1,742,181 research outputs found
Cathédrale Notre-Dame, Amiens, 1236
No full textPhotographie: Hartill Art Associates. AFr-0823; Date du début des travaux de réalisation : 1236
Cathédrale Notre-Dame, Amiens, 1236
No full textPhotographie: Hartill Art Associates. AFr-0825; Date du début des travaux de réalisation : 1236
miR-1236 regulates hypoxia-induced epithelial-mesenchymal transition and cell migration/invasion through repressing SENP1 and HDAC3
No full textIntratumoral hypoxia induces epithelial-mesenchymal transition and promotes cancer metastasis. MicroRNAs (miRNAs) are endogenous, single-strand RNA molecules that regulate gene expression. MiRNAs control cell growth, proliferation, differentiation and cell death and may function as oncogenes or tumor suppressors. HDAC3 and SENP1 are two molecules involved in hypoxia-induced EMT and HIF-1 alpha stability, respectively. In this report, we show that miR-1236 plays a critical role in hypoxia-induced EMT and metastasis. MiRNA prediction programs TargetScan and miRanda show that miR-1236 may target HDAC3 and SENP1. MiR-1236 represses the luciferase activity of reporter constructs containing 3'UTR of HDAC3 and SENP1 as well as the expression levels of HDAC3 and SENP1. MiR-1236 abolishes hypoxia-induced EMT and inhibits migration and invasion activity of tumor cells. Hypoxia represses miR-1236 expression. The promoter region of miR-1236 is identified as the NELFE promoter. Twist1, an EMT regulator activated by hypoxia/HIF-1 alpha, is shown to repress the reporter construct driven by the NELFE promoter. The binding site of Twist1 in the NELFE promoter is identified and chromatin immunoprecipitation assays show the direct binding of Twist1 to this site. Overexpression or knockdown of Twist1 in stable cell lines shows the inverse correlation between Twist1 and miR-1236 expression. These results identify a miRNA that regulates hypoxia-induced EMT and metastasis through repressing HDAC3 and SENP1 expression and present a regulatory network that involves many key players in hypoxia-induced EMT. (C) 2016 Elsevier Ireland Ltd. All rights reserved
miR-1236-3p suppresses the anti-bacterial viability of macrophages against mycobacterium tuberculosis by targeting toll-like receptor 4
No full textThis document is an additional material for " miR-1236-3p suppresses the anti-bacterial viability of macrophages against mycobacterium tuberculosis by targeting toll-like receptor 4 ".</p
CCC Company 1236
No full textGroup portrait of company 1236 near Wallace and Prichard, Idaho. The writing on the phot reads: "CCC Company 1236 Camp F-132 Big Creek Number 2 Idaho."F-132C-123
Resolución UNRN Nº 1236/2010. Aprobar el Reglamento Interno para la carrera de Maestría en Comunicación para el Desarrollo
No full textFil: Universidad Nacional de Río Negro (U). Universidad Nacional de Río Negro. Río Negro, ArgentinaResolución UNRN Nº 1236/2010. Aprobar el Reglamento Interno para la carrera de Maestría en Comunicación para el Desarrollo.fals
McKinley, Sue (FA 1236)
Full text linkFinding aid only for Folklife Archives Project 1236. Student paper titled “The Early Schools of Taylor County” in which Sue McKinley charts the rise and fall of traditional one-room school houses throughout Taylor County, Kentucky. McKinley examines the lasting influence the schoolhouses had on the community, as well as factors that contributed to the success of educational programs throughout the county. The author also describes the structure of a typical school day, the consolidation of rural schools and districts, and the importance of properly trained teachers. The paper includes black and white photographs of multiple one-room schoolhouses with a brief description of each location
EC80-1236 Turfgrass Diseases
Full text linkExtension Circular 80-1236: This circular is about different turfgrass diseases
Lobb, George William, 5/1236
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/428136Surname: Lobb. Given Name(s) or Initials: George William. Military Service Number or Last Known Location: 5/1236. Prisoner of War Enquiry Card Index Number: K.89. Division Enquiry: WA. Rank: PTE. Unit: Korea326893
Item: [2016.0049.60398] "Lobb, George William, 5/1236
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