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Mechanisms for the maintenance and eventual degradation of neurofilament proteins in the distal segments of severed goldfish Mauthner axons
No full textCellular mechanisms that might affect the degradation of neurofilament proteins (NFPs) were examined in the distal segments
of severed goldfish Mauthner axons (M-axons), which do
not degenerate for more than 2 months after severance. Calpain
levels, as determined by reactivity to a polyclonal antibody,
remained constant for 80 d postseverance in distal segments
of M-axons and then declined from 80 to 85 d
postseverance. Calpain activity in rat brain, as determined by a
spectrophotometric assay, was much higher than calpain activity
in control and severed goldfish brain, spinal cord, muscle,
or M-axons. Calpain activity was extremely low in M-axons
compared with that in all other tissues and remained low for up
to 80 d postseverance in distal segments of M-axons. Phosphorylated
NFPs, as determined by Stains-All treatment of SDS
gels, were maintained for up to 72 d postseverance and then decreased noticeably at 75 d postseverance when NFP breakdown
products appeared on silver-stained gels. By 85 d postseverance,
phosphorylated NFPs no longer were detected, and
NFP breakdown products were the most prominent bands on
silver-stained gels. These results suggest that the distal segments
of M-axons survive for months after severance, because
NFPs are maintained in a phosphorylated state that stabilizes
and protects NFPs from degradation by low levels of calpain
activity in the M-axon; the distal segments of severed M-axons
degenerate eventually when NFPs no longer are maintained in
a phosphorylated state and become susceptible to degradation,
possibly by low levels of calpain activity in the M-axon.This work was supported by an Advanced Technology Project Grant to G.D.B.Neuroscienc
MS002: Julia Bertner, Hugh Roy Cullen, and Others at A Ceremony for The M. D. Anderson Hospital for Cancer Research
No full textJulia Bertner, Hugh Roy Cullen, and others at a ceremony for the M. D. Anderson Hospital for Cancer Research. See more at Ernst William Bertner, MD Papers and its finding aid.https://digitalcommons.library.tmc.edu/exhibit_construction/1169/thumbnail.jp
The Semigeostrophic Equations Discretized in Reference and Dual Variables
No full textWe study the evolution of a system of n particles in a 2d-dimensional euclidean space. That system is a conservative system with a Hamiltonian of the form H(h)=W(h,kn), where W is the Wasserstein distance and m is a discrete measure. Typically, ho is a discrete measure approximating an initial essentially bounded density and can be chosen randomly. When d=1, our results prove convergence of the discrete system to a variant of the semigeostrophic equations. We obtain that the limiting densities are absolutely continuous with respect to Lebesgue measure. When kn converges to a measure concentrated on a special d-dimensional sets, we obtain the Vlasov-Monge-Ampère (VMA) system. When d=1, the VMA system coincides with the standard Vlasov-Poisson system
1ST MEASUREMENT OF GAMMA(D(S)(+)-]MU+NU)/GAMMA(D(S)(+)-]PHI-PI+)
No full textComplete Author List:
ACOSTA D, ATHANAS M, MASEK G, PAAR H, BEAN A, GRONBERG J, KUTSCHKE R, MENARY S, MORRISON RJ, NAKANISHI S, NELSON HN, NELSON TK, RICHMAN JD, RYD A, TAJIMA H, SCHMIDT D, SPERKA D, WITHERELL MS, PROCARIO M, YANG S, BALEST R, CHO K, DAOUDI M, FORD WT, JOHNSON DR, LINGEL K, LOHNER M, RANKIN P, SMITH JG, ALEXANDER JP, BEBEK C, BERKELMAN K, BESSON D, BROWDER TE, CASSEL DG, CHO HA, COFFMAN DM, DRELL PS, EHRLICH R, GALIK RS, GARCIASCIVERES M, GEISER B, GITTELMAN B, GRAY SW, HARTILL DL, HELTSLEY BK, JONES CD, JONES SL, KANDASWAMY J, KATAYAMA N, KIM PC, KREINICK DL, LUDWIG GS, MASUI J, MEVISSEN J, MISTRY NB, NG CR, NORDBERG E, OGG M, PATTERSON JR, PETERSON D, RILEY D, SALMAN S, SAPPER M, WORDEN H, WURTHWEIN F, AVERY P, FREYBERGER A, RODRIGUEZ J, STEPHENS R, YELTON J, CINABRO D, HENDERSON S, KINOSHITA K, LIU T, SAULNIER M, SHEN F, WILSON R, YAMAMOTO H, ONG B, SELEN M, SADOFF AJ, AMMAR R, BALL S, BARINGER P, COPPAGE D, COPTY N, DAVIS R, HANCOCK N, KELLY M, KWAK N, LAM H, KUBOTA Y, LATTERY M, NELSON JK, PATTON S, PERTICONE D, POLING R, SAVINOV V, SCHRENK S, WANG R, ALAM MS, KIM IJ, NEMATI B, ONEILL JJ, SEVERINI H, SUN CR, ZOELLER MM, CRAWFORD G, DAUBENMIER CM, FULTON R, FUJINO D, GAN KK, HONSCHEID K, KAGAN H, KASS R, LEE J, MALCHOW R, MORROW F, SKOVPEN Y, SUNG M, WHITE C, WHITMORE J, WILSON P, BUTLER F, FU X, KALBFLEISCH G, LAMBRECHT M, ROSS WR, SKUBIC P, SNOW J, WANG PL, WOOD M, BORTOLETTO D, BROWN DN, FAST J, MCILWAIN RL, MIAO T, MILLER DH, MODESITT M, SCHAFFNER SF, SHIBATA EI, SHIPSEY IPJ, WANG PN, BATTLE M, ERNST J, KROHA H, ROBERTS S, SPARKS K, THORNDIKE EH, WANG CH, DOMINICK J, SANGHERA S, SHELKOV V, SKWARNICKI T, STROYNOWSKI R, VOLOBOUEV I, ZADOROZHNY P, ARTUSO M, HE D, GOLDBERG M, HORWITZ N, KENNETT R, MONETI GC, MUHEIM F, MUKHIN Y, PLAYFER S, ROZEN Y, STONE S, THULASIDAS M, VASSEUR G, ZHU G, BARTELT J, CSORNA SE, EGYED Z, JAIN V, SHELDON P, AKERIB DS, BARISH B, CHADHA M, CHAN S, COWEN DF, EIGEN G, MILLER JS, OGRADY C, URHEIM J, WEINSTEIN A
Hypoxic potentiation of nitrite effects in human vessels and platelets
No full textAbstract not availableRustem F. Dautov, Irene Stafford, Saifei Liu, Hugh Cullen, M. Madhani, Yuliy Y. Chirkov, John D. Horowit
Linear polarization measurement of interband transitions in superdeformed (190)Hg: model-independent evidence for octupole vibrational structures
No full textThe linear polarization of γ rays between excited and yrast superdeformed (SD) states in 190Hg was measured using the four-element CLOVER detectors of the EUROBALL IV γ-ray spectrometer. This measurement shows in a model-independent way that the interband transitions which compete with the highly collective in-band quadrupole transitions are largely enhanced electric dipoles. Not only do these results represent the first measurement of the multipolarity of transitions between different SD states, but they also provide strong evidence for the interpretation of the structures in the SD minimum of the A∼190 region in terms of octupole excitations.A. Korichi, A. N. Wilson, F. Hannachi, A. Lopez-Martens, M. Rejmund, C. Schück, Ch. Vieu, G. Chmel, A. Görgen, H. Hübel, D. Rossbach, S. Schönwasser, M. Bergström, B. M. Nyakó, J. Timár, D. Bazzacco, S. Lunardi, C. Rossi-Alvarez, P. Bednarczyk, N. Kintz, S. Naguleswaran, A. Astier, D. M. Cullen, J. F. Sharpey-Schafer, T. Lauritsen, and R. Wadswort
Collective excitations in the superdeformed well
No full textCollective excitations are commonplace features in nuclei at normal deformation. It has been suggested that both in the A\sim 190 and 150 superdeformed (SD) nuclei, collective vibrational states might occur in the same excitation energy range as quasi-particle and single-particle excitations. In particular, the large deformation associated with SD nuclei brings together orbitals from many spherical shells and leads to the close proximity of states with opposite parity, favouring octupole shape vibrations. However, to date, \sim 200 SD bands have been reported in more than 50 nuclei and in most cases, the excited SD bands have been interpreted as single or quasi-particle excitations. Only in very few cases, has the collective excitation scenario been suggested. Where are the collective states in SD nuclei? The question is particularly relevant in even--even A=190 nuclei in which SD states are observed at lower rotational frequency and hence the additional influence of the pair gap makes the collective excitations more competitive with quasi-particle excitations.F. Hannachi, A. Korichi, A.N. Wilson, A. Lopez-Martens, M. Rejmund, C. Schueck, Ch. Vieu, G. Chmel, A. Goergen, H. Huebel, D. Rossbach, S. Schoenwasser, M. Bergstroem, B.M. Nyako, J. Timar, D. Bazzacco, S. Lunardi, C. Rossi-Alvarez, P. Bednarczyk, N. Kintz, S. Naguleswaran, A. Astier, D.M. Cullen, J.F. Sharpey-Schafer, T. Lauritsen, R. Wadsworthhttp://th-www.if.uj.edu.pl/acta/vol32/abs/v32p1083.ht
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
No full textMutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of CTSD deficiencies. To identify the early events that lead to synaptic alterations, we investigated synaptic ultrastructure and function in presymptomatic CTSD knockout (Ctsd) mice. Electron microscopy revealed that there were significantly greater numbers of readily releasable synaptic vesicles present in Ctsd mice than in wild-type control mice as early as postnatal day 16. The size of this synaptic vesicle pool continued to increase with disease progression in the hippocampus and thalamus of the Ctsd mice. Electrophysiology revealed a markedly decreased frequency of miniature excitatory postsynaptic currents (mEPSCs) with no effect on paired-pulse modulation of the evoked excitatory post synaptic potentials in the hippocampus of Ctsd mice. The reduced mEPSCs frequency was observed before the appearance of epilepsy or any morphologic sign of synaptic degeneration. Taken together, these data indicate that CTSD is required for normal synaptic function and that a failure in synaptic trafficking or recycling may bean early and important pathologic mechanism in Ctsd mice; these presynaptic abnormalities may initiate synaptic degeneration in advance of subsequent neuronal loss
Syndepositional Tectonics and mass-transport deposits control channelized, bathymetrically complex deep-water systems (AíNSA depocenter, Spain)
No full textA 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
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