Texas Journal of Medical Science
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Cytokine Regulation In Pubertal Girls With Opsomenorrhea Across Different Body Mass Index Categories
No full textMenstrual rhythm disturbances during puberty often reflect a combination of neuroendocrine immaturity and early forms of ovulatory dysfunction. In the context of abnormal body weight, inflammatory mechanisms may serve as an additional factor modulating reproductive regulatio
Brain Neuroplasticity in Students Under Conditions of Intensive Learning: Molecular and Cellular Mechanisms
Get PDFThe objective of the present study is to systematize current knowledge regarding the specific molecular, cellular, and systemic mechanisms of neuroplasticity activated in the brains of students during periods of intensive learning, as well as to identify the endogenous and exogenous factors that modulate the efficacy of these processe
The Influence Of Climatic And Geographical Factors On The Development Of Arterial Hypertension In The Fergana Valley
No full textArterial hypertension (HTN) remains one of the leading causes of cardiovascular disease worldwide. Climatic and geographical conditions influence the course of the disease, exacerbating or mitigating its clinical manifestations. In the Fergana Valley (continental climate, hot, dry summers, and moderately cold winters), the prevalence and severity of hypertension may vary depending on temperature and environmental factors. This study aims to examine the relationship between climatic and geographical conditions and hypertension in the adult population of the regio
Aspects Of Regional-Specific Characterization Of The Epidemiology And Risk Of Major Non-Communicable Diseases In The Adult Rural Population Of Andizhan
No full textMajor chronic non-communicable diseases (cardiovascular diseases, tumors, chronic respiratory diseases) have been among the most widespread diseases in the world for the past few years, and they remain the leading object of science and practice as the main cause of the therapeutic continuum among the population. Therefore, in the current era, preventive and prophylactic medicine, both theoretically and practically, and primarily in relation to major non-communicable diseases, has become an urgent issue and a necessity. According to the World Health Organization, "the annual mortality rate from them is 71%, and economic losses are about 1 trillion per year..." In the world, special attention is paid to epidemiological scientific research aimed at identifying the regional characteristics of the occurrence of major non-communicable diseases and creating and improving measures for the prevention of their various forms. In particular, the introduction of methods for early detection and prediction of the risk of developing major non-communicable diseases based on “…epidemiological markers” - risk factors, in populations with different characteristics is identified as one of the important tasks. At the same time, scientific research is also actively underway, including in Uzbekistan, to accurately and objectively assess the epidemiological and clinical processes in non-communicable diseases, to improve predictive algorithms - models, taking into account the territorial course of diseases and the “accumulation of risk factors”. However, despite the great achievements of medical science, there is no generally accepted methodology for the prevention of major non-communicable diseases. Western medicine believes that the outcome of prevention (population health) is 50% related to living conditions and lifestyle, 20% to environmental conditions, 20% to genetic factors, and 10% to the healthcare system. Eastern medicine believes that the outcome of prevention is 70% related to thinking, 20% to lifestyle, and 10% to nutrition
Impact Of Hypothyroidism During Pregnancy On Children's Neurodevolution (Including Autism Spectrum Disorders)
No full textThis article provides an in-depth analysis of the impact of hypothyroidism during pregnancy on child neurodevelopment, particularly autism spectrum disorders (ASD). The effects of thyroid hormone deficiency Considering the epidemiological, mechanistic and clinical aspects, maternal thyroid dysfunction has a cumulative negative impact on fetal brain development. Based on research, risk ratios, treatment efficacy, and environmental factors are discussed, and the need for preventive measures is emphasized. The article is based on a scientific approach, covering a wide range of evidence from animal models to clinical dat
Primary Prevention In Trauma Surgery Risk Reduction And Early Intervention Protocols
No full textTrauma surgery represents a high-risk area of clinical practice, where timely intervention and preventive strategies are essential to reduce morbidity and mortality. Primary prevention in trauma surgery focuses on implementing risk reduction measures and structured early intervention protocols to minimize the occurrence and severity of traumatic injuries. This article reviews current approaches to risk assessment, injury prevention strategies, and early surgical interventions aimed at improving patient outcomes. Key measures include preoperative risk stratification, adherence to safety protocols, rapid clinical assessment, and prompt initiation of evidence-based interventions
Topographic And Anatomical Pathways Of Tumor Dissemination In The Female Reproductive Organs
No full textThe anatomy of the female pelvis and reproductive organs constitutes a highly complex topographic– anatomical system that plays a pivotal role in understanding the clinical behavior and dissemination patterns of malignant tumors. Accurate knowledge of pelvic anatomy is of particular importance in gynecologic oncology, where surgical strategy, the extent of lymphadenectomy, identification of metastatic routes, and prognostic assessment are directly influenced by individual variations in vascular supply, lymphatic drainage, organ syntopy, and fascial and cellular compartments. Although classical anatomical descriptions of the pelvic organs are well established, contemporary evidence derived from magnetic resonance imaging, computed tomography, three-dimensional reconstruction, and lymphatic mapping has revealed substantial interindividual anatomical variability. These findings necessitate a critical reappraisal of traditional concepts regarding tumor spread, especially in cervical cancer, endometrial carcinoma, and ovarian neoplasms. The present review aims to synthesize current data on the anatomy of the female pelvis, fascial planes, cellular spaces, and lymphatic pathways, as well as to elucidate their role in the dissemination of gynecologic malignancies and their implications for surgical management
Factors Influencing The Favorability Of Patients With Renal Transfer
No full textThe article comparatively examines the factors affecting survival in patients who underwent kidney transplantation. The research results confirmed the dependence of survival and transplant loss after kidney transplantation on a number of factors. Among them, age, male sex, long-term dialysis, smoking, diabetes mellitus, chronic heart failure, arterial hypertension, and obesity significantly increase the risk. Insufficient immunosuppression, especially the low dose of tacrolimus, had a serious negative impact on the survival of the transplant. These data confirm that the early detection of high-risk patients, individual monitoring, and optimization of immunosuppressive therapy are crucial for increasing transplant survival. The obtained results confirm the need for a comprehensive approach to assessing post-transplant risk, taking into account clinical, immunological, and transplant-related factors, and not a single factor
Risk Factors Of Pulmonary Respiratory Disorder Syndrome In Newborns
No full textIn this article, the frequency and differences of risk factors for respiratory distress syndrome developing in the lungs of premature and full-term newborns were studied. As material, during the period 2017-2021, in the Department of Pediatric Pathology of the Republican Specialized Scientific and Practical Medical Center of Pediatric Anatomy, risk factors were studied according to the clinical and anamnestic analysis of the mother in cases of autopsy and detection of hyaline membrane in the lungs. The results showed that in most cases, asphyxia is a risk factor for the development of hyaline membranes in the lungs of premature infants - 74.5%, aspiration of amniotic fluid - 43.6%, and acute labor - 45.5%. As the main risk factor for the formation of hyaline membranes in the lungs of full-term newborns, the incidence of infection in the fetus during the prenatal period was 69.6%, and diabetes mellitus 59.3%. In full-term newborns, the following risk factors were identified: acute labor (43.7%), congenital heart defects (40.6%), pulmonary hypertension (34.3%)
Clinical Efficacy Of Diagnostic Laparoscopy In Abdominal Trauma
Get PDFThe article examines the clinical efficacy of diagnostic laparoscopy in abdominal trauma. Based on the analysis of 129 patients treated at the clinic of Tashkent State Medical University from 2023 to 2025, it was demonstrated that laparoscopy is the most informative minimally invasive method in cases of unclear clinical presentation. The authors developed and substantiated specific indications for this procedure, including the dynamics of pain syndrome, the presence of free fluid detected by ultrasound, and changes in hemodynamic parameters. The use of this technique allows timely identification of internal organ injuries and significantly reduces the number of unnecessary exploratory laparotomies