Bezmialem Vakıf Üniversitesi Kurumsal Akademik Arşiv
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Assessment of metabolic risk factors for nephrolithiasis in patients with autosomal dominant polycystic kidney disease: a cross-sectional study.
No full textMenstrüel Siklusun Farklı Evrelerinde Yüksek Frekans Odyometri Değerlendirmesi
No full textGiriş-Amaç: Menstrüel döngü; foliküler evre, ovulasyon evresi ve luteal evre olmak üzere üç evreye ayrılır. Menstrüel döngü sırasındaki östrojen ve progesteron gibi hormonların salgı seviyeleri değişiklikler iç kulak homeostazını ve işitsel duyusal işlemeyi etkiler. Östrojen artışı, sinir sisteminde aktif rol oynayan inhibitör nörotransmitter GABA’nın salgılanmasını uyararak inhibitör etkilerini arttırabilir. Tersine, progesteron artışı nöronların duyarlılığını azaltabilir ve östrojenle GABA salınımını azaltabilir. Hormonlardaki bu değişikliklerin işitsel, koku alma ve tat alma duyularını etkileyebileceğini bildiren çalışmalar mevcuttur. Bu çalışmanın amacı, menstrüel siklus evrelerinde hormonal değişikliklerin işitsel işlev üzerindeki potansiyel değişiklerin etkisinin ortaya konulması ve hormonal değişiklerin koklea ile bağlantısını odyolojik test bataryalarıyla değerlendirmektir. Gereç-Yöntem: Bu çalışmaya, dahil edilme kriterlerini karşılayan, düzenli menstrüel döngüye ve normal işitmeye sahip, 18-35 yaş arası, 20 sağlıklı kadın birey dahil edilmiştir. Katılımcılara menstrüel siklusun foliküler (1-5.gün; faz1), ovulasyon (14-17.gün; faz2) ve luteal (21-28.gün; faz3) evreleri sırasında yüksek frekans odyometri değerlendirmesi yapılmıştır. Bulgular: Bu çalışma sonucunda sağ kulak işitme eşiği 11.2 kHz\"de luteal fazda [(-0,75) ± 5,91] foliküler [2 ± 5,47] ve ovulasyon [2 ± 6,76] fazlarına göre anlamlı ölçüde daha iyi elde edilirken, 10 kHz\"de sol kulak işitme eşiği luteal [(-3,5) ± 5,15] fazda foliküler faza [(-0,5) ± 5,82] göre anlamlı ölçüde daha iyi elde edilmiştir. Tartışma-Sonuç: Hormonal dalgalanmalar metabolizma, ses parametreleri, bazal metabolik sıcaklık, kalp atış hızı ve işitme dahil olmak üzere birçok fizyolojik süreçteki değişikliklerle ilişkilidir. Bu bilgiden yola çıkarak hormonların işitsel sistem üzerindeki etkileri araştırılmaya devam etmektedir. Ancak yapılan çalışmalarda daha çok işitsel potansiyeller ve merkezi işitsel yolağa odaklanılması sebebiyle hormonal değişikliklerin periferik işitsel sisteme etkisi için kesin bir sonuca henüz varılamamıştır. Östrojen ve progesteron hormonları için koklear reseptörlerin varlığı nedeniyle menstrüel siklusun farklı evrelerinde bu hormonların konsantrasyonlarındaki değişiklikler iç kulak homeostazını ve işitsel fonksiyonları etkileyebilmektedir. Bu çalışmanın literatürdeki bu eksikliğe dikkat çektiği düşünülmekle birlikte ileride yapılacak çalışmalarla fizyolojisinin daha iyi anlaşılacağı düşünülmektedir. Yapılan çalışma sonucunda menstrüel siklusda yüksek frekans işitme eşiklerinde klinik olarak anlamlı farklılıklar gözlenmemiştir. Bu konuda daha fazla katılımcı ile daha fazla çalışmaya ihtiyaç vardır
Pain Increases The Risk For Sarcopenia In Community-Dwelling Adults: Results From The English Longitudinal Study Of Ageing.
No full textEvaluation of miR-526b-3p, miR-1179, miR-3529-3p, miR-5011-5p as potential diagnostic biomarkers in isolated cervical dystonia
No full textVerbascum sinuatum extract induces cell death in K7M2 osteosarcoma cells by its immunomodulatory effect on LPS-stimulated RAW 264.7 cells
No full textA Rare Complication of Umbilical Vein Catheterization: TPNoma: US, X-ray, and MRI Findings
No full textBACKGROUND: Umbilical vein catheterization (UVC) is an early venous access route in newborns and is frequently used for delivering total parenteral nutrition (TPN) and medications. Vascular, hepatic parenchymal, and infectious complications of UVC can be seen rarely. OBJECTIVE: We present preterm neonates\" X-ray, US, and MRI findings with parenchymal TPN extravasation and portal vein thrombosis. Our case was the first case about MRI findings of TPNoma. CASE PRESENTATION: A 30 week female with a birth weight of 1340 g was born via Cesarean section. Due to the diagnosis of transient tachypnea of the newborn and prematurity, the infant was hospitalized in the neonatal intensive care unit. On the first day of hospitalization, UVC was inserted and TPN with 20% lipid content was started. After 10 days, UVC was removed and TPN treatment was continued with a piccline catheter. Abdominal US and portal venous Doppler examination was applied to the patient whose general condition deteriorated on the 12th day. US and Doppler revealed a lesion of 17x17x18mm in size with lobulated contour, hyperechoic heterogeneous internal structure, and no central or peripheral blood supply was observed in the left lobe of the liver. Moreover, a filling defect compatible with a thrombus was observed in the proximal part of the left portal vein. An abdominal MRI was performed to characterize this liver lesion. Axial T1 weighted and T2- weighted images showed a heterogeneous hyperintense lesion without contrast enhancement. Axial fat saturation T1-weighted and out of phase T1-weighted images showed a reduction in signal intensity. US and MRI examinations showed that the thrombosed umbilical vein ended superior to the lesion. In the differential diagnoses, fat-containing lesions such as lipoma-teratoma and fat-containing collection secondary to extravasation of TPN treatment via UVC were thought. CONCLUSION: In the differential diagnosis of liver localized lesions in newborns, UVC-related liver injury should be considered and the localization of the catheter tip should be checked. In case of the doubt based on US and X-ray findings, presence of fat on MRI could be diagnosed. Serious complications should be avoided with catheter revision or removal
Effect of hippotherapy on balance, functional mobility, and functional independence in children with Down syndrome: randomized controlled trial
No full textImpaired muscle strength, proprioceptive and vestibular deficits, and orthopedic dysfunction are common disorders associated with Down syndrome (DS). Hippotherapy uses the horses’ multidimensional movement to improve posture, balance, and overall function, both motor and sensory. Research evidence supports hippotherapy as an effective, medically recognized intervention for the rehabilitation of gross motor skills. The aim of this study was to determine the effect of hippotherapy on balance, functional mobility, and functional independence in children with DS. Thirty-four children with DS were randomly assigned to the experimental (hippotherapy) and control groups after the initial assessment. Both groups received physiotherapy including balance exercises, and the experimental group also received hippotherapy as an integrative therapy. Pediatric Balance Scale (PBS), Timed Up and Go Test (TUG), and Functional Independence Measure for Children (WeeFIM) were used before and after the intervention. Baseline outcome measures (PBS, TUG, WeeFIM) were statistically similar between groups (p > 0.05). After the intervention, PBS and TUG scores improved in both groups (p < 0.05). On the other hand, WeeFIM scores improved just in the hippotherapy group (p < 0.05). Conclusion: Therefore, providing hippotherapy as an integrative therapy to physiotherapy will be more effective in improving the functional independence of children with DS. Trial registration: NCT05297149 (March 2022, retrospectively registered).What is Known:• Hippotherapy has an improvement effect on balance and functional independence in different diseases and age groups, but the evidence is limited in DS.• There is limited evidence about the effect of hippotherapy on functional mobility in different diseases and age groups, but there is no evidence in DS.What is New:• Hippotherapy is a safe and effective approach to support improvement in functional independence in children with DS
Comment on “Association between hemoglobin level and cognitive profile in old adults: A cross-sectional survey”
No full textAkademik kütüphaneler Sürdürülebilir Kalkınma Amaçlarının geliştirilmesine nasıl katkıda bulunabilir: Türkiye durum analizi
No full textSpeech auditory brainstem response in audiological practice: a systematic review
No full textBackground: Speech-ABR is an auditory brainstem response that evaluates the integrity of the temporal and spectral coding of speech in the upper levels of the brainstem. It reflects the acoustic properties of the stimulus used and consists of seven major waves. Waves V and A represent the onset of the response; wave C transition region; D, E, and F waves periodic region (frequency following response); and wave O reflects the offset of the response.PurposeThe aim of this study is to evaluate the clinical availability of the speech-ABR procedure through a literature review.MethodsLiterature search was conducted in Pubmed, Google Scholar, Scopus and Science Direct databases. Clinical studies of the last 15 years have been included in this review and 60 articles have been reviewed.ResultsAs a result of the articles reviewed, it was seen that most of the studies on speech ABR were conducted with children and young people and generally focused on latency analysis measurements. Most used stimulus is the /da/ syllable.ConclusionsSpeech ABR can objectively measure the auditory cues important for speech recognition and has many clini- cal applications. It can be used as a biomarker for auditory processing disorders, learning disorders, dyslexia, otitis media, hearing loss, language disorders and phonological disorders. S-ABR is an effective procedure that can be used in speech and language evaluations in people with hearing aids or cochlear implant. It may also be of benefit to the aging auditory system\"s ability to encode temporal cues