Journals published by Medical University of Lublin
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Is childhood interstitial lung disease (chILD) still a mystery in infants?
No full textChildhood interstitial lung disease (chILD) comprises a heterogeneous group of several hundred disorders that affect not only the pulmonary interstitium, as suggested by the name, but also other components of the respiratory system. The prevalence of chILD remains unclear and depends largely on the data source. Many patients die before a definitive diagnosis is established, which further complicates the estimation of disease incidence in infants.In recent years, increased recognition of chILD has drawn growing attention within the medical community. As a result, these disorders have been classified into two major groups: those presenting in children younger than 2 years of age and those affecting older children. Nevertheless, the diagnostic process remains highly challenging. These diseases are rare, and their onset during the neonatal period is often associated with high mortality before a comprehensive diagnostic evaluation can be completed.Currently, several therapeutic options for chILD are available; however, none ensures consistent treatment success. Ongoing research is exploring novel therapeutic strategies, including stem cell transplantation, which may offer new hope for improving outcomes and survival in patients with chILD in the future
Patient rights and self-assessment of their application by physicians employed in public healthcare facilities
Get PDFAim. Patient rights are a set of rights granted to healthcare recipients. They include objective standards which inform patients about what they can expect from public authorities and institutions directly providing healthcare services. The main objective of the study was to assess the knowledge of physicians employed in public healthcare facilities about patient rights.
Material and methods. The study was conducted in the period between October 2022 and March 2023. The diagnostic survey method was employed, using a self-developed questionnaire. One hundred respondents employed in hospitals and primary health-care facilities took part in the study. Microsoft Excel (Microsoft Office) was used to compile the data. The statistical analysis was conducted with the use of the Statistica 13.1 PL statistical software.
Results. 61% of physicians reported their knowledge of patient rights to be satisfactory, while 39% found it unsatisfactory. 33% of respondents were familiarized with patient rights in the course of their higher education, while 67% learned about them only in the workplace. Meanwhile, 51% of respondents were familiar with the Patient Rights and the Patient Rights Ombudsman Act. 79% indicated that they complied with patient rights in their professional practice, while 33% of respondents confirmed that they had witnessed violations of patient rights in their workplace.
Conclusions. Based on research, it can be concluded that there is a need to develop and implement a training program for medical personnel on patients’ rights. Doctors’ lack of knowledge about patients’ rights influences the exercise or violation of these rights
Aquatic Biodiversity and Mental Health: Lack of Association Evidence from Empirical Studies and Global Research Trends
Get PDFIntroduction: Aquatic biodiversity plays a crucial role in maintaining ecological balance, supporting ecosystem services, and enhancing human well-being. This study aimed to assess global research trends and empirical evidence on the relationship between aquatic biodiversity and mental health outcomes, while identifying thematic gaps and emerging areas of inquiry.
Materials and methods: A bibliometric analysis was conducted using the Web of Science Core Collection (2014–2025) and analysed in R with Bibliometrix (Biblioshiny). From an initial 19,320 records, 159 highly cited original research articles were screened using the Rayyan systematic review platform, resulting in 10 eligible studies that directly examined human mental health in relation to aquatic biodiversity or blue space quality.
Results: The study results show that research at this intersection remains limited, with mental health often treated as a secondary or indirect aspect within broader ecological or sustainability frameworks. Emerging but underexplored topics include emotional exhaustion, depression, and stress linked to the degradation of aquatic ecosystem and water insecurity. Content analysis of the 10 studies revealed no direct quantitative evidence linking measured aquatic biodiversity to mental health outcomes. Instead, perceived environmental quality and visible wildlife presence consistently predicted higher wellbeing and more frequent engagement with aquatic environments, suggesting that perceived biodiversity may serve as a key intermediary for psychological benefits.
Conclusions: These findings underscore the need for longitudinal, interdisciplinary research that integrates ecological metrics with psychological assessments. Strengthening collaboration among environmental scientists, psychologists, and public health experts will be essential to establishing an evidence-based frameworks linking aquatic biodiversity with mental health. Wstęp: Różnorodność biologiczna środowiska wodnego odgrywa kluczową rolę w utrzymaniu równowagi ekologicznej, wspieraniu usług ekosystemowych i poprawie jakości życia ludzi. Celem niniejszego badania była ocena globalnych trendów badawczych i dowodów empirycznych dotyczących związku między różnorodnością biologiczną środowiska wodnego a zdrowiem psychicznym, a także identyfikacja luk tematycznych i nowych obszarów badań.
Materiał: Przeprowadzono analizę bibliometryczną przy użyciu bazy danych Web of Science Core Collection (2014–2025) i przeanalizowano ją w programie R z wykorzystaniem Bibliometrix (Biblioshiny). Spośród początkowych 19 320 rekordów, przy
użyciu platformy do przeglądu systematycznego Rayyan, wybrano 159 często cytowanych oryginalnych artykułów naukowych, co dało 10 kwalifikujących się badań, które bezpośrednio dotyczyły zdrowia psychicznego człowieka w odniesieniu do różnorodności biologicznej środowiska wodnego lub jakości przestrzeni wodnej.
Dyskusja: Wyniki wskazują, że badania w tym obszarze są nadal ograniczone, a zdrowie psychiczne często traktowane jest jako kwestia drugorzędna w kontekście ekologii i zrównoważonego rozwoju. Niewystarczająco zbadane pozostają tematy takie jak wyczerpanie emocjonalne, depresja i stres wynikające z degradacji ekosystemów wodnych i braku bezpieczeństwa wodnego. Analiza 10 badań nie potwierdziła bezpośredniego związku ilościowego między zmierzoną różnorodnością biologiczną a zdrowiem psychicznym. Jednak postrzegana jakość środowiska i obecność dzikiej przyrody konsekwentnie wiązały się z wyższym dobrostanem, co sugeruje, że subiektywnie odbierana różnorodność biologiczna może pośredniczyć w korzyściach psychologicznych.
Wnioski: Wyniki te podkreślają potrzebę przeprowadzenia długoterminowych, interdyscyplinarnych badań, które integrują wskaźniki ekologiczne z ocenami psychologicznymi. Wzmocnienie współpracy między naukowcami zajmującymi się ochroną środowiska, psychologami i ekspertami ds. zdrowia publicznego będzie miało zasadnicze znaczenie dla ustanowienia opartych na dowodach ram łączących różnorodność biologiczną środowiska wodnego ze zdrowiem psychicznym.
Effect of broiler chicken egg white gel extract (Gallus domesticus) on wound healing durationin male Mus musculus mice
No full textSkin injuries that disrupt soft tissue integrity result in wounds. Wound healing is a complex and prolonged process involving tissue repair and remodeling in response to injury. When skin continuity is lost, its protective and regulatory functions are compromised. Therefore, appropriate wound management and treatment are essential to prevent infection and the development of chronic wounds.This study aimed to compare wound healing duration following incision wounds treated with broiler chicken egg white gel extract. A quasi-experimental study with a post-test control group design was conducted. Two treatment groups were included. In Group I, wounds were cleansed with 0.9% sodium chloride (NaCl) solution, while in Group II, wounds were treated with a broiler chicken egg white gel extract ointment.The results demonstrated a significant difference in wound healing duration between the two groups. Treatment with broiler chicken egg white gel extract (Gallus domesticus) ointment accelerated wound healing more effectively than the control treatment using 0.9% NaCl
Effects of curcumin and its derivatives on a glioma cell line
No full textGlioblastomas are highly invasive brain tumors associated with oxidative stress (OS) and chronic inflammation. Curcumin (CUR), the principal bioactive compound of Curcuma longa, as well as its natural analogues demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), exhibit promising therapeutic properties.
The aim of this study was to evaluate the antioxidant effects of CUR, DMC, and BDMC in an in vitro model using the LN229 glioma cell line.LN229 glioblastoma cells and MO3.13 cells as a non-tumor control were cultured in Dulbecco’s Modified Eagle Medium (DMEM) under standard conditions. Cells were treated with CUR, DMC, and BDMC for 24 h and 48 h at concentrations selected based on MTT assay results. Antioxidant capacity was assessed using the ferric reducing antioxidant power (FRAP) assay, while lipid peroxidation and protein oxidation were evaluated by measuring malondialdehyde (MDA) and protein carbonyl group levels, respectively, in cell lysates.Curcumin, demethoxycurcumin, and bisdemethoxycurcumin reduced LN229 cell viability in a time- and dose-dependent manner. Curcumin exhibited the strongest antioxidant activity, significantly decreasing MDA levels and protein carbonyl content (p < 0.001). Demethoxycurcumin was the most effective compound in reducing protein oxidation after 48 h, whereas bisdemethoxycurcumin increased MDA levels, suggesting a potential pro-oxidative effect. The FRAP assay confirmed a sustained antioxidant capacity of all compounds, particularly at higher concentrations.In conclusion, curcumin and its derivatives demonstrated both antioxidant and cytotoxic activities in a time- and dose-dependent manner. Among the tested compounds, curcumin showed the most stable and long-lasting antioxidant and cytotoxic effects, indicating its potential therapeutic value in mitigating oxidative stress–related damage in glioma cells
ABO blood types as a risk factor for severe symptoms of COVID-19 infection
No full textNumerous studies have investigated whether the ABO blood group system influences susceptibility to SARS-CoV-2 infection and disease severity. The association between blood type and COVID-19 is thought to involve both genetic and environmental factors. The present study aimed to evaluate the relationship between ABO blood phenotypes and the severity of COVID-19 among Arab populations, with a particular focus on Iraqi patients.To assess the association between ABO blood phenotypes and the occurrence and severity of SARS-CoV-2 infection.A total of 731 patients with COVID-19 confirmed by a positive PCR test were included in the study. A control group consisted of healthy volunteers with negative PCR results and no clinical symptoms of COVID-19. In all participants, ABO blood phenotype was determined. In infected patients, disease severity and mortality were evaluated and analyzed in relation to blood group phenotype.Patients with blood group A demonstrated a higher risk of COVID-19 infection compared with non-A blood groups. In contrast, individuals with blood group O showed a significantly lower incidence of COVID-19 infection and reduced disease severity (odds ratio [OR] = 0.686; 95% confidence interval [CI]: 0.521-0.902). No statistically significant differences were observed for other blood groups. Among critically ill patients, blood group A was associated with a significantly higher mortality rate compared with non-A blood groups (OR = 3.341; 95% CI: 1.416-8.158).Blood group A is associated with an increased risk of severe COVID-19 manifestations, including pneumonia and mortality, whereas blood group O appears to confer a protective effect against severe disease
Gastroprotective effect of an Algerian hydroalcoholic Punica granatum L. peel extract against ethanol/HCl-induced gastric mucosal injury in Wistar rats
No full textUlceration represents a significant pathological condition, and research into effective treatment is imperative. The present study sought to evaluate the gastroprotective effect of pomegranate hydroalcoholic peel extract (PGPE) on an ulcer model induced by acidified ethanol (HCl/ethanol) in Wistar rats. The experimental animals were divided into six groups. Group 1 was a negative control that was treated with distilled water. Group two was utilized as the positive control, receiving a treatment of acidified ethanol (20/80; v/v) with the objective of inducing ulceration. Groups three to six were administered 0.75, 1.50, and 3.0 g/kg of PGPE, along with 0.10 g/kg of omeprazole, which served as the reference pharmaceutical agent. Rats were administered acidified ethanol via oral gavage one hour later. A substantial increase in pH and an increase in gastric mucus were observed, accompanied by a decrease in gastric mucosal damage, in animals fed with PGPE. The histopathological results indicated significant destruction of the gastric mucosa in the ulcer control group. However, gastroprotective effects were observed in rats pretreated with plant extract. Current research suggests that PGPE has potential antiulcer effects, possibly through its high antioxidant activity, possibly due to its bioactive constituents. The results obtained from this study offer valuable insights into the nutritional composition of the products under scrutiny. It is recommended that further preclinical and clinical trials be conducted to evaluate the natural active agents and effectiveness of this plant
Current trends and prospects for the development of sports nutrition worldwide and in Ukraine
No full textSports nutrition (SN) represents a dynamically developing segment of the global food and dietary supplement market, driven by increasing interest in physical activity and healthy lifestyles.The study aimed to analyze current trends in the development of the sports nutrition market worldwide and in Ukraine, using the AthleteMarket retail network as a case study.The research was based on a review of specialized scientific literature, market reports, and an analysis of the product assortment offered by the AthleteMarket online store in 2021. Systemic, comparative, statistical, and graphical methods were applied.The global sports nutrition market demonstrates steady growth, with an average annual growth rate estimated at 8.1-11.0% and a projected value of up to USD 90 billion. The Ukrainian sports nutrition market is characterized by a high level of import dependence, with foreign manufacturers accounting for approximately 90.0% of available products. Analysis of the AthleteMarket assortment revealed the predominance of protein-based products and fat burners, with solid dosage forms (powders, capsules, tablets) representing 96.0% of the total range. Flavor variety remains an important factor for consumers, with vanilla, chocolate, and strawberry being the most common options. The AthleteMarket franchise model presents opportunities for business expansion within Ukraine.The sports nutrition market continues to expand globally and nationally, creating favorable conditions for further development. In Ukraine, market growth offers potential opportunities for domestic manufacturers and franchise-based retail expansion; however, further research and regulatory support are required to promote the rational use of sports nutrition products
Synthesis, characterization, and antibacterial properties of selected glucose derivatives
No full textA multistep synthetic route was developed for the preparation of a diazido compound starting from methyl α-D-glucopyranoside 1. The synthesis began with protection of the C-4 and C-6 hydroxyl groups using a benzylidene protecting group. Compound 2 was subsequently reacted under phase-transfer conditions with bis (2-chloroethyl) ether to afford the bis-chloro derivative 3. Compound 3 was then converted into a more effective leaving-group derivative, namely the iodide compound 4 . Finally, nucleophilic substitution of the iodide groups with azide ions was carried out by reacting compound 4 with sodium azide in dimethylformamide, yielding the target diazido derivative 5.In addition, the synthesized compounds were evaluated for antibacterial activity against Escherichia coli and Staphylococcus aureus using the agar well diffusion method. The results demonstrated moderate antibacterial activity against both tested strains. Structural characterization of all synthesized compounds was performed using infrared (IR) spectroscopy and nuclear magnetic resonance spectroscopy (1H NMR and 13C NMR)
Molecular docking studies of various bioactive molecules from Withania somnifera against bronchial asthma
No full textAsthma is a complex respiratory disorder characterized by chronic inflammation and hyperresponsiveness of the bronchial airways. Despite the availability of effective treatments and diagnostic methods, some patients remain symptomatic and exhibit a poor response to conventional asthma therapies. Herbal drugs are considered safe and effective alternative approaches that may target multiple pathogenic pathways involved in asthma. Withania somnifera (WS) is a well-known medicinal plant containing several bioactive compounds and has been extensively studied for its anti-inflammatory and immunomodulatory properties.The present study aimed to explore the potential mechanisms of WS bioactive molecules in the treatment of asthma using an in silico screening approach.Six active phytoconstituents (ligands) of WS were docked against two target receptor proteins, namely the glucocorticoid receptor and the β₂-adrenergic receptor, to predict binding energies and binding patterns. The obtained results were compared with those of known ligands of the glucocorticoid and β₂-adrenergic receptors (fluticasone and salbutamol, respectively).Among all docked ligands, withaferin A, withanolide D, and withanolide B exhibited the highest binding affinities (lowest estimated free binding energy of -8.4 kcal/mol) toward the glucocorticoid receptor (GR). In contrast, the WS alkaloids tropine and anaferine showed lower affinities, as evidenced by higher binding energy values. Furthermore, withanolide D and withanolide B demonstrated the highest affinity for the β₂-adrenergic receptor among the screened compounds, whereas salbutamol and the plant alkaloids tropine and anaferine exhibited lower affinity toward the β₂-adrenergic receptor compared with the plant withanolides.WS bioactive compounds, particularly withanolides, are predicted to possess multitarget anti-inflammatory and bronchodilator potential. Further experimental validation is warranted