203 research outputs found
Erna Fergusson
No full textPortrait of a child (full-length), identified as Erna Fergusson (later a well known New Mexican author), in costume for a Washington's Birthday party sponsored by the Ilfeld family. Three different images on printing-out paper; studio mount car
ERNA and Friedman's reverse mathematics
No full textElementary Recursive Nonstandard Analysis, in short ERNA, is a constructive system of nonstandard analysis with a PRA consistency proof, proposed around 1995 by Patrick Suppes and Richard Sommer. Recently, the author showed the consistency of ERNA with several transfer principles and proved results of nonstandard analysis in the resulting theories (see [12] and [13]). Here, we show that Weak Konig's lemma (WKL) and many of its equivalent formulations over RCA(0) from Reverse Mathematics (see [21] and [22]) can be 'pushed down' into the weak theory ERNA. while preserving the equivalences, but at the price of replacing equality with equality 'up to infinitesimals'. It turns out that ERNA plays the role of RCA(0) and that transfer for universal formulas corresponds to WKL
Erna van Duren and Michael Cox
No full textErna van Duren and Michael Cox holding their publication "Responsible Leadership and Strategic Management" at the Campus Author Recognition Program annual reception, October 27, 2011
Memorandum : betr. die Sicherung und Erschliessung der Quellen zur juedischen Kulturgeschichte und Familienkunde.
No full textDocument about the proposed establishment of a center for German Jewish culture and genealogy in Berlin or HamburgdigitizedThe manuscript has been removed from the ‘Lehranstalt fuer die Wissenschaft des Judentums Collection’, AR 11844Born in Hamburg on February 26, 1896, Erna Magnus was a social worker who was engaged in an historical study of the Jewish community of Hamburg during the 1930s. She emigrated to the United States in 1939, where she held various social work and teaching position
The Public Land System of Norwalk, Connecticut, 1654-1704: A Structural Analysis of Economic and Political Relationships
No full textErna Green's thesis for a master of history on the history and examination of the public land system in the city of Norwalk, CT.This thesis is being archived as a Digitized Shelf Copy for campus access to current students and staff only. We currently cannot provide this open access without the author's permission. If you are the author of this work and desire to provide it open access or wish access removed please contact the Wahlstrom Library to discuss permission
14th annual John Perkins Lecture
No full textDr. John Perkins returns to campus Tuesday, April 30, 11 a.m., at First Free Methodist Church, for the 14th annual John Perkins Lecture Series. This year’s morning event features Erna Kim Hackett, executive pastor at The Way Berkeley. Later that day, Hackett and Dr. Perkins will continue the morning’s topic, “Words Have Power,” at 7:30 p.m., also in First Free Methodist Church.
John Perkins is one of the leading evangelical voices to come out of the American civil rights movement and an internationally known author, speaker, and teacher. His is the co-founder of SPU’s John Perkins Center for Reconciliation, Leadership Training, and Community Development and the author of the new book One Blood: Parting Words to the Church on Race and Love. Erna Kim Hackett served with InterVarsity for 18 years in Black Ministries and Urban Programs. She is a preacher, pastor, writer, activist, and singer
Computational analysis of active enhancers and their functions in breast cancer patients through the study of eRNA transcription
No full textM.Phil.Enhancers specify cell identity by establishing cell-type specific gene transcription programmes through the recruitment of distinct sets of transcription factors. Aberration of enhancer activity has been linked to various pathogenic conditions including cancers. While enhancers are being widely accepted as non-coding regions in the genome that positively regulate gene expression, accumulating evidences suggest them to be transcription units themselves, producing enhancer RNAs (eRNAs) through uni- or bi-directional transcription. It is dubious whether the RNA transcript or the act of transcription contributes to enhancer activity, but the robustness of eRNA production from active enhancers and the correlation between enhancer transcription and the formation of enhancer-promoter loops suggest eRNA to be a promising signature of active enhancers, on par with, if not outperforming, classic markers such as H3K27ac and a high H3K4me1/H3K4me3 ratio. Aberration of enhancer function by mutations or structural changes in enhancer regions and/or their associated factors have been shown to contribute to tumorigenesis. Recent studies have made use of different enhancer detection methods (e.g. ChIP-Seq, Bisulfite-Seq, GRO-Seq) along with transcriptome profiling to explore the roles of enhancers in cancers. However, the use of multiple techniques is costly, and some of them require a large amount of starting materials and therefore is suitable mostly for cell lines. With growing evidence that enhancers play a major role in tumorigenesis,the field thus calls for a more accessible method to detect aberrant enhancer activities in clinical cancer samples.Making use of breast cancer as an example, a bioinformatics workflow is presented in this thesis to quantify enhancer activity from clinical samples by accurately annotating and quantifying eRNA abundance from total RNA sequencing (RNA-Seq) data. Resulting gene expression change from alteration in enhancer activity could also be detected from the same RNA-Seq data, which greatly reduces sequencing cost and at the same time ensures sample consistency. Significant differential expression between tumor and normal tissue samples was observed for breast cancer-related genes. Some differentially transcribed enhancers were also found to overlap with regions of known variants related to the disease. To evaluate the effect of aberrant enhancer activity on the expression of disease-related genes, enhancer::target regulatory network was constructed using sparse optimisation models. Consistent with previous studies, low order regularisation model was found to outperform L1 regularisation model in this type of analysis.This study potentiates the detection of enhancer malfunction along with the associated deregulation of gene expression from RNA-Seq data of clinical cancer samples, providing a universal computational method for the quantification of eRNA abundance, and also for the prediction of enhancer regulatory networks involved in disease progression. These findings shed lights onto the contribution of enhancers in cancer development, and provide insights into the use of eRNAs or enhancers in the development of cancer diagnosis and therapeutic strategies.透過招募不同的轉錄因子，增強子在不同類型的細胞中建立細胞特異性的基因轉錄程序，從而指定細胞的身份。異常的增強子活動跟癌症以及多種病症有著莫大的關係。縱使增強子一向被廣泛認為是基因組中非編碼的部份，愈來愈多證據顯示增強子能夠被轉錄並通過單向或雙向轉錄產生增強子RNA （enhancer RNA，或 eRNA）。雖然eRNA轉錄本或增強子的轉錄行為是否有助其活性仍然存疑，但活性增強子產生的大量eRNA以及增強子的轉錄與增強子—啟動子環形成的相關性均意味著eRNA是增強子活性的可靠指標，甚至比傳統的標記例如H3K27ac 及高H3K4me1/H3K4me3比例更為準確。因增強子或其相關因子的基因突變或結構改變而產生之異常增強子功能曾被發現有助腫瘤的形成。最近的研究結合轉錄組以及多種增強子檢測方法（例如ChIP-Seq，Bisulfite-Seq，GRO-Seq）探討增強子在癌症中的作用。惟多種方法的結合令實驗變得昂貴，某些技術更需要大量的組織或細胞，因此只適用於細胞系的研究。隨著更多的證據顯示增強子在腫瘤形成中擔當重要的角色，我們需要更方便的方法從臨床癌症樣本中檢測異常的增強子活性。本論文以乳腺癌為例，提出了一個適用於檢視增強子活性的生物信息分析流程。流程從total RNA-Seq數據中準確註釋和量化eRNA的表達，從而量化臨床樣本中之增強子活性。增強子活性之改變而導致的基因表達變化亦能同時從相同之total RNA-Seq數據組中獲取。此舉大大減低了測序成本，亦確保了樣本之間的一致性。分析結果顯示已知與乳腺癌有關的基因之表達在腫瘤及正常組織樣本之間有顯著差異。我們亦發現部份有顯著轉錄差異的增強子與乳腺癌相關之基因組變異出現的區域吻合。為了進一步評估異常之增強子活性對疾病相關的基因表達有何影響，我們利用了稀疏優化模型構建增強子及其靶基因的調控網絡。本研究與之前的研究一致認為低階正則化模型在這類分析中的表現比L1正則化模型表現更為理想。本研究使從臨床腫瘤樣本的RNA-Seq數據中同時檢測異常增強子功能及因此而失調之基因表達變得可能，且提供了可通用於各類型細胞的計算方法來量化eRNA及預測與疾病發展有關的增強子調控網絡。我們的研究揭示了增強子在癌症發展中的作用，並為發展eRNA或增強子作為癌症診斷及治療策略方面提供了新的見解。Cheung, Ka Man Fiona.Thesis M.Phil. Chinese University of Hong Kong 2018.Includes bibliographical references (leaves 93-110).Abstracts also in Chinese.Title from PDF title page (viewed on …)
Contextualizing narrative theory: reading the politics of formal innovation in contemporary women's fiction
No full textTo ignore the strategies and structures through which stories are told, this thesis contends, is to neglect a vital dimension of their politics. Narratology provides productive analytical tools to illuminate the complex and varied mechanics of narrative form, yet it also bears the traces of its structuralist origins. Its value is therefore contingent upon its continuing reformulation as an expansive, pluralist and contextualized critical discipline. Participating in this expansion, this
thesis evidences the pertinence and vitality of some narratological models and the limitations of others. It opens up alternative critical possibilities by drawing upon insights within contemporary critical theory, from poststructuralist philosophy to transcultural feminism to
sociolinguistics. Above all, my interventions proceed from close readings of innovative fiction by women writers hitherto all but unrepresented in, and therefore potentially subversive of, existing models: Nicole Brossard, Daphne Marlatt, Hiromi Goto, Ali Smith, Jackie Kay, Erna Brodber, Dionne Brand, Aritha van Herk.
The first chapter formulates an in-between critical space where feminist and postmodernist theories of narrative intersect. It re-examines metafiction through the lens of auto(bio)graphical practice and feminist poststructuralist theories of self, and introduces the notions of folds and
echoes to describe specific structural innovations. Chapter Two examines unconventional uses of second-person address and reconsiders existing narratological approaches in their light, focusing on the `push and pull of narrative' that the `you' form enacts. Chapter Three addresses the insufficient attention paid to multiply narrated novels, theorizing them as `narrative communities' and introducing terms to describe different internal relations between narrators, relations that can often be read as determinedly 'democratic'. The final chapter contests the
hegemony of temporal models of narrativity by formulating a 'spatial poetics' that accounts both for how spatial structures can be agents of narrative change and for the complexity of textual constructions of space, which frequently exceed static definitions of 'setting'.
Running throughout is a reconception of narrative as located not with the figure of the narrator, but in relations of intersubjectivity. The narratological criticism formulated here works towards a situated ethics of reading responsive to the politics of writing: it is engaged, relational, and ever in process
On the weight spaces of Lie algebra modules and their Jordan kernel
No full textLet L be a finite-dimensional Lie algebra over a field k of characteristic zero and let V be an L module. If S is a subset of L and i a function from S to k, we define the eigenspace V,(S) and the weight space V'(S) of V with respect to ;1 (and S) by vj,(s)= {UE V~vxES,XU=l"(x)u}, v"(S)= {VE VIvxES,3nEN, [x-A(x)]"u=O). Particularly, if S has only one element, we use the notations V,+,(s) and V"'"'(s) instead of V,({s}) and vi-({s}) and, if S coincides with L, we write V1 and V" instead of V,(L) and V'(L). If V'(S) is nonzero, we call 1 a weight of S in V. Remark that, if V is finite-dimensional, V'(S) is the set of all u E V such that [x-n(x)]" v = 0 for all x E L, where n is the dimension of V. It is clear that V, is a submodule of V, contained in V". Moreover, if V, is nonzero, then I must be a character of L (i.e., A is linear and ;1([L, L]) = 0). In [8] Smith asks wether Vi must be nonzero, if V" is non-zero. In case V is finite-dimensional, she answers this question affirmatively in [9] and she also proves that, in that situation, V" is a submodule of I'. These results may be generalized to arbitrary L modules V [Theorem 31. We are able to give a new characterization of these weight spaces [Theorem 11, Proposition 131 which greatly simplifies their actual computation. We also take special interest in applying these results to the case where V is either the universal enveloping algebra U(L) of L or its division ring of quotients D(L). In the latter case, each weight vector of D(L) can be written as a quotient of a weight vector of U(L) by a nonzero eigenvec-tor (semi-invariant) of U(L) [Proposition 173. Furthermore, we define the 28We would like to express our gratitude to A. Joseph, R. Rentschler, and P. Tauvel for giving some helpful suggestions and for inviting the first author to hold a talk on the subject at the “Seminaire sur les Algtbres Enveloppantes” at the University of Paris. In particular, we would like to thank R. Rentschler for pointing out to us Propositions 2 and 1
Rhythmicity and Broken Narrative as a Means of Portraying Identity Crisis in Erna Brodber’s Jane and Louisa Will Soon Come Home
No full textIn the present thesis, Jane and Louisa Will Soon Come Home, the novel by the Jamaican writer Erna Brodber, is analyzed in the context of post-colonial identity trauma. Analyzing the complex organizational and narrative structure of the novel, the essay author studies how the novel’s rhythmicity and the broken narrative portray the protagonist’s identity fragmentation. Drawing on the work’s connection to the ring game played in the Caribbean and applying the symbolism of the Caribbean folk rhythms, the essay author discusses the subversive intent of Brodber’s novel and her method of rewriting the past as a way of recovering one's identity.
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