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Ecological EF in alcohol-dependent patients
Get PDFObjective: To investigate the characteristics of ecological executive functioning in alcohol- dependent patients. Methods: The Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) was used to assess 103 alcohol-dependent patients and 106 healthy volunteers. Results: The total score and all factor scores of the alcohol-dependent patients were significantly higher than those of the healthy volunteers (all P<0.01). The daily alcohol consumption of alcohol-dependent patients was significantly positively correlated with working memory and emotional control of executive functioning (both P<0.05). Emotional control of executive functioning was identified as a risk factor for alcohol dependence (OR=1.375,P<0.05). Conclusion: Alcohol-dependent patients exhibited significant impairment in ecological executive functioning, with greater impairment observed in those with higher alcohol consumption. Poor emotional control was identified as a risk factor for alcohol dependence
The application of methylation-sensitive amplified polymorphism (MSAP)in ecology
Get PDFDNA methylation is one of the most important epigenetic modifications in living organisms and its application in ecology is becoming increasingly widespread. Based on the collection and review of relevant literature in ecological epigenetics, this paper introduces the principles, advantages, and limitations of Methylation-Sensitive Amplified Polymorphism (MSAP) technology, as well as its applications and prospects in ecology. MSAP has become a powerful tool for studying DNA methylation levels due to its wide application and ease of operation. It is particularly useful in exploring how organisms rapidly adapt to habitat changes and how invasive species overcome genetic bottlenecks. MSAP technology can effectively reveal epigenetic differences within or between biological populations, serving as a valuable complement to the study of genetic diversity and genetic variation
Standardizing Clinical NGS Applications—Based on ACMG Standards
Get PDFNext-generation sequencing (NGS)technology has been applied in clinical laboratories. The development of this technology, along with the expansion of testing scale and scope, has significantly reduced the cost of genetic testing. The clinical applications of NGS are continuously expanding, including targeted gene panel testing, individual exome, or whole-genome analysis. Moreover, NGS technology has further improved treatment decision-making and prediction for high-risk populations of certain diseases. However, the development of NGS also poses challenges, including the confusion of choices brought by sequencing platforms and technological updates, and the inconsistency of clinical validation of sequencing results. To help clinical laboratories better understand NGS technology, resolve issues related to clinical validation, and correctly select NGS sequencing platforms and methods, as well as to continuously monitor NGS and ensure high-quality sequencing results and their clinical interpretation, this article summarizes and discusses the professional standards and guidelines of the American College of Medical Genetics and Genomics (ACMG)regarding the clinical application of NGS technology. This is intended for reference by molecular diagnostic professionals in China when formulating domestic industry standards
Study on Biology and Ecology of Rare Tree Acer miaotaiense
Get PDFAcer miaotaiense is a third-grade nationally protected plant in China. It was originally recorded as sporadically distributed in a few areas of the western section of the Qin ling Mountains. In recent years, a wild population of Acer miaotaiense was discovered for the first time in the Fu Niu Mountains of Henan Province. This discovery has refined and corrected the delineation of the distribution range of this species in China over the past half-century, and it is of great significance for research on its origin, resource protection, and cultivation techniques. The morphological characteristics and biological traits of Acer miaotaiense were observed and described, and its wild populations were investigated. The results show that the species has stringent habitat requirements. Although it is one of the dominant species in the surveyed community, its age structure is extremely incomplete, and the population shows a trend of gradual decline. This paper also explores the reasons for the endangerment of Acer miaotaiense and proposes conservation strategies
The effect of rAd-p53+cisplatin on gastric cancer cell growth and KAI1/CD82 expression
Get PDFObjective To investigate the effects of rAd-p53 and cisplatin (DDP)alone or in combination on the proliferation, apoptosis, and KAI1/CD82 protein expression of human gastric cancer SGC7901 cells. Methods SGC7901 cells were treated with rAd-p53, DDP, or their combination for 24,48, and 72 hours. The proliferation activity of SGC7901 cells was measured using the CCK-8 assay. Apoptosis rates were determined by flow cytometry, and the expression of KAI1/CD82 protein was detected by immunohistochemistry. Results Both rAd-p53 and DDP alone, as well as their combination, inhibited the proliferation of SGC7901 cells in a dose-and time-dependent manner. The proliferation inhibition rate of the combination group was significantly higher than that of the single-agent groups, with statistically significant differences compared to the negative control group(P<0.05).After 48 hours of treatment with rAd-p53,DDP,or their combination, the apoptosis rates were 36.94%±0.78%,28.79%±2.37%,and 69.26%±0.63%,respectively,all of which were significantly higher than that of the negative control group(16.72%±1.54%,P<0.05).Both rAd-p53 and DDP alone, as well as their combination, upregulated the expression of KAI1/CD82 protein, with the combination group showing the most significant increase. Conclusion Both rAd-p53 and DDP alone, as well as their combination, can inhibit the growth of gastric cancer SGC7901 cells and induce apoptosis. The combination of the two drugs enhances the inhibitory effect on gastric cancer cells. rAd-p53 may induce apoptosis in SGC7901 cells by upregulating the expression of KAI1/CD82, thereby enhancing the antitumor effect of DDP
The diagnostic value of combined TCD and CTA in intracranial arterial stenosis
Get PDFTo investigate the clinical diagnostic value of computed tomographic angiography (CTA)and transcranial Doppler (TCD)used separately and in combination for intracranial arterial stenosis. Methods: A total of 47 patients diagnosed with acute ischemic stroke at the Second Affiliated Hospital of Qiqihar Medical University from June 2015 to June 2016 were selected as the study subjects. All patients underwent both TCD and CTA examinations, followed by digital subtraction angiography (DSA). Results: Using DSA as the gold standard, the results of TCD and CTA were evaluated. Among the 47 patients, a total of 67 intracranial arterial stenoses were detected by DSA.TCD identified 53 stenoses, CTA identified 52 stenoses, and the combined diagnosis of CTA and TCD identified 64 stenoses. The combined diagnosis of CTA and TCD was significantly higher than that of a single examination method.().Conclusion: The combined diagnosis of intracranial arterial stenosis using TCD and CTA can avoid missed diagnoses and provides a reliable basis for clinical decision-making, offering an objective foundation for further clinical treatment
Application of silk fibroin in biomedical engineering
Get PDFSilk fibroin is the main component of silk and is known for its excellent biocompatibility, degradability, mechanical properties, and safety. It is non-toxic, and its raw materials are readily available, making it a popular material in the preparation and research of biomedical materials. This article reviews the healthcare benefits of silk fibroin, such as its role in lowering blood sugar and inhibiting bacterial growth, as well as its applications and development prospects in biomedical engineering fields, including drug release, hemostasis, wound healing, tissue engineering scaffolds, and other biomedical materials
Zeolite powder in Epdm rubber: Sound absorption effects
Get PDFIn order to enhance the sound absorption performance of ethylene-propylene-diene monomer (EPDM) rubber and develop a lightweight, cost-effective composite material with good sound absorption properties, especially in the low-frequency range, EPDM rubber was used as the matrix and zeolite powder (MS)as the filler. Porous sound-absorbing composite materials were prepared through mixing in a mixer and hot pressing in a vulcanizing machine, and their sound absorption properties were tested. By varying the content of MS, the thickness of the composite material, and the distance of the rear cavity, the sound absorption performance of the EPDM/MS porous sound-absorbing material was tested using an SW230 impedance tube. The experimental results showed that the sound absorption performance of the composite material improved with the increase of MS content. When the MS content was 20%and the sample thickness was 4 mm, the sound absorption coefficient of the composite material at 2500 Hz reached 0.65. When a certain thickness of cavity was placed behind the composite material, the sound absorption peak occurred only within specific frequency ranges. The experimental results indicate that the EPDM/MS porous sound-absorbing material has good sound absorption properties
A study on the ecological water requirement in the Xin\u27 an county section of the Jian river channel
Get PDFTaking the urban section of Xin\u27 an County in the Jian River as an example, this study statistically analyzed hydrological data from the Xin\u27 an Hydrological Station from 1959 to 2010.It used the Tennant method from hydrology and the R2CROSs method from hydraulics to analyze and calculate the basic ecological water requirement within the river channel. Additionally, the study calculated the water requirements for river water purification, river evaporation and seepage, and the minimum sediment transport in the river channel. Following the principle of non-redundant calculation, the maximum value among these water requirements was taken, resulting in an ecological water requirement of 3010.0 m³/s for the urban section of the Jian River. This water volume is the optimal requirement for restoring the ecological structure and functional health of the river section. This result has important reference significance for the sustainable use of water resources in the river channel and the maintenance of the river ecosystem balance
Research progress on Nano-Tungsten oxide gas sensors
Get PDFIn the field of research on the detection of various harmful gases, nano-semiconductor metal oxide gas sensors hold a very important position. As an n-type semiconductor metal oxide, tungsten oxide has become a research focus and hotspot in gas-sensitive materials in recent years due to its unique structural and performance characteristics. This paper briefly introduces the gas-sensing response mechanism of tungsten oxide-based gas-sensitive materials, summarizes the main processes and directions for improving the gas-sensing performance of nano-tungsten oxide materials in recent years, and finally points out its own shortcomings and future research and development directions