Digital Commons @ Southern University and A&M College
Not a member yet
607 research outputs found
Sort by
Taming Psoriatic Inflammation: Targeting The iNOS–Oxidative Stress–Necroptosis Axis For Precision Therapy
No full textNecroptosis is increasingly recognized as a central driver of psoriatic inflammation, promoting keratinocyte death and sustaining immune activation. Recent evidence shows that inducible nitric oxide synthase (iNOS) deficiency and exogenous nitric oxide (NO) supplementation ameliorate psoriasis-like dermatitis in mice by reducing oxidative stress and constraining necroptotic signaling. These findings identify iNOS-derived NO as both a mediator of reduction–oxidation (redox) imbalance and a key regulator of necroptosis, thereby advancing mechanistic insight into psoriatic pathogenesis. Importantly, they highlight the iNOS–oxidative stress–necroptosis axis as a translationally actionable therapeutic target. Modulating necroptotic cell death through NO-based interventions may restore epidermal homeostasis and improve clinical outcomes, offering new opportunities to reshape therapeutic strategies in psoriasis and related inflammatory skin disorders
Three Unsung Pioneers of the East Baton Rouge Parish Public Library System
No full textThe historical narrative of the United States is deeply marked by systemic racial discrimination, particularly against African Americans. White Americans employed race-based strategies to oppress and marginalize African Americans, denying them access to professional organizations and opportunities for socioeconomic advancement. This exclusion extended to the field of librarianship, where African Americans were barred from professional networks, reinforcing perceptions of the profession as a reflection of mainstream racial inequities. This report offers a concise analysis of three pioneering African American librarians who overcame entrenched racist practices to become the first African American information professionals within the East Baton Rouge Parish Public Library System. Their perseverance highlights the resilience required to challenge institutional barriers and achieve professional recognition
Plasma Proteomic Profiling Reveals Distinct Protein Signatures Associated With Hepatocellular Carcinoma In Chronic Hepatitis B Infection
No full textBackground Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC), yet reliable biomarkers for early detection and risk stratification remain limited. This study aimed to identify plasma proteins associated with disease progression from chronic HBV infection to HCC. Methods Plasma proteomic profiling was conducted using high-resolution LC–MS/MS on samples from healthy controls, chronic HBV carriers, patients with cirrhosis, and individuals with HBV-associated HCC. Differentially expressed proteins were identified through bioinformatics analysis, and protein–protein interaction networks were reconstructed to assess functional relevance. Results Eight proteins displayed distinct, stage-specific expression patterns along the disease continuum. ICAM1, TIMP1, and IGFBP7 were progressively upregulated, reflecting roles in inflammation, fibrosis, and tumorigenesis. In contrast, PF4V1 and GPLD1 were downregulated, suggesting loss of protective functions during disease progression. PFN1, TUBA1B, and MDH1 exhibited dynamic modulation linked to cytoskeletal remodeling, cell division, and metabolic reprogramming. Network analysis revealed their involvement in pathways critical for immune regulation, extracellular matrix remodeling, and angiogenesis. Random forest modeling further confirmed their strong discriminatory potential for disease staging. Conclusion This study identifies a panel of plasma proteins closely associated with HBV-related HCC progression. These biomarkers may facilitate early detection, improve risk stratification in HBV-infected individuals, and provide new insights into the molecular mechanisms driving liver cancer development
Possible Reconsideration to The Library of Congress Classification System’s Liberal Placements of African American Psychology and African American Social Science
No full textThe Library of Congress Classification (LCC), developed by Herbert Putnam in 1897, remains the predominant system for organizing materials in U.S. academic libraries. By integrating innovations with earlier classification systems by Charles Cutter and Melvil Dewey, the LCC divides human knowledge into 21 classes, each represented by alphabetic codes. While Psychology is classified under BF and social sciences under HQ, materials on African American Psychology and African American Social Science are primarily cataloged under Class E—History of America—specifically E185.625 and E185.86. This placement raises critical questions about the appropriateness of categorizing these subjects as historical rather than disciplinary. Given African Americans’ significant contributions to American culture, labor, and society, should African American Psychology and Social Science remain subcategories within American history, or is it time to reclassify them under their respective fields—or even create a new class? This paper examines the implications of current classification practices and explores potential alternatives for more accurate representation
2 Your Town Southern: Southern Archives (Interview)
No full textThe John B. Cade Library Archives at Southern University is dedicated to preserving the institution’s historical record, safeguarding thousands of photographs and documents as its official repository. Under the leadership of Angela Proctor, Head Archivist and Digitization Librarian, the department works to protect fragile collections from environmental risks while advancing digital access. In 2024, the university partnered with Getty Images to digitize archival photographs, expanding public accessibility and ensuring long‑term preservation through digital redundancy. Current efforts have digitized approximately 10% of the photographic collection through student‑supported projects. The Archives also maintain two significant sets of slave narratives collected under the guidance of former dean John B. Cade, offering invaluable firsthand accounts of individuals enslaved before and during the Civil War. With more than forty years of experience at Southern University, Proctor continues to guide the preservation of institutional and cultural history so future generations can study, interpret, and learn from the past
Bridging the AI Gap: A Librarian\u27s Journey Through Scite Summer Bootcamp
No full textMaletta Payne, librarian, shares insights from the Scite Summer Bootcamp, a four-session virtual program for researchers, librarians, faculty, and information professionals. The bootcamp emphasized practical, hands-on experience with research-grade tools, moving beyond theoretical discussions of AI
LOUIS Librarians Certified in Open Education Librarianship
No full textSUBR librarians Dr. Maya Banks and Ms. Maletta Payne successfully completed an eight-month certification program in Open Educational Librarianship through the Open Education Network, offered via the LOUIS Consortium. This professional development program is designed to prepare librarians to become effective leaders in open education initiatives and to serve as stewards and advocates for Open Educational Resources (OER)
Booked at Cade: Building Community Through Story, Scholarship, and Voice
No full textBooked at Cade Author Series Launches at John B. Cade Library In this article, SUBR Librarian Quiana Wright introduces the newly named Booked at Cade Author Series, an initiative designed to connect authors and readers through conversation, reflection, and community engagement. This season featured an impressive lineup of local, regional, and nationally recognized authors whose works celebrate Louisiana’s culture, explore the human experience, and showcase the power of storytelling. Highlights included Dr. Robert Livingston (Play the Game. Change the Game. Leave the Game), Barbara Ruffin-Robertson (The Memoirs of a Southern Creole Woman), Dr. Albert Samuels’ two-part Hurricane Katrina discussion, Dr. Mona Lisa Saloy (editor of Hurricanes Katrina & Rita at 20), and Dr. Sandra K. Johnson (Soft Power for the Journey: The Life of a STEM Trailblazer)
Viral Warriors: Unlocking The Immune System’s Potential With Oncolytic Viruses In Cancer Immunotherapy
No full textOncolytic viruses (OVs) represent an exciting avenue in tumor immunotherapy, harnessing the power of viruses to overcome resistance and enhance immune responses. OVs achieve this by selectively targeting and destroying tumor cells. This cell lysis releases tumor-specific antigens (TAAs), effectively creating an in situ vaccine that educates the immune system. Moreover, OVs directly trigger both innate and adaptive immunity and can be genetically engineered to secrete immune-boosting factors. Early studies have shown promising synergistic antitumor effects when OVs are combined with other cancer therapies or immunotherapies. A key advantage of OVs is their capacity to reprogram the tumor microenvironment (TME), transforming immunologically inert “cold” tumors into actively inflamed “hot” tumors. This environmental shift is crucial for successful immunotherapy, as it allows for increased infiltration of immune cells, particularly cytotoxic T lymphocytes (CTLs), into the tumor. This comprehensive review covers the history, mechanisms, and potential combinatorial strategies involving OVs. It also addresses the challenges faced in their development and highlights current clinical trials exploring their role as potent immunotherapeutic agents
A 14 Year Old\u27s Fight with Dementia and Alzheimer\u27s
No full textA 14 Year Old\u27s Fight with Dementia and Alzheimer\u27s, is a powerful, emotional journey through advocacy, creativity, and the power of social media to raise awareness and connect generations