may be found in EDIS publication SS-AGR-221 Maturity Curves and Harvest Schedule Recommendations for CP Sugarcane Varieties (http://edis.ifas.ufl.edu/SC069). This document is SS-AGR-220, one of a series of the Agronomy Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Published April 2004. Reviewed March 2005.
SSAGR220/SC068: Sucrose Accumulation Maturity Curves for CP 89-2143 (ufl.edu
Block Card 2143 Evansdale Avenue
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: garage | Evansdale Addition (Toledo, Ohio) | Colony Area (Toledo, Ohio) | 2143 Evansdale Avenue (Toledo, Ohio
NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation
No full textNPS 2143, a novel and selective antagonist of calcium-sensing receptor (CaSR) has been reported to possess anti-inflammatory activity. In the present study, we examined the protective effect of NPS 2143 on lipopolysaccharide (LPS)-induced acute lung injury (ALI). NPS 2143 pretreatment significantly inhibited the influx of inflammatory cells and the expression of monocyte chemoattractant protein-1 (MCP-1) in the lung of mice with LPS-induced ALI. NPS 2143 decreased the levels of neutrophil elastase (NE) and protein concentration in the bronchoalveolar lavage fluid (BALF). NPS 2143 also reduced the production of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the BALF and serum. In addition, NPS 2143 attenuated the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and increased the activation of AMP-activated protein kinase (AMPK) in the lung. NPS 2143 also downregulated the activation of nuclear factor-kappa B (NF-κB) in the lung. In LPS-stimulated H292 airway epithelial cells, NPS 2143 attenuated the releases of IL-6 and MCP-1. Furthermore, NPS 2143 upregulated the activation of AMPK and downregulated the activation of NF-κB. These results suggest that NPS 2143 could be potential agent for the treatment of inflammatory diseases including ALI.
Block Card 2143 Perth Street
No full textThis image was produced by the Auditor's Office in Lucas County, Ohio for tax assessment purposes. Associated dates are approximate. Descriptive terms related to this photograph include: Modern Colonial Style | 2143 Perth Street (Toledo, Ohio) | Dwelling | Evansdale Addition (Toledo, Ohio) | Colony Area (Toledo, Ohio
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