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In Vivo Efficacy of Momordic Charantia Leaves Extract against Rats Infected with Trypanosome Brucei Brucei (Federe Strain
No full textIn vivo study was conducted using thirty adult male rats which were randomly divided into six groups of five rats each. Groups A, B, C, D and E were infected with 1 × 106 of Trypanosomes; Group F was neither treated nor infected. Methanolic leaf extract of Momordica charantia was administered intraperitoneally to rats in groups B, C, D, and E at doses of 100, 200, 500 and 1000 mg/kg body weight, respectively. The groups treated with the extract showed a significant (p0.05) different. Whereas groups B and C were significantly different (p<0.05) and group A was highly significant (p<0.01)
Assay Method Development and Validation for Simultaneous Estimation of Mometasone Furoate and Azelastine HCL for Nasal Spray by RP-HPLC
No full textA simple, precise, accurate, method was developed and validated for analysis of Mometasone Furoate and Azelastine Hydrochloride in nasal spray formulations. For development, different chromatographic condition and stress conditions like acid, base, peroxide, thermal and humidity as per ICH guidelines were used. Method was developed on reversed-phase C18 column using a mobile phase consisting of potassium dihydrogen, phosphate buffer and acetonitrile. Other HPLC parameters were flow rare 1 ml/min, detection wavelength 239 nm, injection volume 20 µl and column temperature 30°C. The developed method was further validated with respect to linearity, precision, accuracy, specificity and robustness. The results obtained were within the acceptance criteria as per ICH guidelines
Assess the Level of Stress and Coping Strategies in Academic Performance among B.Sc. Nursing 1st Year Students
No full textIntroduction: Stress is a reality of nature-forces from the internal or outside world affecting the individuals. The individual responds to strain in methods that affect the man or woman in addition to their environment. Every person has pressure and we are facing it in our day by day lifestyles. Pressure is the subjective feeling produced with the aid of activities that are uncontrollable or threatening. The nursing college students also face social, emotional, and physical and circle of relatives’ trouble which might also affect their gaining knowledge of capacity and educational overall performance. Method: A research design used for this study was descriptive design which belongs to non-experimental research design. Convenient sampling technique was used to select the sample and the sample size was 50 B.Sc. Nursing 1st year nursing students of Jaipur nursing college Amer Jaipur. Data were collected by using structured knowledge questionnaire. Analysis was carried out by the use of descriptive and inferential statistics. Results: The Result showed that the mean stress score of the students was 61.92 (SD=12.395) and the mean coping score of the students was 58.64 (SD=12.893). Association was done between demographic variables and level of stress score of students by using chi-square (χ2) test that there was significant association between age, gender and family income and no significant association between religion, type of family and place of residence. Association with coping score of nursing student there was significant association between monthly family income and no significant association between age, gender, religion, type of family and place of resident
By the time she diagnosed with GM1 Gangliosidoses she is no more: Case Presentation
Full text linkBeta-galactosidase-1 deficiency is rare lysosomal storage disorder which is also called as GLB1 deficiency or Landing disease. It is an autosomal recessive disorder whose age of onset is usually child hood. Deficiency of beta – galatosidase enzyme due to mutations of GLB1 gene results in toxic accumulation of gangliosides in either body tissues or particularly in the central nervous system which ultimately ends up in neurovisceral, ophthalmological and dysmorphic features. The types of GM1 gangliosidosis is based on the age of onset; infantile form which is severe and rapidly progressive, a late infantile or juvenile form with onset usually from seventh month to 3 years of age accompanied with delayed motor and cognitive development and thirdly an adult or chronic form with late onset characterized by generalized dystonia. The severity of disease depends on the level of beta – galactosidase activity. Due to the wide spectrum of disease, the diagnosis may be difficult. Facial coarsening, hypertrophic gums, cherry -red macula, visceromegaly, dysostosis and psychomotor are some signs of storage disorders which may help to diagnose GM1 gangliosidosis. The confirmative diagnosis is biochemical assay of beta – galactosidase activity by molecular genetic testing. GLB1 molecular analysis can be done either by chorionic villus or amniotic cells as prenatal diagnosis. There is no specific treatment for GM1 gangliosidosis; treatment is symptomatic as well as supportive. Extremely poor prognosis found in severe infantile form.
A Descriptive Study to Assess the Level of Knowledge Regarding Weaning Among Primipara Mothers of Infants
Full text linkIntroduction: The birth of a child is a significant event in any family. Health of the growing child is always a matter of a great concern to the parents. Physical health is important because it is associated with mental and social development. Good nutrition is very important to promote physical health of the child in order to build up healthy life. Nutritional status of infant will be based on breast feeding and weaning practices. The objective of the study were To assess the level of knowledge regarding weaning among primipara mothers of infants and To associate the level of knowledge of primipara mothers of infants with their selected demographic variables. Materials and methods: Research approach was quantitative and research design was descriptive research design. 30 samples that fulfilled the inclusion criteria were selected by non-probability convenient sampling technique. The tool used for the data collection comprises of 2 sections: section A – demographic variables; section B – A structured questionnaire to assess the knowledge on weaning among primipara mothers of infants. Data collected were analyzed by using descriptive and inferential statistics. Results: the analysis reveals that 56.6% (17) mothers of infants have inadequate knowledge; 40% (12) have moderate knowledge; 3.3% (1) have adequate knowledge. There is a significant association found between the “educational status, occupation, type of family and no. of children” with knowledge. Conclusion: The study findings concludes that majority primipara mothers of infants 56.6% (17) have inadequate knowledge. The nurse administrator should plan to conduct health education programs in community to initiate healthy weaning practices
Overview of Hysteria; Introduction, Review, Causes, Signs And Symptoms, Complications And Management
No full textHysteria is a condition in which people assume to be ill. These people need care and counselling. The problem is not merely with mental aspect of person but also with psychological and social domains too. In one form it can be a simple way to evade danger; thus may be sometimes best defence mechanism
An Experimental Study to Evaluate the Effectiveness of Ergonomic Exercise on Ergonomic Health Symptoms among Computer Workers in Selected I.T Company, Coimbatore.
No full textBackground: Ergonomic Health Symptoms is Collective term for a range of condition including injury characterized by discomfort and persistent pain in muscle, tendon and soft tissues. Ergonomic Exercises is a group of exercise which includes palming, blinking, near-far focus, scanning, head rolling, hand, shoulder, hand and fingers, back stretch and upper back stretch exercises done at a person’s work stations to get relief from ergonomic health symptoms. Aim: To evaluate the effectiveness of the Ergonomic Exercise on Ergonomic Health Symptoms among Computer Workers in Selected I.T Company, Coimbatore. Methods: Quasi experimental pre-test post-test with control group design was adopted. Ergonomic health symptoms tool was used to assess the ergonomic health symptoms of computer workers. Purposive sampling technique was adopted to choose the participants. The samples were assigned into experimental group (30) and control group (30). Ergonomic exercise was taught to experimental group with the help of power point presentation. From the second day onwards the participants of experimental group were allowed to practice these exercise with researcher supervision and instruction under two sessions for a period of 30 days, where each session lasted for 15 minutes. After 30 days of this intervention, post test was conducted to evaluate the effectiveness of ergonomic exercise with the help of ergonomic health symptoms tool for both experimental and control group. Result: There was significant reduction in ergonomic health symptoms among experimental group computer workers after ergonomic exercise. Thus, ergonomic exercise can be implemented as an effective therapeutic intervention in reducing the ergonomic health symptoms of computer workers.
A Study to Evaluate the Effectiveness of Mass Awareness Program on Knowledge and Attitude Regarding Oral Cancer among Adults in Selected Community, Bangalore
No full textOral cancer may begin in tongue and floor of the mouth. It is the most common cancers seen in both Indian men and women as can be gauged from the records of the National Cancer Registry Programmer. India has one of the highest incidences of oral cancer. In the rural community most of the adults have the habit of using the tobacco either in any of the form including both men and women, it is the responsibility of the adults to know regarding tobacco use and its side effects. Since tobacco use for long time may cause oral cancer the adults have lack of knowledge and different attitudes towards tobacco use and oral cancer. An evaluative approach with one group pre-test post-test design in quasi experimental design was used to evaluate the effectiveness of Mass Awareness Program regarding oral cancer among adults. The study was conducted in Kumbalagudu, Bengaluru. Purposive sampling technique was used to select 60 samples. The tool used in the data collection was structured knowledge questionnaire and modified Likert’s attitude scale, which compromised 10 demographic items, 20 items on oral cancer, 15 attitude statements. The reliability of the tool was established by Split Half technique, with ‘r=.85’ for knowledge and “r=0.914” for attitude scale. The pre-test was administered to 60 adults followed by the Mass Awareness Program on the same day and after 7 days post-test was conducted to the same samples using the same tool. Data gathered was analyzed using descriptive and inferential statistics in terms of frequency, percentage, mean, standard deviation, paired‘t’ test, chi-square test and correlation coefficient. Hence the findings revealed that Mass Awareness program was effective in enhancement of knowledge and changing attitude regarding oral cancer among adults.
Informed Consent in Medical decision making in India
No full textConsent is one of the key elements for protection of welfare of patients or research participants. The physician has a legal and ethical responsibility to provide adequate information to the patient so that he or she is able to process the information and make appropriate decisions. The patient’s consent must be voluntary and competent. In order to meet the requirements for effective, informed decision making, a physician must disclose material facts, which are relevant to decision making, including the patient’s diagnosis, proposed treatment, risks and benefits of the treatment, alternative treatments along with their risks and benefits, and the risks of refusal. A physician must answer truthfully about the number of similar procedures or cases performed, and disclose success rates, and any financial conflict(s) of interest. The physician must advise patients of all personnel involved in their care and their respective roles, including residents, students, and equipment representatives.
Move Forward to Save a Life: A Review Article on Cardiopulmonary Resuscitation
No full textImagine walking on the road and suddenly seeing a passerby suffering from chest pain and collapsing. Would you be able to give a life-saving cardiopulmonary resuscitations CPR? The answer would be most likely; no people should continue to jump in quickly to give CPR, using breaths if they’ve been trained. In case of sudden cardiac arrest, the mortality is very high almost 90 percentage or more is not resuscitated within 10 minutes. A quick action, proper training, use of technology and coordinated efforts can increase survival from cardiac arrest. Survival depends on immediate CPR and other actions that starting with bystanders