IEU GCRIS Database (İzmir Ekonomi Üniversitesi)
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Cross-Cultural Data on Romantic Love and Mate Preferences From 117,293 Participants Across 175 Countries
No full textPsychological studies on close relationships have often overlooked cultural diversity, dynamic processes, and potentially universal principles that shape intimate partnerships. To address the limited generalizability of previous research and advance our understanding of romantic love experiences, mate preferences, and physical attractiveness, we conducted a large-scale cross-cultural survey study on these topics. A total of 404 researchers collected data in 45 languages from April to August 2021, involving 117,293 participants from 175 countries. Aside from standard demographic questions, the survey included valuable information on variables relevant to romantic relationships: intimate, passionate, and committed love within romantic relationships, physical-attractiveness enhancing behaviors, gender equality endorsement, collectivistic attitudes, personal history of pathogenic diseases, relationship quality, jealousy, personal involvement in sexual and/or emotional infidelity, relational mobility, mate preferences, and acceptance of sugar relationships. The resulting dataset provides a rich resource for investigating patterns within, and associations across, a broad range of variables relevant to romantic relationships, with extensive opportunities to analyze individual experiences worldwide. © The Author(s) 2025.Stanislava Stoyanova; Fundacja na rzecz Nauki Polskiej, FNP; Vira Hrabchuk and Anne MacFarlane; Narodowe Centrum Nauki, NCN, (2019/33/N/HS6/00054); Narodowe Centrum Nauki, NCN; Eesti Teadusagentuur, ETAg, (PRG2190); Eesti Teadusagentuur, ETA
PSMB8 as a Novel Target for AML Therapy: Uncovering Synergistic Potential with PI3K Inhibitors
No full textAkut miyeloid lösemi (AML), progenitör kan hücrelerindeki genetik mutasyonlar nedeniyle hematopoetik kök hücrelerde meydana gelen düzensizliklerden kaynaklanan bir kemik iliği hastalığıdır. Bu mutasyonlar, malign klonal miyeloid kök hücrelerin kontrolsüz çoğalmasına yol açar. Miyeloid sarkomlar ve lösemi kutisi gibi ekstramedüller belirtiler ortaya çıkabilse de, temel sorun hematolojik hücre üretimindeki bozulmalardır. Yaşlı hastalarda tam remisyon oranı yüksek olmasına rağmen, önemli sayıda hasta üç yıl içinde nüks yaşamaktadır. Bu sorunun üstesinden gelmek için yeni hedeflerin belirlenmesi gerekmektedir. Önceki çalışmamızda, AML hastalarında PSMB8’in yüksek ekspresyon seviyeleri göstermesi ve düşük ekspresyon seviyelerine sahip hastalara kıyasla daha düşük sağkalım oranları ile ilişkilendirilmesi dikkatimizi çekmiştir. Daha önceki çalışmamızda, PSMB8 hedef alınarak sanal ilaç taramaları, ADMET analizi ve ardından Moleküler Dinamik (MD) simülasyonları gerçekleştirilmiştir. Bu çalışmalar sonucunda AML tedavisi için üç potansiyel ilaç adayı belirlenmiştir: Adozelesin, Fiduxosin ve Omipalisib. PI3K/mTOR inhibitörü olarak bilinen Omipalisib, AML gelişiminde PI3K/mTOR yolak proteinlerinin aşırı ekspresyon göstermesi nedeniyle sitotoksisite analizi için dikkatimizi çekmiştir. Sonraki aşamada, HL60 hücre hattında Omipalisib’in sitotoksisitesi, PSMB8 inhibitörü olan ONX-0914 ile karşılaştırılmıştır. Bu araştırma, PSMB8'in Akut Myeloid Lösemi için olası bir hedef olabileceğini ve potansiyel bir ilacın hedefli tedavi için kullanılabileceğini gösterdi
Exploring Hydrological Response To Land Use/Land Cover Change Using the SWAT Plus Model in the İznik Lake Watershed, Türkiye
No full textLand use/land cover (LULC) changes significantly affect hydrological processes in watersheds. In this study, the Soil and Water Assessment Tool (SWAT+) model was employed to investigate the hydrological response to LULC changes in the ; Idot;znik Lake Watershed, a region of significant environmental and social importance in the Marmara Region of T ; uuml;rkiye. This study provides a novel understanding of water balance dynamics of the ; Idot;znik Lake Watershed through hydrological modeling. The SWAT+ model was calibrated and validated against observed monthly flow data from two gauging stations using three objective functions: Nash-Sutcliffe efficiency (NSE), Kling-Gupta efficiency (KGE), and the percent bias (PBIAS). The model was utilized to evaluate the impacts of LULC change on water balance components such as surface runoff, percolation, lateral flow, water yield, and evapotranspiration. The results revealed that the expansion of urban areas and reduction in forest land have led to an increase in surface runoff and a decrease in lateral flow and percolation, which in turn have impacted the overall water yield of the watershed. The findings of this study can inform land use planning and management decisions to mitigate the negative impacts of LULC changes on water resources in the ; Idot;znik Lake Watershed and similar regions
Investigating the Effects of Magnitude-Space Based Numerical Working Memory Loads on the Snarc Effect Under Different Number Judgment Tasks
No full textTepki Kodlarına İlişkin Uzamsal-Sayısal Bağıntı (SNARC) etkisi, küçük sayıların daha hızlı sol tepki uzamı, büyük sayıların ise daha hızlı sağ tepki uzamıyla ilişkilendirilmesi olgusunu ifade eder. SNARC etkisi üzerine yapılan önceki çalışma belleği (ÇB) araştırmaları, görsel-uzamsal ve fonolojik görevler kullanarak bilişsel yükü incelemiş ve bu etkinin esnekliğini vurgulamıştır. Bu tezde, zihinsel sayı dizisi (the Mental Number Line, MNL) uyumluluğu (küçük-sol/büyük-sağ ve küçük-sağ/büyük-sol) ile büyüklük-uzam temelli bilişsel yüklerin (uzam, büyüklük ve büyüklük-uzam) sayı değerlendirme görevleri üzerindeki etkileri araştırılmıştır. Katılımcılar, üç tür ÇB yükü içeren sayısal 1-geri görevini, MNL uyumlu veya uyumsuz formatlarda tamamlamışlardır. Hedeflere tepkiler, bir sayının önceki sayının uzamsal konumuna (uzam yükü), büyüklük kategorisine (büyüklük yükü) veya her ikisine birden (büyüklük-uzam yükü) uyup uymamasına göre verilmiştir. Her bir 1-geri değerlendirmesinden sonra, katılımcılar her bir sayı için ya tek-çift sınıflandırması ya da büyüklük değerlendirmesi (5'ten küçük/büyük) yapmışlardır. Bulgular, MNL uyumlu yüklerin tipik bir SNARC etkisine, uyumsuz yüklerin ise ters SNARC etkisine yol açtığını göstermiştir. Bu etki, uzam yükü altında, büyüklük yüküne kıyasla daha belirgin olmuştur. Tek-çift görevinde, uyumlu yükler tipik bir SNARC etkisi oluşturmuş, ancak uyumsuz yükler altında güçlü bir ters SNARC etkisi ortaya çıkmamıştır. Buna karşılık, büyüklük değerlendirme görevinde, uyumsuz yükler sunulduğunda daha belirgin bir ters SNARC etkisi gözlenmiştir. Bu bulgular, SNARC etkisini tamamen otomatik bir süreç olduğu anlayışını sorgulamakta ve sayılara ilişkin uzun-süreli temsiller ile ÇB etkilerinin bir arada var olabileceğini öne sürmektedir. Ayrıca, bu sonuçlar, sayı-uzam ilişkilerinin görev taleplerine ve bilişsel stratejilere göre dinamik olarak şekillendirilebileceğini vurgulamaktadır.The Spatial-Numerical Association of Response Codes (SNARC) effect refers to the phenomenon where smaller numbers are associated with faster left-side responses and larger numbers with faster right-side responses. Previous working memory (WM) research on the SNARC effect has examined cognitive load using visuo-spatial and phonological tasks, highlighting the effect's flexibility. This dissertation investigated the effects of mental number line (MNL) compatibility (small-left/large-right vs. small-right/large-left) and magnitude-space-based cognitive loads (space, magnitude, and magnitude-space) on number judgments. Participants completed a numerical 1-back task involving three types of WM loads presented in either MNL compatible or incompatible formats. Responses to targets were made based on whether a number matched the spatial position (space load), magnitude category (magnitude load), or both (magnitude-space load) of the preceding number. After each 1-back evaluation, participants performed either a single parity judgment (odd/even) or magnitude comparison (smaller/larger than 5). The results showed that MNL compatible conditions produced a regular SNARC effect, while incompatible conditions led to a reverse SNARC. The effect was more pronounced under the space load than under the magnitude load. In parity judgment, compatible loads produced a regular SNARC effect, whereas incompatible loads showed no reverse SNARC. In contrast, the magnitude comparison task revealed a more pronounced reverse SNARC under incompatible loads. These results challenge the SNARC effect as purely automatic, emphasizing the coactivation of long-term numerical representations and WM in shaping spatial-numerical associations. Furthermore, the findings highlight the effect's sensitivity to task-specific demands, demonstrating that spatial-numerical associations can dynamically adapt to varying cognitive strategies
2d Model of a Biomass Single Particle Pyrolysis-Analysis of the Influence of Fiber Orientation on the Thermal Decomposition Process
No full textUnderstanding the influence of heat transfer on the pyrolysis process is crucial for optimizing industrial biofuel production processes. While numerous scientific studies focus on experimental investigations of pyrolysis using laboratory-scale devices, many neglect the essential role of thermal energy in initiating and controlling thermal decomposition processes. This study presents a transient two-dimensional numerical model of biomass single-particle pyrolysis, which includes the energy balance, mass conservation equations and pyrolysis gas pressure and velocity equations. The model employs explicit numerical methods to manage the high computational demands of 2D transient simulations, but is successfully validated with the use of experimental data found in the literature. The model reflects the heterogeneous structure of wood by using different thermal conductivity coefficients depending on the wooden fibers' orientation. The results demonstrate the impact of fiber orientation on the heat transfer and thermal decomposition processes. The anisotropic properties of wood led to varied temperature fields and pyrolysis decomposition stages, aligning well with experimental data, thus validating the model's accuracy. The proposed approach can provide a better understanding and lead to improvement in biofuel production processes, enabling more efficient and controlled conversion of biomass into fuel. By optimizing the pyrolysis process, it contributes to the development of sustainable energy preservation and regeneration methods, supporting a shift towards more sustainable fuel production patterns using renewable biomass resources like wood
Incidence and Predictors of Clinical Outcomes in Real-Life Patients With Atrial Fibrillation Treated With Oral Factor Xa Inhibitors: the Follow-Up Results of the Anatolia-Af Study
No full textMurat, Selda/0000-0002-3935-0222ObjectiveThe main objective of this study is to determine the incidence and predictors of clinical outcomes in patients with AF treated with factor Xa inhibitors in a real-world setting.MethodsThe present study was a multicentre and observational study that included patients with AF who were treated with factor Xa inhibitors. The primary outcome was the composite of ischemic stroke, TIA, systemic embolism, major bleeding, and all-cause mortality.ResultsA total of 1162 patients from 26 cardiology centers were included in this study, with a median age of 72 years. During the median 12-month follow-up period, the primary outcome occurred in 195 patients (16.8%). Treatment with rivaroxaban compared with apixaban and edoxaban showed a lower rate of ischemic stroke, TIA, and/or systemic embolism (2.2% vs. 4.7% vs. 6.5%, respectively, p = 0.014). The major bleeding rate was similar between all three factor Xa inhibitors. The all-cause mortality rate in the rivaroxaban group was lower compared with the apixaban and edoxaban groups (9.8% vs. 15.1% vs. 12.4%, respectively, p = 0.042). Overall, the frequency of primary outcome was 13.8%, 19.6%, and 20.6% for patients treated with rivaroxaban, apixaban, and edoxaban, respectively (p = 0.019). Older age, male sex, low body weight, high bleeding risk, heart failure, hypertension, liver failure, and treatment with apixaban 2.5 mg b.i.d. were independently associated with the development of primary outcome.ConclusionThe follow-up data from the ANATOLIA-AF study provides detailed data about the incidence and independent predictors of adverse clinical outcomes in patients with AF treated with factor Xa inhibitor treatment
Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: Recql4/Fam13c Genes Address Common Hub Genes and Drugs
No full textObjective: The prevalence of breast cancer and gynaecological cancers is high, and these cancer types can occur consecutively as secondary cancers. The aim of our study is to determine the genes commonly expressed in these cancers and to identify the common hub genes and drug components. Materials and Methods: Gene intensity values of breast cancer, gynaecological cancers such as cervical, ovarian and endometrial cancers were used from the Gene Expression Omnibus database Affymetrix Human Genome U133 Plus 2.0 Array project. Using the linear modelling method included in the R LIMMA package, genes that differ between healthy individuals and cancer patients were identified. Hub genes were determined using cytoHubba in Cytoscape program. "ShinyGo 0.80" tool was used to determine the disease-specific biological KEGG pathways. Drug.MATADOR from the ShinyGo 0.80 tool was used to predict drug-target relationships. Results: The RecQ Like Helicase 4 and Family with Sequence Similarity 13 Member C genes were found to be similarly expressed in breast cancer and gynaecological cancers. Upon KEGG pathway analyses with hub genes, Drug.MATADOR analysis with hub genes related to cancer related pathways was performed. We have determined these gene/drug interactions: NBN (targeted by Hydroxyurea), EP300 (targeted by Acetylcarnitine) and MAPK14 Conclusion: The drugs associated with hub genes determined in our study are not routinely used in cancer treatment. Our study offers the opportunity to identify the target genes of drugs used in breast and gynaecological cancers with the drug repurposing approach
Breaking the Silence: White Privilege Intervention in the Netherlands
No full textIn the Netherlands, Diversity, Equity, and Inclusion (DEI) efforts typically avoid using the term "race", instead adopting a broader "diversity inclusion" framework that shifts focus from racial inequalities to cultural differences. Our project aimed to introduce, test, and apply a framework to reduce color-evasive racial attitudes while fostering empathy among White participants toward racialized individuals. We tested a video intervention designed to reduce color-evasive attitudes and explored whether a self-compassion-based writing exercise could enhance ethnocultural empathy-encompassing awareness, beliefs, and actions toward racialized individuals. Specifically, we examined whether this intervention reduced White fear (anxiety about interacting with racialized individuals) and increased guilt and affective empathy when learning about racism. In an online, within-between-subjects experiment, 301 White Dutch participants completed a writing task. In the experimental condition (n = 151), participants reflected on a marginalized identity and practiced self-compassion; in the control condition (n = 150), they wrote on a neutral topic. All participants then watched a video of racialized individuals discussing the harms of color-evasive attitudes. A paired-sample t-test showed the video intervention reduced color-evasive racial attitudes in all participants. However, general linear model analyses found no direct or indirect effect of the writing intervention on ethnocultural empathy. These findings informed a White privilege awareness and allyship workshop (see Supporting Information).We sincerely thank all participants in this study for their invaluable contributions. We also wish to thank the Department of Behavioural and Movement Sciences at the Vrije Universiteit Amsterdam for providing Nivedita Singhal with funding for her research master's dissertation, which made this work possible. We are equally grateful to the Association for Psychological Science (APS) for awarding us the Small Grants for Teaching Projects and to the Student Well-Being Team at Vrije Universiteit Amsterdam. Their support is instrumental in funding and implementing the White Privilege and Allyship Workshops, developed based on the findings of this research.APS Fund for Teaching and Public Understanding of Psychological Science; Department of Behavioural and Movement Sciences at the Vrije Universiteit Amsterda
A Design-Oriented Framework on Theory Development Around Emerging Phenomena
No full textDesign is increasingly encountering new questions and topics that offer exciting research opportunities, yet developing theories around emerging phenomena is challenging. These phenomena are nonlinear, ambiguous, multi-layered, and exhibit recursive adaptation. I begin by describing why and how theory development for emerging phenomena might differ from traditional approaches. I then propose an initial framework for emergence in design research focusing on four issues: positioning, structure, communication, and evaluation, and alternating between discovery and creation views. First, the framework lays the groundwork for theorising about emerging phenomena, primarily highlighting the use and integration of new technologies that alter existing paradigms. Second, it emphasises the different characteristics of building theories for emerging phenomena, presenting it as a novel pathway compared to the 'safe' territory of traditional design research approaches. A design research use case that integrates Explainable AI (XAI) into healthcare decision-making exemplifies these characteristics. Third, to evaluate such theorising, I introduce the notion of 'adaptive rigour,' which ensures that the evaluation process remains robust and credible while being flexible enough to accommodate the evolving nature of emerging phenomena. Overall, I argue that considering the concepts in the framework can open up new possibilities and help expand our discipline's knowledge development efforts
From Tactical To Strategic Sustainability Communication: a Qualitative Study on Corporations in Türkiye
No full textPurposeThis study aims to examine the extent to which companies internalize, adopt and communicate the issue of sustainability. With this aim, research questions address companies' approaches to sustainable development goals (SDGs), the extent to which the concept of sustainability is reflected in the goals, vision, mission and values of the organizations and the interrelationship between corporate identities, SDGs, sustainability projects and communication activities of the companies.Design/methodology/approachContent analysis is employed on the sustainability reports, websites, social media accounts, media releases and news of the corporations listed in BIST Sustainability Index (2020) in T ; uuml;rkiye. The typology of sustainability communication processes (Newig et al., 2013) is utilized for data analysis to reveal an overall picture of the companies' approach to sustainability communication.FindingsResearch findings demonstrated that only 11 companies internalize, adopt and communicate the issue of sustainability. A total of 32 companies make no mention of sustainability in their vision, mission, purpose or values. It is observed that few companies establish their entire communication on sustainability strategy. Although some of the companies' purpose of existence is sustainability, and they manage valuable projects, their approach to communication is still tactical. The study reveals that most of the companies take a tactical approach to sustainability and fewer adopt strategic actions and communications.Originality/valueIn T ; uuml;rkiye, research on sustainability involves either optimistic evaluations of governmental organizations or limited case studies on specific SDGs, particular sectors or social media analyses. This research exposes the holistic picture of sustainability and communication among the companies listed in the BIST Sustainability Index. The results of the holistic approach suggest that organizations should improve their communication about sustainability and communication for sustainability to activate their publics